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RETRACTED ARTICLE: Machine learning of neural representations of suicide and emotion concepts identifies suicidal youth

Marcel Adam Just (), Lisa Pan, Vladimir L. Cherkassky, Dana L. McMakin, Christine Cha, Matthew K. Nock and David Brent
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Marcel Adam Just: Carnegie Mellon University
Lisa Pan: University of Pittsburgh School of Medicine
Vladimir L. Cherkassky: Carnegie Mellon University
Dana L. McMakin: Florida International University
Christine Cha: Columbia University
Matthew K. Nock: Harvard University
David Brent: University of Pittsburgh School of Medicine

Nature Human Behaviour, 2017, vol. 1, issue 12, 911-919

Abstract: Abstract The clinical assessment of suicidal risk would be substantially complemented by a biologically based measure that assesses alterations in the neural representations of concepts related to death and life in people who engage in suicidal ideation. This study used machine-learning algorithms (Gaussian Naive Bayes) to identify such individuals (17 suicidal ideators versus 17 controls) with high (91%) accuracy, based on their altered functional magnetic resonance imaging neural signatures of death-related and life-related concepts. The most discriminating concepts were ‘death’, ‘cruelty’, ‘trouble’, ‘carefree’, ‘good’ and ‘praise’. A similar classification accurately (94%) discriminated nine suicidal ideators who had made a suicide attempt from eight who had not. Moreover, a major facet of the concept alterations was the evoked emotion, whose neural signature served as an alternative basis for accurate (85%) group classification. This study establishes a biological, neurocognitive basis for altered concept representations in participants with suicidal ideation, which enables highly accurate group membership classification.

Date: 2017
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DOI: 10.1038/s41562-017-0234-y

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