An oviduct-on-a-chip provides an enhanced in vitro environment for zygote genome reprogramming

Marcia A. M. M. Ferraz, Hoon Suk Rho, Daiane Hemerich, Heiko H. W. Henning, Helena T. A. Tol, Michael Hölker, Urban Besenfelder, Michal Mokry, Peter L. A. M. Vos, Tom A. E. Stout, Séverine Gac and Bart M. Gadella ()
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Marcia A. M. M. Ferraz: Utrecht University
Hoon Suk Rho: University of Twente
Daiane Hemerich: University Medical Center Utrecht
Heiko H. W. Henning: Utrecht University
Helena T. A. Tol: Utrecht University
Michael Hölker: University of Bonn
Urban Besenfelder: University of Veterinary Medicine Vienna
Michal Mokry: University Medical Center Utrecht
Peter L. A. M. Vos: Utrecht University
Tom A. E. Stout: Utrecht University
Séverine Gac: University of Twente
Bart M. Gadella: Utrecht University

Nature Communications, 2018, vol. 9, issue 1, 1-14

Abstract: Abstract Worldwide over 5 million children have been conceived using assisted reproductive technology, and research has concentrated on increasing the likelihood of ongoing pregnancy. However, studies using animal models have indicated undesirable effects of in vitro embryo culture on offspring development and health. In vivo, the oviduct hosts a period in which the early embryo undergoes complete reprogramming of its (epi)genome in preparation for the reacquisition of (epi)genetic marks. We designed an oviduct-on-a-chip platform to better investigate the mechanisms related to (epi)genetic reprogramming and the degree to which they differ between in vitro and in vivo embryos. The device supports more physiological (in vivo-like) zygote genetic reprogramming than conventional IVF. This approach will be instrumental in identifying and investigating factors critical to fertilization and pre-implantation development, which could improve the quality and (epi)genetic integrity of IVF zygotes with likely relevance for early embryonic and later fetal development.

Date: 2018
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DOI: 10.1038/s41467-018-07119-8

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