Spectrotemporal modulation provides a unifying framework for auditory cortical asymmetries

Adeen Flinker (), Werner K. Doyle, Ashesh D. Mehta, Orrin Devinsky and David Poeppel
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Adeen Flinker: New York University
Werner K. Doyle: New York University School of Medicine
Ashesh D. Mehta: Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
Orrin Devinsky: New York University School of Medicine
David Poeppel: New York University

Nature Human Behaviour, 2019, vol. 3, issue 4, 393-405

Abstract: Abstract The principles underlying functional asymmetries in cortex remain debated. For example, it is accepted that speech is processed bilaterally in auditory cortex, but a left hemisphere dominance emerges when the input is interpreted linguistically. The mechanisms, however, are contested, such as what sound features or processing principles underlie laterality. Recent findings across species (humans, canines and bats) provide converging evidence that spectrotemporal sound features drive asymmetrical responses. Typically, accounts invoke models wherein the hemispheres differ in time–frequency resolution or integration window size. We develop a framework that builds on and unifies prevailing models, using spectrotemporal modulation space. Using signal processing techniques motivated by neural responses, we test this approach, employing behavioural and neurophysiological measures. We show how psychophysical judgements align with spectrotemporal modulations and then characterize the neural sensitivities to temporal and spectral modulations. We demonstrate differential contributions from both hemispheres, with a left lateralization for temporal modulations and a weaker right lateralization for spectral modulations. We argue that representations in the modulation domain provide a more mechanistic basis to account for lateralization in auditory cortex.

Date: 2019
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DOI: 10.1038/s41562-019-0548-z

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