Adhesion to nanofibers drives cell membrane remodeling through one-dimensional wetting

Arthur Charles-Orszag, Feng-Ching Tsai, Daria Bonazzi, Valeria Manriquez, Martin Sachse, Adeline Mallet, Audrey Salles, Keira Melican, Ralitza Staneva, Aurélie Bertin, Corinne Millien, Sylvie Goussard, Pierre Lafaye, Spencer Shorte, Matthieu Piel, Jacomine Krijnse-Locker, Françoise Brochard-Wyart, Patricia Bassereau and Guillaume Duménil ()
Additional contact information
Arthur Charles-Orszag: INSERM, Institut Pasteur
Feng-Ching Tsai: Institut Curie, PSL Research University, CNRS UMR168
Daria Bonazzi: INSERM, Institut Pasteur
Valeria Manriquez: INSERM, Institut Pasteur
Martin Sachse: Ultrapole, Institut Pasteur
Adeline Mallet: Ultrapole, Institut Pasteur
Audrey Salles: Imagopole, Institut Pasteur
Keira Melican: INSERM, Institut Pasteur
Ralitza Staneva: Institut Curie, PSL Research University, CNRS, UMR 144
Aurélie Bertin: Institut Curie, PSL Research University, CNRS UMR168
Corinne Millien: Paris Cardiovascular Research Center
Sylvie Goussard: INSERM, Institut Pasteur
Pierre Lafaye: Antibody Engineering, Institut Pasteur
Spencer Shorte: Imagopole, Institut Pasteur
Matthieu Piel: Institut Pierre-Gilles De Gennes
Jacomine Krijnse-Locker: Ultrapole, Institut Pasteur
Françoise Brochard-Wyart: Institut Curie, PSL Research University, CNRS UMR168
Patricia Bassereau: Institut Curie, PSL Research University, CNRS UMR168
Guillaume Duménil: INSERM, Institut Pasteur

Nature Communications, 2018, vol. 9, issue 1, 1-14

Abstract: Abstract The shape of cellular membranes is highly regulated by a set of conserved mechanisms that can be manipulated by bacterial pathogens to infect cells. Remodeling of the plasma membrane of endothelial cells by the bacterium Neisseria meningitidis is thought to be essential during the blood phase of meningococcal infection, but the underlying mechanisms are unclear. Here we show that plasma membrane remodeling occurs independently of F-actin, along meningococcal type IV pili fibers, by a physical mechanism that we term ‘one-dimensional’ membrane wetting. We provide a theoretical model that describes the physical basis of one-dimensional wetting and show that this mechanism occurs in model membranes interacting with nanofibers, and in human cells interacting with extracellular matrix meshworks. We propose one-dimensional wetting as a new general principle driving the interaction of cells with their environment at the nanoscale that is diverted by meningococci during infection.

Date: 2018
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DOI: 10.1038/s41467-018-06948-x

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