Memory formation and long-term maintenance of IL-7Rα+ ILC1s via a lymph node-liver axis

Xianwei Wang, Hui Peng (), Jingjing Cong, Xuefu Wang, Zhexiong Lian, Haiming Wei, Rui Sun () and Zhigang Tian ()
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Xianwei Wang: University of Science and Technology of China
Hui Peng: University of Science and Technology of China
Jingjing Cong: University of Science and Technology of China
Xuefu Wang: University of Science and Technology of China
Zhexiong Lian: University of Science and Technology of China
Haiming Wei: University of Science and Technology of China
Rui Sun: University of Science and Technology of China
Zhigang Tian: University of Science and Technology of China

Nature Communications, 2018, vol. 9, issue 1, 1-12

Abstract: Abstract Natural killer (NK) cells are reported to have immunological memory, with CD49a+ liver-resident NK cells shown to confer hapten-specific memory responses, but how this memory is induced or maintained is unclear. Here we show that memory type I innate lymphoid cells (ILC1s), which express IL-7Rα, are generated in the lymph nodes (LNs) and require IL-7R signaling to maintain their longevity in the liver. Hapten sensitization initiates CXCR3-dependent recruitment of IL-7Rα+ ILC1s into skin-draining LNs, where they are primed and acquire hapten-specific memory potential. Memory IL-7Rα+ ILC1s then exit draining LNs and are preferentially recruited, via CXCR6, to reside in the liver. Moreover, long-term blockade of IL-7R signaling significantly reduces ILC1-mediated memory responses. Thus, our results identify a memory IL-7Rα+ ILC1 population and reveal a LN-liver axis that is essential for ILC1 memory generation and long-term maintenance.

Date: 2018
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DOI: 10.1038/s41467-018-07405-5

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