Genomic insights into multidrug-resistance, mating and virulence in Candida auris and related emerging species

José F. Muñoz, Lalitha Gade, Nancy A. Chow, Vladimir N. Loparev, Phalasy Juieng, Elizabeth L. Berkow, Rhys A. Farrer, Anastasia P. Litvintseva () and Christina A. Cuomo ()
Additional contact information
José F. Muñoz: Broad Institute of MIT and Harvard
Lalitha Gade: Centers for Disease Control and Prevention
Nancy A. Chow: Centers for Disease Control and Prevention
Vladimir N. Loparev: Centers for Disease Control and Prevention
Phalasy Juieng: Centers for Disease Control and Prevention
Elizabeth L. Berkow: Centers for Disease Control and Prevention
Rhys A. Farrer: Broad Institute of MIT and Harvard
Anastasia P. Litvintseva: Centers for Disease Control and Prevention
Christina A. Cuomo: Broad Institute of MIT and Harvard

Nature Communications, 2018, vol. 9, issue 1, 1-13

Abstract: Abstract Candida auris is an emergent multidrug-resistant fungal pathogen causing increasing reports of outbreaks. While distantly related to C. albicans and C. glabrata, C. auris is closely related to rarely observed and often multidrug-resistant species from the C. haemulonii clade. Here, we analyze near complete genome assemblies for the four C. auris clades and three related species, and map intra- and inter-species rearrangements across the seven chromosomes. Using RNA-Seq-guided gene predictions, we find that most mating and meiosis genes are conserved and that clades contain either the MTLa or MTLα mating loci. Comparing the genomes of these emerging species to those of other Candida species identifies genes linked to drug resistance and virulence, including expanded families of transporters and lipases, as well as mutations and copy number variants in ERG11. Gene expression analysis identifies transporters and metabolic regulators specific to C. auris and those conserved with related species which may contribute to differences in drug response in this emerging fungal clade.

Date: 2018
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-018-07779-6 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07779-6

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-018-07779-6

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().