Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling

Kathleen Hübner, Pauline Cabochette, Rodrigo Diéguez-Hurtado, Cora Wiesner, Yuki Wakayama, Kathrin S. Grassme, Marvin Hubert, Stefan Guenther, Heinz-Georg Belting, Markus Affolter, Ralf H. Adams, Benoit Vanhollebeke and Wiebke Herzog ()
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Kathleen Hübner: University of Muenster
Pauline Cabochette: Université libre de Bruxelles
Rodrigo Diéguez-Hurtado: Cells-in-Motion Cluster of Excellence (EXC 1003 – CiM), University of Muenster
Cora Wiesner: Biozentrum der Universität Basel
Yuki Wakayama: University of Muenster
Kathrin S. Grassme: University of Muenster
Marvin Hubert: University of Muenster
Stefan Guenther: Max Planck Institute for Heart and Lung Research, ECCPS Bioinformatics and Deep Sequencing Platform
Heinz-Georg Belting: Biozentrum der Universität Basel
Markus Affolter: Biozentrum der Universität Basel
Ralf H. Adams: Cells-in-Motion Cluster of Excellence (EXC 1003 – CiM), University of Muenster
Benoit Vanhollebeke: Université libre de Bruxelles
Wiebke Herzog: University of Muenster

Nature Communications, 2018, vol. 9, issue 1, 1-17

Abstract: Abstract Canonical Wnt signaling is crucial for vascularization of the central nervous system and blood-brain barrier (BBB) formation. BBB formation and modulation are not only important for development, but also relevant for vascular and neurodegenerative diseases. However, there is little understanding of how Wnt signaling contributes to brain angiogenesis and BBB formation. Here we show, using high resolution in vivo imaging and temporal and spatial manipulation of Wnt signaling, different requirements for Wnt signaling during brain angiogenesis and BBB formation. In the absence of Wnt signaling, premature Sphingosine-1-phosphate receptor (S1pr) signaling reduces VE-cadherin and Esama at cell-cell junctions. We suggest that Wnt signaling suppresses S1pr signaling during angiogenesis to enable the dynamic junction formation during anastomosis, whereas later S1pr signaling regulates BBB maturation and VE-cadherin stabilization. Our data provides a link between brain angiogenesis and BBB formation and identifies Wnt signaling as coordinator of the timing and as regulator of anastomosis.

Date: 2018
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DOI: 10.1038/s41467-018-07302-x

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