Interethnic analyses of blood pressure loci in populations of East Asian and European descent

Fumihiko Takeuchi, Masato Akiyama, Nana Matoba, Tomohiro Katsuya, Masahiro Nakatochi, Yasuharu Tabara, Akira Narita, Woei-Yuh Saw, Sanghoon Moon, Cassandra N. Spracklen, Jin-Fang Chai, Young-Jin Kim, Liang Zhang, Chaolong Wang, Huaixing Li, Honglan Li, Jer-Yuarn Wu, Rajkumar Dorajoo, Jovia L. Nierenberg, Ya Xing Wang, Jing He, Derrick A. Bennett, Atsushi Takahashi, Yukihide Momozawa, Makoto Hirata, Koichi Matsuda, Hiromi Rakugi, Eitaro Nakashima, Masato Isono, Matsuyuki Shirota, Atsushi Hozawa, Sahoko Ichihara, Tatsuaki Matsubara, Ken Yamamoto, Katsuhiko Kohara, Michiya Igase, Sohee Han, Penny Gordon-Larsen, Wei Huang, Nanette R. Lee, Linda S. Adair, Mi Yeong Hwang, Juyoung Lee, Miao Li Chee, Charumathi Sabanayagam, Wanting Zhao, Jianjun Liu, Dermot F. Reilly, Liang Sun, Shaofeng Huo, Todd L. Edwards, Jirong Long, Li-Ching Chang, Chien-Hsiun Chen, Jian-Min Yuan, Woon-Puay Koh, Yechiel Friedlander, Tanika N. Kelly, Wen Wei, Liang Xu, Hui Cai, Yong-Bing Xiang, Kuang Lin, Robert Clarke, Robin G. Walters, Iona Y. Millwood, Liming Li, John C. Chambers, Jaspal S. Kooner, Paul Elliott, Pim van der Harst, Zhengming Chen, Makoto Sasaki, Xiao-Ou Shu, Jost B. Jonas, Jiang He, Chew-Kiat Heng, Yuan-Tsong Chen, Wei Zheng, Xu Lin, Yik-Ying Teo, E-Shyong Tai, Ching-Yu Cheng, Tien Yin Wong, Xueling Sim, Karen L. Mohlke, Masayuki Yamamoto, Bong-Jo Kim, Tetsuro Miki, Toru Nabika, Mitsuhiro Yokota, Yoichiro Kamatani, Michiaki Kubo and Norihiro Kato ()
Additional contact information
Fumihiko Takeuchi: National Center for Global Health and Medicine
Masato Akiyama: RIKEN Center for Integrative Medical Sciences
Nana Matoba: RIKEN Center for Integrative Medical Sciences
Tomohiro Katsuya: Osaka University Graduate School of Medicine
Masahiro Nakatochi: Nagoya University Hospital
Yasuharu Tabara: Kyoto University Graduate School of Medicine
Akira Narita: Tohoku University
Woei-Yuh Saw: National University of Singapore and National University Health System
Sanghoon Moon: National Institute of Health
Cassandra N. Spracklen: University of North Carolina
Jin-Fang Chai: National University of Singapore and National University Health System
Young-Jin Kim: National Institute of Health
Liang Zhang: Singapore National Eye Centre
Chaolong Wang: Agency for Science, Technology and Research
Huaixing Li: University of the Chinese Academy of Sciences, Chinese Academy of Sciences
Honglan Li: Shanghai Jiaotong University School of Medicine
Jer-Yuarn Wu: Academia Sinica
Rajkumar Dorajoo: Agency for Science, Technology and Research
Jovia L. Nierenberg: Tulane University School of Public Health and Tropical Medicine
Ya Xing Wang: Capital Medical University
Jing He: Vanderbilt University Medical Center
Derrick A. Bennett: University of Oxford
Atsushi Takahashi: RIKEN Center for Integrative Medical Sciences
Yukihide Momozawa: RIKEN Center for Integrative Medical Sciences
Makoto Hirata: The University of Tokyo
Koichi Matsuda: The University of Tokyo
Hiromi Rakugi: Osaka University Graduate School of Medicine
Eitaro Nakashima: Nagoya University Graduate School of Medicine
Masato Isono: National Center for Global Health and Medicine
Matsuyuki Shirota: Tohoku University
Atsushi Hozawa: Tohoku University
Sahoko Ichihara: Jichi Medical University School of Medicine
Tatsuaki Matsubara: Aichi Gakuin University
Ken Yamamoto: Kurume University School of Medicine
Katsuhiko Kohara: Ehime University
Michiya Igase: Ehime University Graduate School of Medicine
Sohee Han: National Institute of Health
Penny Gordon-Larsen: University of North Carolina at Chapel Hill
Wei Huang: Chinese National Human Genome Center and Shanghai Industrial Technology Institute (SITI)
Nanette R. Lee: University of San Carlos
Linda S. Adair: University of North Carolina at Chapel Hill
Mi Yeong Hwang: National Institute of Health
Juyoung Lee: National Institute of Health
Miao Li Chee: Singapore National Eye Centre
Charumathi Sabanayagam: Singapore National Eye Centre
Wanting Zhao: Singapore National Eye Centre
Jianjun Liu: Agency for Science, Technology and Research
Dermot F. Reilly: Merck Sharp Dohme Corp
Liang Sun: University of the Chinese Academy of Sciences, Chinese Academy of Sciences
Shaofeng Huo: University of the Chinese Academy of Sciences, Chinese Academy of Sciences
Todd L. Edwards: Vanderbilt University Medical Center
Jirong Long: Vanderbilt University Medical Center
Li-Ching Chang: Academia Sinica
Chien-Hsiun Chen: Academia Sinica
Jian-Min Yuan: University of Pittsburgh
Woon-Puay Koh: National University of Singapore and National University Health System
Yechiel Friedlander: Hebrew University-Hadassah Braun School of Public Health
Tanika N. Kelly: Tulane University School of Public Health and Tropical Medicine
Wen Wei: Capital Medical University
Liang Xu: Capital Medical University
Hui Cai: Vanderbilt University Medical Center
Yong-Bing Xiang: Shanghai Jiaotong University School of Medicine
Kuang Lin: University of Oxford
Robert Clarke: University of Oxford
Robin G. Walters: University of Oxford
Iona Y. Millwood: University of Oxford
Liming Li: Chinese Academy of Medical Sciences
John C. Chambers: Imperial College London
Jaspal S. Kooner: Imperial College London
Paul Elliott: Imperial College London
Pim van der Harst: University Medical Center Groningen
Zhengming Chen: University of Oxford
Makoto Sasaki: Iwate Tohoku Medical Megabank Organization
Xiao-Ou Shu: Vanderbilt University Medical Center
Jost B. Jonas: Capital Medical University
Jiang He: Tulane University School of Public Health and Tropical Medicine
Chew-Kiat Heng: National University of Singapore
Yuan-Tsong Chen: Academia Sinica
Wei Zheng: Vanderbilt University Medical Center
Xu Lin: University of the Chinese Academy of Sciences, Chinese Academy of Sciences
Yik-Ying Teo: National University of Singapore and National University Health System
E-Shyong Tai: National University of Singapore and National University Health System
Ching-Yu Cheng: Singapore National Eye Centre
Tien Yin Wong: Singapore National Eye Centre
Xueling Sim: National University of Singapore and National University Health System
Karen L. Mohlke: University of North Carolina
Masayuki Yamamoto: Tohoku University
Bong-Jo Kim: National Institute of Health
Tetsuro Miki: Ehime University Graduate School of Medicine
Toru Nabika: Shimane University Faculty of Medicine
Mitsuhiro Yokota: Aichi Gakuin University
Yoichiro Kamatani: RIKEN Center for Integrative Medical Sciences
Michiaki Kubo: RIKEN Center for Integrative Medical Sciences
Norihiro Kato: National Center for Global Health and Medicine

Nature Communications, 2018, vol. 9, issue 1, 1-16

Abstract: Abstract Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP.

Date: 2018
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DOI: 10.1038/s41467-018-07345-0

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