Whole body PD-1 and PD-L1 positron emission tomography in patients with non-small-cell lung cancer

A. N. Niemeijer, D. Leung, M. C. Huisman, I. Bahce, O. S. Hoekstra, G. A. M. S. Dongen, R. Boellaard, S. Du, W. Hayes, R. Smith, A. D. Windhorst, N. H. Hendrikse, A. Poot, D. J. Vugts, E. Thunnissen, P. Morin, D. Lipovsek, D. J. Donnelly, S. J. Bonacorsi, L. M. Velasquez, T. D. Gruijl, E. F. Smit and A. J. Langen ()
Additional contact information
A. N. Niemeijer: Amsterdam UMC, Vrije Universiteit Amsterdam
D. Leung: Bristol-Myers Squibb Research and Development
M. C. Huisman: Amsterdam UMC, Vrije Universiteit Amsterdam
I. Bahce: Amsterdam UMC, Vrije Universiteit Amsterdam
O. S. Hoekstra: Amsterdam UMC, Vrije Universiteit Amsterdam
G. A. M. S. Dongen: Amsterdam UMC, Vrije Universiteit Amsterdam
R. Boellaard: Amsterdam UMC, Vrije Universiteit Amsterdam
S. Du: Bristol-Myers Squibb Research and Development
W. Hayes: Bristol-Myers Squibb Research and Development
R. Smith: Bristol-Myers Squibb Research and Development
A. D. Windhorst: Amsterdam UMC, Vrije Universiteit Amsterdam
N. H. Hendrikse: Amsterdam UMC, Vrije Universiteit Amsterdam
A. Poot: Amsterdam UMC, Vrije Universiteit Amsterdam
D. J. Vugts: Amsterdam UMC, Vrije Universiteit Amsterdam
E. Thunnissen: Amsterdam UMC, Vrije Universiteit Amsterdam
P. Morin: Bristol-Myers Squibb Research and Development
D. Lipovsek: Bristol-Myers Squibb Research and Development
D. J. Donnelly: Bristol-Myers Squibb Research and Development
S. J. Bonacorsi: Bristol-Myers Squibb Research and Development
L. M. Velasquez: Bristol-Myers Squibb Research and Development
T. D. Gruijl: Amsterdam UMC, Vrije Universiteit Amsterdam
E. F. Smit: Netherlands Cancer Institute
A. J. Langen: Amsterdam UMC, Vrije Universiteit Amsterdam

Nature Communications, 2018, vol. 9, issue 1, 1-5

Abstract: Abstract PD-L1 immunohistochemistry correlates only moderately with patient survival and response to PD-(L)1 treatment. Heterogeneity of tumor PD-L1 expression might limit the predictive value of small biopsies. Here we show that tumor PD-L1 and PD-1 expression can be quantified non-invasively using PET-CT in patients with non-small-cell lung cancer. Whole body PD-(L)1 PET-CT reveals significant tumor tracer uptake heterogeneity both between patients, as well as within patients between different tumor lesions.

Date: 2018
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DOI: 10.1038/s41467-018-07131-y

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