Systematic review of indoor residual spray efficacy and effectiveness against Plasmodium falciparum in Africa

Ellie Sherrard-Smith (), Jamie T. Griffin, Peter Winskill, Vincent Corbel, Cédric Pennetier, Armel Djénontin, Sarah Moore, Jason H. Richardson, Pie Müller, Constant Edi, Natacha Protopopoff, Richard Oxborough, Fiacre Agossa, Raphael N’Guessan, Mark Rowland and Thomas S. Churcher
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Ellie Sherrard-Smith: Imperial College London
Jamie T. Griffin: Queen Mary University of London
Peter Winskill: Imperial College London
Vincent Corbel: University of Montpellier
Cédric Pennetier: University of Montpellier
Armel Djénontin: Université d’Abomey-Calavi
Sarah Moore: Swiss Tropical and Public Health Institute
Jason H. Richardson: Innovative Vector Control Consortium
Pie Müller: Swiss Tropical and Public Health Institute
Constant Edi: Centre Suisse de Recherches Scientifiques en Cote d’Ivoire
Natacha Protopopoff: London School of Hygiene and Tropical Medicine
Richard Oxborough: Abt Associates
Fiacre Agossa: Centre de Recherche Entomologique de Cotonou (CREC)
Raphael N’Guessan: London School of Hygiene and Tropical Medicine
Mark Rowland: London School of Hygiene and Tropical Medicine
Thomas S. Churcher: Imperial College London

Nature Communications, 2018, vol. 9, issue 1, 1-13

Abstract: Abstract Indoor residual spraying (IRS) is an important part of malaria control. There is a growing list of insecticide classes; pyrethroids remain the principal insecticide used in bednets but recently, novel non-pyrethroid IRS products, with contrasting impacts, have been introduced. There is an urgent need to better assess product efficacy to help decision makers choose effective and relevant tools for mosquito control. Here we use experimental hut trial data to characterise the entomological efficacy of widely-used, novel IRS insecticides. We quantify their impact against pyrethroid-resistant mosquitoes and use a Plasmodium falciparum transmission model to predict the public health impact of different IRS insecticides. We report that long-lasting IRS formulations substantially reduce malaria, though their benefit over cheaper, shorter-lived formulations depends on local factors including bednet use, seasonality, endemicity and pyrethroid resistance status of local mosquito populations. We provide a framework to help decision makers evaluate IRS product effectiveness.

Date: 2018
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DOI: 10.1038/s41467-018-07357-w

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