Shavenbaby and Yorkie mediate Hippo signaling to protect adult stem cells from apoptosis

Jérôme Bohère, Alexandra Mancheno-Ferris, Sandy Al Hayek, Jennifer Zanet, Philippe Valenti, Kohsuke Akino, Yuya Yamabe, Sachi Inagaki, Hélène Chanut-Delalande, Serge Plaza, Yuji Kageyama, Dani Osman, Cédric Polesello () and François Payre ()
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Jérôme Bohère: Université de Toulouse
Alexandra Mancheno-Ferris: Université de Toulouse
Sandy Al Hayek: Université de Toulouse
Jennifer Zanet: Université de Toulouse
Philippe Valenti: Université de Toulouse
Kohsuke Akino: Graduate School of Science
Yuya Yamabe: Graduate School of Science
Sachi Inagaki: Kobe University
Hélène Chanut-Delalande: Université de Toulouse
Serge Plaza: Université de Toulouse
Yuji Kageyama: Graduate School of Science
Dani Osman: Lebanese University
Cédric Polesello: Université de Toulouse
François Payre: Université de Toulouse

Nature Communications, 2018, vol. 9, issue 1, 1-12

Abstract: Abstract To compensate for accumulating damages and cell death, adult homeostasis (e.g., body fluids and secretion) requires organ regeneration, operated by long-lived stem cells. How stem cells can survive throughout the animal life remains poorly understood. Here we show that the transcription factor Shavenbaby (Svb, OvoL in vertebrates) is expressed in renal/nephric stem cells (RNSCs) of Drosophila and required for their maintenance during adulthood. As recently shown in embryos, Svb function in adult RNSCs further needs a post-translational processing mediated by the Polished rice (Pri) smORF peptides and impairing Svb function leads to RNSC apoptosis. We show that Svb interacts both genetically and physically with Yorkie (YAP/TAZ in vertebrates), a nuclear effector of the Hippo pathway, to activate the expression of the inhibitor of apoptosis DIAP1. These data therefore identify Svb as a nuclear effector in the Hippo pathway, critical for the survival of adult somatic stem cells.

Date: 2018
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DOI: 10.1038/s41467-018-07569-0

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