Connectivity and network state-dependent recruitment of long-range VIP-GABAergic neurons in the mouse hippocampus

Ruggiero Francavilla, Vincent Villette, Xiao Luo, Simon Chamberland, Einer Muñoz-Pino, Olivier Camiré, Kristina Wagner, Viktor Kis, Peter Somogyi and Lisa Topolnik ()
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Ruggiero Francavilla: Université Laval
Vincent Villette: Université Laval
Xiao Luo: Université Laval
Simon Chamberland: Université Laval
Einer Muñoz-Pino: Université Laval
Olivier Camiré: Université Laval
Kristina Wagner: Oxford University
Viktor Kis: Oxford University
Peter Somogyi: Oxford University
Lisa Topolnik: Université Laval

Nature Communications, 2018, vol. 9, issue 1, 1-17

Abstract: Abstract GABAergic interneurons in the hippocampus provide for local and long-distance coordination of neurons in functionally connected areas. Vasoactive intestinal peptide-expressing (VIP+) interneurons occupy a distinct niche in circuitry as many of them specialize in innervating GABAergic cells, thus providing network disinhibition. In the CA1 hippocampus, VIP+ interneuron-selective cells target local interneurons. Here, we discover a type of VIP+ neuron whose axon innervates CA1 and also projects to the subiculum (VIP-LRPs). VIP-LRPs show specific molecular properties and target interneurons within the CA1 area but both interneurons and pyramidal cells within subiculum. They are interconnected through gap junctions but demonstrate sparse spike coupling in vitro. In awake mice, VIP-LRPs decrease their activity during theta-run epochs and are more active during quiet wakefulness but not coupled to sharp-wave ripples. Together, the data provide evidence for VIP interneuron molecular diversity and functional specialization in controlling cell ensembles along the hippocampo-subicular axis.

Date: 2018
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DOI: 10.1038/s41467-018-07162-5

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