Engulfing cells promote neuronal regeneration and remove neuronal debris through distinct biochemical functions of CED-1

Hui Chiu, Yan Zou, Nobuko Suzuki, Yi-Wen Hsieh, Chiou-Fen Chuang, Yi-Chun Wu and Chieh Chang ()
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Hui Chiu: University of Illinois at Chicago
Yan Zou: University of Illinois at Chicago
Nobuko Suzuki: University of Illinois at Chicago
Yi-Wen Hsieh: University of Illinois at Chicago
Chiou-Fen Chuang: University of Illinois at Chicago
Yi-Chun Wu: National Taiwan University
Chieh Chang: University of Illinois at Chicago

Nature Communications, 2018, vol. 9, issue 1, 1-13

Abstract: Abstract Two important biological events happen coincidently soon after nerve injury in the peripheral nervous system in C. elegans: removal of axon debris and initiation of axon regeneration. But, it is not known how these two events are co-regulated. Mutants of ced-1, a homolog of Draper and MEGF10, display defects in both events. One model is that those events could be related. But our data suggest that they are actually separable. CED-1 functions in the muscle-type engulfing cells in both events and is enriched in muscle protrusions in close contact with axon debris and regenerating axons. Its two functions occur through distinct biochemical mechanisms; extracellular domain-mediated adhesion for regeneration and extracellular domain binding-induced intracellular domain signaling for debris removal. These studies identify CED-1 in engulfing cells as a receptor in debris removal but as an adhesion molecule in neuronal regeneration, and have important implications for understanding neural circuit repair after injury.

Date: 2018
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DOI: 10.1038/s41467-018-07291-x

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