Spatial fine-mapping for gene-by-environment effects identifies risk hot spots for schizophrenia

Chun Chieh Fan, John J. McGrath, Vivek Appadurai, Alfonso Buil, Michael J. Gandal, Andrew J. Schork, Preben Bo Mortensen, Esben Agerbo, Sandy A. Geschwind, Daniel Geschwind, Thomas Werge, Wesley K. Thompson () and Carsten Bøcker Pedersen ()
Additional contact information
Chun Chieh Fan: University of California
John J. McGrath: Aarhus University
Vivek Appadurai: Capital Region of Denmark
Alfonso Buil: Capital Region of Denmark
Michael J. Gandal: University of California
Andrew J. Schork: Capital Region of Denmark
Preben Bo Mortensen: Aarhus University
Esben Agerbo: Aarhus University
Sandy A. Geschwind: Scientific Decision Consulting
Daniel Geschwind: University of California
Thomas Werge: Capital Region of Denmark
Wesley K. Thompson: Capital Region of Denmark
Carsten Bøcker Pedersen: Aarhus University

Nature Communications, 2018, vol. 9, issue 1, 1-7

Abstract: Abstract Spatial mapping is a promising strategy to investigate the mechanisms underlying the incidence of psychosis. We analyzed a case-cohort study (n = 24,028), drawn from the 1.47 million Danish persons born between 1981 and 2005, using a novel framework for decomposing the geospatial risk for schizophrenia based on locale of upbringing and polygenic scores. Upbringing in a high environmental risk locale increases the risk for schizophrenia by 122%. Individuals living in a high gene-by-environmental risk locale have a 78% increased risk compared to those who have the same genetic liability but live in a low-risk locale. Effects of specific locales vary substantially within the most densely populated city of Denmark, with hazard ratios ranging from 0.26 to 9.26 for environment and from 0.20 to 5.95 for gene-by-environment. These findings indicate the critical synergism of gene and environment on the etiology of schizophrenia and demonstrate the potential of incorporating geolocation in genetic studies.

Date: 2018
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-018-07708-7 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07708-7

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-018-07708-7

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().