Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice

Dalong Ni, Dawei Jiang, Christopher J. Kutyreff, Jianhao Lai, Yongjun Yan, Todd E. Barnhart, Bo Yu, Hyung-Jun Im, Lei Kang, Steve Y. Cho, Zhaofei Liu (), Peng Huang, Jonathan W. Engle and Weibo Cai ()
Additional contact information
Dalong Ni: University of Wisconsin
Dawei Jiang: University of Wisconsin
Christopher J. Kutyreff: University of Wisconsin
Jianhao Lai: University of Wisconsin
Yongjun Yan: University of Wisconsin
Todd E. Barnhart: University of Wisconsin
Bo Yu: University of Wisconsin
Hyung-Jun Im: University of Wisconsin
Lei Kang: University of Wisconsin
Steve Y. Cho: University of Wisconsin
Zhaofei Liu: Peking University Health Science Center
Peng Huang: Shenzhen University
Jonathan W. Engle: University of Wisconsin
Weibo Cai: University of Wisconsin

Nature Communications, 2018, vol. 9, issue 1, 1-11

Abstract: Abstract Acute kidney injury (AKI) is a common reactive oxygen species (ROS)-related renal disease that causes numerous deaths annually, yet only supportive treatment is currently available in the clinics. Development of antioxidants with high accumulation rates in kidneys is highly desired to help prevent AKI. Here we report molybdenum-based polyoxometalate (POM) nanoclusters with preferential renal uptake as novel nano-antioxidants for kidney protection. These POM nanoclusters, with a readily variable valence state of molybdenum ions, possess the capability to scavenge detrimental ROS. Our results demonstrate that POM nanoclusters can efficiently alleviate clinical symptoms in mice subjected to AKI, as verified by dynamic PET imaging with 68Ga-EDTA, serum tests, kidney tissue staining, and biomarkers detection in the kidneys. The protective effect of POM nanoclusters against AKI in living animals suggests exploring their use for the treatment of AKI patients, as well as patients with other ROS-related diseases.

Date: 2018
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-018-07890-8 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07890-8

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-018-07890-8

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().