MR imaging tracking of inflammation-activatable engineered neutrophils for targeted therapy of surgically treated glioma

Meiying Wu, Haixian Zhang, Changjun Tie, Chunhong Yan, Zhiting Deng, Qian Wan, Xin Liu, Fei Yan () and Hairong Zheng ()
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Meiying Wu: Chinese Academy of Sciences
Haixian Zhang: Chinese Academy of Sciences
Changjun Tie: Chinese Academy of Sciences
Chunhong Yan: Chinese Academy of Sciences
Zhiting Deng: Chinese Academy of Sciences
Qian Wan: Chinese Academy of Sciences
Xin Liu: Chinese Academy of Sciences
Fei Yan: Chinese Academy of Sciences
Hairong Zheng: Chinese Academy of Sciences

Nature Communications, 2018, vol. 9, issue 1, 1-13

Abstract: Abstract Cell-based drug delivery systems have shown promising capability for tumor-targeted therapy owing to the intrinsic tumor-homing and drug-carrying property of some living cells. However, imaging tracking of their migration and bio-effects is urgently needed for clinical application, especially for glioma. Here, we report the inflammation-activatable engineered neutrophils by internalizing doxorubicin-loaded magnetic mesoporous silica nanoparticles (ND-MMSNs) which can provide the potential for magnetic resonance (MR) imaging tracking of the drug-loaded cells to actively target inflamed brain tumor after surgical resection of primary tumor. The phagocytized D-MMSNs possess high drug loading efficiency and do not affect the host neutrophils’ viability, thus remarkably improving intratumoral drug concentration and delaying relapse of surgically treated glioma. Our study offers a new strategy in targeted cancer theranostics through combining the merits of living cells and nanoparticle carriers.

Date: 2018
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DOI: 10.1038/s41467-018-07250-6

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