Exome sequencing of healthy phenotypic extremes links TROVE2 to emotional memory and PTSD

Angela Heck (), Annette Milnik, Vanja Vukojevic, Jana Petrovska, Tobias Egli, Jochen Singer, Pablo Escobar, Thierry Sengstag, David Coynel, Virginie Freytag, Matthias Fastenrath, Philippe Demougin, Eva Loos, Francina Hartmann, Nathalie Schicktanz, Bernardo Delarue Bizzini, Christian Vogler, Iris-Tatjana Kolassa, Sarah Wilker, Thomas Elbert, Torsten Schwede, Christian Beisel, Niko Beerenwinkel, Dominique J.-F. de Quervain and Andreas Papassotiropoulos ()
Additional contact information
Angela Heck: University of Basel
Annette Milnik: University of Basel
Vanja Vukojevic: University of Basel
Jana Petrovska: University of Basel
Tobias Egli: University of Basel
Jochen Singer: ETH Zurich
Pablo Escobar: SIB Swiss Institute of Bioinformatics
Thierry Sengstag: SIB Swiss Institute of Bioinformatics
David Coynel: Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel
Virginie Freytag: University of Basel
Matthias Fastenrath: Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel
Philippe Demougin: University of Basel
Eva Loos: Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel
Francina Hartmann: University of Basel
Nathalie Schicktanz: Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel
Bernardo Delarue Bizzini: University of Basel
Christian Vogler: University of Basel
Iris-Tatjana Kolassa: Clinical & Biological Psychology, Institute of Psychology & Education, Ulm University
Sarah Wilker: Clinical & Biological Psychology, Institute of Psychology & Education, Ulm University
Thomas Elbert: University of Konstanz
Torsten Schwede: SIB Swiss Institute of Bioinformatics
Christian Beisel: ETH Zurich
Niko Beerenwinkel: ETH Zurich
Dominique J.-F. de Quervain: Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel
Andreas Papassotiropoulos: University of Basel

Nature Human Behaviour, 2017, vol. 1, issue 4, 1-10

Abstract: Abstract Many mental disorders represent the extremes of the normal distribution of traits, which are related to multiple cognitive and emotional dimensions. By performing whole-exome sequencing of healthy, young subjects with extremely high versus extremely low aversive memory performance, we identified TROVE2 as a gene implicated in emotional memory in health and disease. TROVE2 encodes Ro60, a broadly expressed RNA-binding protein implicated in the regulation of inflammatory gene expression and autoimmunity. A regulatory TROVE2 variant was linked to higher emotional memory capacity and higher emotional memory-related brain activation in healthy subjects. In addition, TROVE2 was associated with traumatic memory and the frequency of post-traumatic stress disorder in genocide survivors.

Date: 2017
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41562-017-0081 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nathum:v:1:y:2017:i:4:d:10.1038_s41562-017-0081

Ordering information: This journal article can be ordered from
https://www.nature.com/nathumbehav/

DOI: 10.1038/s41562-017-0081

Access Statistics for this article

Nature Human Behaviour is currently edited by Stavroula Kousta

More articles in Nature Human Behaviour from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().