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Non-obstructive intracellular nanolasers

Alasdair H. Fikouras, Marcel Schubert, Markus Karl, Jothi D. Kumar, Simon J. Powis, Andrea Di Falco () and Malte C. Gather ()
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Alasdair H. Fikouras: SUPA, School of Physics and Astronomy, University of St Andrews
Marcel Schubert: SUPA, School of Physics and Astronomy, University of St Andrews
Markus Karl: SUPA, School of Physics and Astronomy, University of St Andrews
Jothi D. Kumar: SUPA, School of Physics and Astronomy, University of St Andrews
Simon J. Powis: School of Medicine, University of St Andrews
Andrea Di Falco: SUPA, School of Physics and Astronomy, University of St Andrews
Malte C. Gather: SUPA, School of Physics and Astronomy, University of St Andrews

Nature Communications, 2018, vol. 9, issue 1, 1-7

Abstract: Abstract Molecular dyes, plasmonic nanoparticles and colloidal quantum dots are widely used in biomedical optics. Their operation is usually governed by spontaneous processes, which results in broad spectral features and limited signal-to-noise ratio, thus restricting opportunities for spectral multiplexing and sensing. Lasers provide the ultimate spectral definition and background suppression, and their integration with cells has recently been demonstrated. However, laser size and threshold remain problematic. Here, we report on the design, high-throughput fabrication and intracellular integration of semiconductor nanodisk lasers. By exploiting the large optical gain and high refractive index of GaInP/AlGaInP quantum wells, we obtain lasers with volumes 1000-fold smaller than the eukaryotic nucleus (Vlaser

Date: 2018
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DOI: 10.1038/s41467-018-07248-0

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