SUMO conjugation to the pattern recognition receptor FLS2 triggers intracellular signalling in plant innate immunity

Beatriz Orosa, Gary Yates, Vivek Verma, Anjil K. Srivastava, Moumita Srivastava, Alberto Campanaro, Daniel Vega, Alanna Fernandes, Cunjin Zhang, Jack Lee, Malcolm J. Bennett and Ari Sadanandom ()
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Beatriz Orosa: Durham University
Gary Yates: Durham University
Vivek Verma: Durham University
Anjil K. Srivastava: Durham University
Moumita Srivastava: Durham University
Alberto Campanaro: Durham University
Daniel Vega: Durham University
Alanna Fernandes: Durham University
Cunjin Zhang: Durham University
Jack Lee: Durham University
Malcolm J. Bennett: University of Nottingham
Ari Sadanandom: Durham University

Nature Communications, 2018, vol. 9, issue 1, 1-12

Abstract: Abstract Detection of conserved microbial patterns by host cell surface pattern recognition receptors (PRRs) activates innate immunity. The FLAGELLIN-SENSITIVE 2 (FLS2) receptor perceives bacterial flagellin and recruits another PRR, BAK1 and the cytoplasmic-kinase BIK1 to form an active co-receptor complex that initiates antibacterial immunity in Arabidopsis. Molecular mechanisms that transmit flagellin perception from the plasma-membrane FLS2-associated receptor complex to intracellular events are less well understood. Here, we show that flagellin induces the conjugation of the SMALL UBIQUITIN-LIKE MODIFIER (SUMO) protein to FLS2 to trigger release of BIK1. Disruption of FLS2 SUMOylation can abolish immune responses, resulting in susceptibility to bacterial pathogens in Arabidopsis. We also identify the molecular machinery that regulates FLS2 SUMOylation and demonstrate a role for the deSUMOylating enzyme, Desi3a in innate immunity. Flagellin induces the degradation of Desi3a and enhances FLS2 SUMOylation to promote BIK1 dissociation and trigger intracellular immune signalling.

Date: 2018
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DOI: 10.1038/s41467-018-07696-8

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