Synergistic enzymatic and bioorthogonal reactions for selective prodrug activation in living systems

Qingxin Yao, Feng Lin, Xinyuan Fan, Yanpu Wang, Ye Liu, Zhaofei Liu, Xingyu Jiang, Peng R. Chen () and Yuan Gao ()
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Qingxin Yao: National Center for Nanoscience and Technology
Feng Lin: Peking University
Xinyuan Fan: Peking University
Yanpu Wang: Peking University
Ye Liu: National Center for Nanoscience and Technology
Zhaofei Liu: Peking University
Xingyu Jiang: National Center for Nanoscience and Technology
Peng R. Chen: Peking University
Yuan Gao: National Center for Nanoscience and Technology

Nature Communications, 2018, vol. 9, issue 1, 1-9

Abstract: Abstract Adverse drug reactions (ADRs) restrict the maximum doses applicable in chemotherapy, which leads to failure in cancer treatment. Various approaches, including nano-drug and prodrug strategies aimed at reducing ADRs, have been developed, but these strategies have their own pitfalls. A renovated strategy for ADR reduction is urgently needed. Here, we employ an enzymatic supramolecular self-assembly process to accumulate a bioorthogonal decaging reaction trigger inside targeted cancer cells, enabling spatiotemporally controlled, synergistic prodrug activation. The bioorthogonally activated prodrug exhibits significantly enhanced potency against cancer cells compared with normal cells. This prodrug activation strategy further demonstrates high tumour inhibition efficacy with satisfactory biocompatibility, pharmacokinetics, and safety in vivo. We envision that integration of enzymatic and bioorthogonal reactions will serve as a general small-molecule-based strategy for alleviation of ADRs in chemotherapy.

Date: 2018
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DOI: 10.1038/s41467-018-07490-6

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