Downregulation of macrophage Irs2 by hyperinsulinemia impairs IL-4-indeuced M2a-subtype macrophage activation in obesity

Tetsuya Kubota, Mariko Inoue, Naoto Kubota (), Iseki Takamoto, Tomoka Mineyama, Kaito Iwayama, Kumpei Tokuyama, Masao Moroi, Kohjiro Ueki, Toshimasa Yamauchi and Takashi Kadowaki ()
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Tetsuya Kubota: The University of Tokyo
Mariko Inoue: The University of Tokyo
Naoto Kubota: The University of Tokyo
Iseki Takamoto: The University of Tokyo
Tomoka Mineyama: The University of Tokyo
Kaito Iwayama: University of Tsukuba
Kumpei Tokuyama: University of Tsukuba
Masao Moroi: Toho University Ohashi Medical Center
Kohjiro Ueki: The University of Tokyo
Toshimasa Yamauchi: The University of Tokyo
Takashi Kadowaki: The University of Tokyo

Nature Communications, 2018, vol. 9, issue 1, 1-15

Abstract: Abstract M2a-subtype macrophage activation is known to be impaired in obesity, although the underlying mechanisms remain poorly understood. Herein, we demonstrate that, the IL-4/Irs2/Akt pathway is selectively impaired, along with decreased macrophage Irs2 expression, although IL-4/STAT6 pathway is maintained. Indeed, myeloid cell-specific Irs2-deficient mice show impairment of IL-4-induced M2a-subtype macrophage activation, as a result of stabilization of the FoxO1/HDAC3/NCoR1 corepressor complex, resulting in insulin resistance under the HF diet condition. Moreover, the reduction of macrophage Irs2 expression is mediated by hyperinsulinemia via the insulin receptor (IR). In myeloid cell-specific IR-deficient mice, the IL-4/Irs2 pathway is preserved in the macrophages, which results in a reduced degree of insulin resistance, because of the lack of IR-mediated downregulation of Irs2. We conclude that downregulation of Irs2 in macrophages caused by hyperinsulinemia is responsible for systemic insulin resistance via impairment of M2a-subtype macrophage activation in obesity.

Date: 2018
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DOI: 10.1038/s41467-018-07358-9

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