Nanoribbons self-assembled from short peptides demonstrate the formation of polar zippers between β-sheets

Meng Wang, Jiqian Wang (), Peng Zhou, Jing Deng, Yurong Zhao, Yawei Sun, Wei Yang, Dong Wang, Zongyi Li, Xuzhi Hu, Stephen M. King, Sarah E. Rogers, Henry Cox, Thomas A. Waigh, Jun Yang, Jian Ren Lu () and Hai Xu ()
Additional contact information
Meng Wang: China University of Petroleum (East China)
Jiqian Wang: China University of Petroleum (East China)
Peng Zhou: China University of Petroleum (East China)
Jing Deng: Chinese Academy of Sciences
Yurong Zhao: China University of Petroleum (East China)
Yawei Sun: China University of Petroleum (East China)
Wei Yang: China University of Petroleum (East China)
Dong Wang: China University of Petroleum (East China)
Zongyi Li: The University of Manchester
Xuzhi Hu: The University of Manchester
Stephen M. King: STFC Rutherford Appleton Laboratory
Sarah E. Rogers: STFC Rutherford Appleton Laboratory
Henry Cox: The University of Manchester
Thomas A. Waigh: The University of Manchester
Jun Yang: Chinese Academy of Sciences
Jian Ren Lu: The University of Manchester
Hai Xu: China University of Petroleum (East China)

Nature Communications, 2018, vol. 9, issue 1, 1-11

Abstract: Abstract Peptide self-assembly is a hierarchical process, often starting with the formation of α-helices, β-sheets or β-hairpins. However, how the secondary structures undergo further assembly to form higher-order architectures remains largely unexplored. The polar zipper originally proposed by Perutz is formed between neighboring β-strands of poly-glutamine via their side-chain hydrogen bonding and helps to stabilize the sheet. By rational design of short amphiphilic peptides and their self-assembly, here we demonstrate the formation of polar zippers between neighboring β-sheets rather than between β-strands within a sheet, which in turn intermesh the β-sheets into wide and flat ribbons. Such a super-secondary structural template based on well-defined hydrogen bonds could offer an agile route for the construction of distinctive nanostructures and nanomaterials beyond β-sheets.

Date: 2018
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-018-07583-2 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07583-2

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-018-07583-2

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().