Birth mode is associated with earliest strain-conferred gut microbiome functions and immunostimulatory potential

Linda Wampach, Anna Heintz-Buschart, Joëlle V. Fritz, Javier Ramiro-Garcia, Janine Habier, Malte Herold, Shaman Narayanasamy, Anne Kaysen, Angela H. Hogan, Lutz Bindl, Jean Bottu, Rashi Halder, Conny Sjöqvist, Patrick May, Anders F. Andersson, Carine Beaufort and Paul Wilmes ()
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Linda Wampach: University of Luxembourg
Anna Heintz-Buschart: University of Luxembourg
Joëlle V. Fritz: University of Luxembourg
Javier Ramiro-Garcia: University of Luxembourg
Janine Habier: University of Luxembourg
Malte Herold: University of Luxembourg
Shaman Narayanasamy: University of Luxembourg
Anne Kaysen: University of Luxembourg
Angela H. Hogan: Integrated BioBank of Luxembourg
Lutz Bindl: Centre Hospitalier de Luxembourg
Jean Bottu: Centre Hospitalier de Luxembourg
Rashi Halder: University of Luxembourg
Conny Sjöqvist: KTH Royal Institute of Technology, Science for Life Laboratory, School of Biotechnology, Division of Gene Technology
Patrick May: University of Luxembourg
Anders F. Andersson: KTH Royal Institute of Technology, Science for Life Laboratory, School of Biotechnology, Division of Gene Technology
Carine Beaufort: Centre Hospitalier de Luxembourg
Paul Wilmes: University of Luxembourg

Nature Communications, 2018, vol. 9, issue 1, 1-14

Abstract: Abstract The rate of caesarean section delivery (CSD) is increasing worldwide. It remains unclear whether disruption of mother-to-neonate transmission of microbiota through CSD occurs and whether it affects human physiology. Here we perform metagenomic analysis of earliest gut microbial community structures and functions. We identify differences in encoded functions between microbiomes of vaginally delivered (VD) and CSD neonates. Several functional pathways are over-represented in VD neonates, including lipopolysaccharide (LPS) biosynthesis. We link these enriched functions to individual-specific strains, which are transmitted from mothers to neonates in case of VD. The stimulation of primary human immune cells with LPS isolated from early stool samples of VD neonates results in higher levels of tumour necrosis factor (TNF-α) and interleukin 18 (IL-18). Accordingly, the observed levels of TNF-α and IL-18 in neonatal blood plasma are higher after VD. Taken together, our results support that CSD disrupts mother-to-neonate transmission of specific microbial strains, linked functional repertoires and immune-stimulatory potential during a critical window for neonatal immune system priming.

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07631-x

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DOI: 10.1038/s41467-018-07631-x

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