Cloaking nanoparticles with protein corona shield for targeted drug delivery

Jun Yong Oh, Han Sol Kim, L. Palanikumar, Eun Min Go, Batakrishna Jana, Soo Ah Park, Ho Young Kim, Kibeom Kim, Jeong Kon Seo, Sang Kyu Kwak, Chaekyu Kim (), Sebyung Kang () and Ja-Hyoung Ryu ()
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Jun Yong Oh: Ulsan National Institute of Science and Technology (UNIST)
Han Sol Kim: Ulsan National Institute of Science and Technology (UNIST)
L. Palanikumar: Ulsan National Institute of Science and Technology (UNIST)
Eun Min Go: Ulsan National Institute of Science and Technology (UNIST)
Batakrishna Jana: Ulsan National Institute of Science and Technology (UNIST)
Soo Ah Park: Ulsan National Institute of Science and Technology (UNIST)
Ho Young Kim: Ulsan National Institute of Science and Technology (UNIST)
Kibeom Kim: Ulsan National Institute of Science and Technology (UNIST)
Jeong Kon Seo: Ulsan National Institute of Science and Technology (UNIST)
Sang Kyu Kwak: Ulsan National Institute of Science and Technology (UNIST)
Chaekyu Kim: Ulsan National Institute of Science and Technology (UNIST)
Sebyung Kang: Ulsan National Institute of Science and Technology (UNIST)
Ja-Hyoung Ryu: Ulsan National Institute of Science and Technology (UNIST)

Nature Communications, 2018, vol. 9, issue 1, 1-9

Abstract: Abstract Targeted drug delivery using nanoparticles can minimize the side effects of conventional pharmaceutical agents and enhance their efficacy. However, translating nanoparticle-based agents into clinical applications still remains a challenge due to the difficulty in regulating interactions on the interfaces between nanoparticles and biological systems. Here, we present a targeting strategy for nanoparticles incorporated with a supramolecularly pre-coated recombinant fusion protein in which HER2-binding affibody combines with glutathione-S-transferase. Once thermodynamically stabilized in preferred orientations on the nanoparticles, the adsorbed fusion proteins as a corona minimize interactions with serum proteins to prevent the clearance of nanoparticles by macrophages, while ensuring systematic targeting functions in vitro and in vivo. This study provides insight into the use of the supramolecularly built protein corona shield as a targeting agent through regulating the interfaces between nanoparticles and biological systems.

Date: 2018
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DOI: 10.1038/s41467-018-06979-4

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