Self-implantable double-layered micro-drug-reservoirs for efficient and controlled ocular drug delivery

Aung Than, Chenghao Liu, Hao Chang, Phan Khanh Duong, Chui Ming Gemmy Cheung, Chenjie Xu (), Xiaomeng Wang () and Peng Chen ()
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Aung Than: Nanyang Technological University
Chenghao Liu: Nanyang Technological University
Hao Chang: Nanyang Technological University
Phan Khanh Duong: Nanyang Technological University
Chui Ming Gemmy Cheung: Singapore National Eye Centre
Chenjie Xu: Nanyang Technological University
Xiaomeng Wang: Nanyang Technological University
Peng Chen: Nanyang Technological University

Nature Communications, 2018, vol. 9, issue 1, 1-12

Abstract: Abstract Eye diseases and injuries impose a significant clinical problem worldwide. Safe and effective ocular drug delivery is, however, challenging due to the presence of ocular barriers. Here we report a strategy using an eye patch equipped with an array of detachable microneedles. These microneedles can penetrate the ocular surface tissue, and serve as implanted micro-reservoirs for controlled drug delivery. The biphasic drug release kinetics enabled by the double-layered micro-reservoirs largely enhances therapeutic efficacy. Using corneal neovascularization as the disease model, we show that delivery of an anti-angiogenic monoclonal antibody (DC101) by such eye patch produces ~90% reduction of neovascular area. Furthermore, quick release of an anti-inflammatory compound (diclofenac) followed by a sustained release of DC101 provides synergistic therapeutic outcome. The eye patch application is easy and minimally invasive to ensure good patient compliance. Such intraocular drug delivery strategy promises effective home-based treatment of many eye diseases.

Date: 2018
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DOI: 10.1038/s41467-018-06981-w

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