Identification of neurobehavioural symptom groups based on shared brain mechanisms

Alex Ing, Philipp G. Sämann, Congying Chu, Nicole Tay, Francesca Biondo, Gabriel Robert, Tianye Jia, Thomas Wolfers, Sylvane Desrivières, Tobias Banaschewski, Arun L. W. Bokde, Uli Bromberg, Christian Büchel, Patricia Conrod, Tahmine Fadai, Herta Flor, Vincent Frouin, Hugh Garavan, Philip A. Spechler, Penny Gowland, Yvonne Grimmer, Andreas Heinz, Bernd Ittermann, Viola Kappel, Jean-Luc Martinot, Andreas Meyer-Lindenberg, Sabina Millenet, Frauke Nees, Betteke Noort, Dimitri Papadopoulos Orfanos, Marie-Laure Paillère Martinot, Jani Penttilä, Luise Poustka, Erin Burke Quinlan, Michael N. Smolka, Argyris Stringaris, Maren Struve, Ilya M. Veer, Henrik Walter, Robert Whelan, Ole A. Andreassen, Ingrid Agartz, Hervé Lemaitre, Edward D. Barker, John Ashburner, Elisabeth Binder, Jan Buitelaar, Andre Marquand, Trevor W. Robbins and Gunter Schumann ()
Additional contact information
Alex Ing: King’s College London
Philipp G. Sämann: Max Planck Institute of Psychiatry
Congying Chu: King’s College London
Nicole Tay: King’s College London
Francesca Biondo: King’s College London
Gabriel Robert: King’s College London
Tianye Jia: King’s College London
Thomas Wolfers: Radboud University Nijmegen
Sylvane Desrivières: King’s College London
Tobias Banaschewski: Heidelberg University
Arun L. W. Bokde: Trinity College Dublin
Uli Bromberg: University Medical Centre Hamburg−Eppendorf
Christian Büchel: University Medical Centre Hamburg−Eppendorf
Patricia Conrod: Institute of Psychiatry, Psychology & Neuroscience King’s College London
Tahmine Fadai: University Medical Centre Hamburg−Eppendorf
Herta Flor: Heidelberg University
Vincent Frouin: Université Paris−Saclay
Hugh Garavan: University of Vermont
Philip A. Spechler: University of Vermont
Penny Gowland: University of Nottingham
Yvonne Grimmer: Heidelberg University
Andreas Heinz: Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
Bernd Ittermann: Physikalisch-Technische Bundesanstalt
Viola Kappel: Humboldt University
Jean-Luc Martinot: Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 Neuroimaging & Psychiatry, University Paris Saclay, University Paris Descartes; DIgiteo-Labs, Gif-sur-Yvette; and Maison de Solenn
Andreas Meyer-Lindenberg: Heidelberg University
Sabina Millenet: Heidelberg University
Frauke Nees: Heidelberg University
Betteke Noort: Humboldt University
Dimitri Papadopoulos Orfanos: Université Paris−Saclay
Marie-Laure Paillère Martinot: Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 Neuroimaging & Psychiatry, University Paris Saclay, University Paris Descartes; DIgiteo-Labs
Jani Penttilä: Psychosocial Services Adolescent Outpatient Clinic
Luise Poustka: University Medical Centre Göttingen
Erin Burke Quinlan: King’s College London
Michael N. Smolka: Technische Universität Dresden
Argyris Stringaris: King’s College London
Maren Struve: Technische Universität Dresden
Ilya M. Veer: Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
Henrik Walter: Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
Robert Whelan: Trinity College Dublin
Ole A. Andreassen: Oslo University Hospital
Ingrid Agartz: University of Oslo
Hervé Lemaitre: Institut National de la Santé et de la Recherche Médicale, UMR 992 INSERM, CEA, Faculté de médecine, Université Paris-Sud, Université Paris-Saclay, NeuroSpin
Edward D. Barker: King’s College London
John Ashburner: University College London
Elisabeth Binder: Max Planck Institute of Psychiatry
Jan Buitelaar: Radboud University Nijmegen
Andre Marquand: Radboud University Nijmegen
Trevor W. Robbins: University of Cambridge
Gunter Schumann: King’s College London

Nature Human Behaviour, 2019, vol. 3, issue 12, 1306-1318

Abstract: Abstract Most psychopathological disorders develop in adolescence. The biological basis for this development is poorly understood. To enhance diagnostic characterization and develop improved targeted interventions, it is critical to identify behavioural symptom groups that share neural substrates. We ran analyses to find relationships between behavioural symptoms and neuroimaging measures of brain structure and function in adolescence. We found two symptom groups, consisting of anxiety/depression and executive dysfunction symptoms, respectively, that correlated with distinct sets of brain regions and inter-regional connections, measured by structural and functional neuroimaging modalities. We found that the neural correlates of these symptom groups were present before behavioural symptoms had developed. These neural correlates showed case–control differences in corresponding psychiatric disorders, depression and attention deficit hyperactivity disorder in independent clinical samples. By characterizing behavioural symptom groups based on shared neural mechanisms, our results provide a framework for developing a classification system for psychiatric illness that is based on quantitative neurobehavioural measures.

Date: 2019
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DOI: 10.1038/s41562-019-0738-8

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