Programming molecular topologies from single-stranded nucleic acids

Xiaodong Qi, Fei Zhang (), Zhaoming Su, Shuoxing Jiang, Dongran Han, Baoquan Ding, Yan Liu, Wah Chiu, Peng Yin and Hao Yan ()
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Xiaodong Qi: Arizona State University
Fei Zhang: Arizona State University
Zhaoming Su: Stanford University
Shuoxing Jiang: Arizona State University
Dongran Han: Harvard Medical School
Baoquan Ding: CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, China
Yan Liu: Arizona State University
Wah Chiu: Stanford University
Peng Yin: Harvard Medical School
Hao Yan: Arizona State University

Nature Communications, 2018, vol. 9, issue 1, 1-9

Abstract: Abstract Molecular knots represent one of the most extraordinary topological structures in biological polymers. Creating highly knotted nanostructures with well-defined and sophisticated geometries and topologies remains challenging. Here, we demonstrate a general strategy to design and construct highly knotted nucleic acid nanostructures, each weaved from a single-stranded DNA or RNA chain by hierarchical folding in a prescribed order. Sets of DNA and RNA knots of two- or three-dimensional shapes have been designed and constructed (ranging from 1700 to 7500 nucleotides), and they exhibit complex topological features, with high crossing numbers (from 9 up to 57). These single-stranded DNA/RNA knots can be replicated and amplified enzymatically in vitro and in vivo. This work establishes a general platform for constructing nucleic acid nanostructures with complex molecular topologies.

Date: 2018
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DOI: 10.1038/s41467-018-07039-7

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