New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders

Evangelos Evangelou, He Gao, Congying Chu, Georgios Ntritsos, Paul Blakeley, Andrew R. Butts, Raha Pazoki, Hideaki Suzuki, Fotios Koskeridis, Andrianos M. Yiorkas, Ibrahim Karaman, Joshua Elliott, Qiang Luo, Stefanie Aeschbacher, Traci M. Bartz, Sebastian E. Baumeister, Peter S. Braund, Michael R. Brown, Jennifer A. Brody, Toni-Kim Clarke, Niki Dimou, Jessica D. Faul, Georg Homuth, Anne U. Jackson, Katherine A. Kentistou, Peter K. Joshi, Rozenn N. Lemaitre, Penelope A. Lind, Leo-Pekka Lyytikäinen, Massimo Mangino, Yuri Milaneschi, Christopher P. Nelson, Ilja M. Nolte, Mia-Maria Perälä, Ozren Polasek, David Porteous, Scott M. Ratliff, Jennifer A. Smith, Alena Stančáková, Alexander Teumer, Samuli Tuominen, Sébastien Thériault, Jagadish Vangipurapu, John B. Whitfield, Alexis Wood, Jie Yao, Bing Yu, Wei Zhao, Dan E. Arking, Juha Auvinen, Chunyu Liu, Minna Männikkö, Lorenz Risch, Jerome I. Rotter, Harold Snieder, Juha Veijola, Alexandra I. Blakemore, Michael Boehnke, Harry Campbell, David Conen, Johan G. Eriksson, Hans J. Grabe, Xiuqing Guo, Pim Harst, Catharina A. Hartman, Caroline Hayward, Andrew C. Heath, Marjo-Riitta Jarvelin, Mika Kähönen, Sharon L. R. Kardia, Michael Kühne, Johanna Kuusisto, Markku Laakso, Jari Lahti, Terho Lehtimäki, Andrew M. McIntosh, Karen L. Mohlke, Alanna C. Morrison, Nicholas G. Martin, Albertine J. Oldehinkel, Brenda W. J. H. Penninx, Bruce M. Psaty, Olli T. Raitakari, Igor Rudan, Nilesh J. Samani, Laura J. Scott, Tim D. Spector, Niek Verweij, David R. Weir, James F. Wilson, Daniel Levy, Ioanna Tzoulaki, Jimmy D. Bell, Paul M. Matthews, Adrian Rothenfluh, Sylvane Desrivières, Gunter Schumann () and Paul Elliott ()
Additional contact information
Evangelos Evangelou: Imperial College London
He Gao: Imperial College London
Congying Chu: King’s College London
Georgios Ntritsos: University of Ioannina Medical School
Paul Blakeley: Imperial College London
Andrew R. Butts: University of Utah
Raha Pazoki: Imperial College London
Hideaki Suzuki: Imperial College London
Fotios Koskeridis: University of Ioannina Medical School
Andrianos M. Yiorkas: Brunel University London
Ibrahim Karaman: Imperial College London
Joshua Elliott: Imperial College London
Qiang Luo: Fudan University
Stefanie Aeschbacher: University Hospital Basel
Traci M. Bartz: University of Washington
Sebastian E. Baumeister: University Medicine Greifswald
Peter S. Braund: University of Leicester, Cardiovascular Research Centre, Glenfield Hospital
Michael R. Brown: The University of Texas Health Science Center at Houston
Jennifer A. Brody: University of Washington
Toni-Kim Clarke: University of Edinburgh
Niki Dimou: University of Ioannina Medical School
Jessica D. Faul: University of Michigan
Georg Homuth: University Medicine Greifswald
Anne U. Jackson: University of Michigan
Katherine A. Kentistou: University of Edinburgh
Peter K. Joshi: University of Edinburgh
Rozenn N. Lemaitre: University of Washington
Penelope A. Lind: QIMR Berghofer Medical Research Institute
Leo-Pekka Lyytikäinen: Fimlab Laboratories
Massimo Mangino: King’s College London
Yuri Milaneschi: Amsterdam University Medical Center
Christopher P. Nelson: University of Leicester, Cardiovascular Research Centre, Glenfield Hospital
Ilja M. Nolte: University Medical Center Groningen, University of Groningen
Mia-Maria Perälä: Folkhälsan Research Center
Ozren Polasek: University of Split
David Porteous: University of Edinburgh
Scott M. Ratliff: University of Michigan
Jennifer A. Smith: University of Michigan
Alena Stančáková: University of Eastern Finland
Alexander Teumer: University Medicine Greifswald
Samuli Tuominen: University of Helsinki
Sébastien Thériault: McMaster University
Jagadish Vangipurapu: University of Eastern Finland
John B. Whitfield: QIMR Berghofer Medical Research Institute
Alexis Wood: Baylor College of Medicine
Jie Yao: Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
Bing Yu: The University of Texas Health Science Center at Houston
Wei Zhao: University of Michigan
Dan E. Arking: Johns Hopkins University School of Medicine
Juha Auvinen: University of Oulu
Chunyu Liu: Boston University School of Public Health
Minna Männikkö: University of Oulu
Lorenz Risch: University Hospital, University of Bern
Jerome I. Rotter: Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
Harold Snieder: University Medical Center Groningen, University of Groningen
Juha Veijola: University of Oulu
Alexandra I. Blakemore: Brunel University London
Michael Boehnke: University of Michigan
Harry Campbell: University of Edinburgh
David Conen: McMaster University
Johan G. Eriksson: University of Helsinki
Hans J. Grabe: University Medicine Greifswald
Xiuqing Guo: Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
Pim Harst: University Medical Center Groningen, University of Groningen
Catharina A. Hartman: University Medical Center Groningen, University of Groningen
Caroline Hayward: University of Edinburgh, Western General Hospital
Andrew C. Heath: Washington University in St Louis
Marjo-Riitta Jarvelin: Imperial College London
Mika Kähönen: Tampere University Hospital
Sharon L. R. Kardia: University of Michigan
Michael Kühne: University Hospital Basel
Johanna Kuusisto: University of Eastern Finland and Kuopio University Hospital
Markku Laakso: University of Eastern Finland and Kuopio University Hospital
Jari Lahti: University of Helsinki
Terho Lehtimäki: Fimlab Laboratories
Andrew M. McIntosh: University of Edinburgh
Karen L. Mohlke: University of North Carolina
Alanna C. Morrison: The University of Texas Health Science Center at Houston
Nicholas G. Martin: QIMR Berghofer Medical Research Institute
Albertine J. Oldehinkel: University Medical Center Groningen, University of Groningen
Brenda W. J. H. Penninx: Amsterdam University Medical Center
Bruce M. Psaty: University of Washington
Olli T. Raitakari: Turku University Hospital
Igor Rudan: University of Edinburgh
Nilesh J. Samani: University of Leicester, Cardiovascular Research Centre, Glenfield Hospital
Laura J. Scott: University of Michigan
Tim D. Spector: King’s College London
Niek Verweij: University Medical Center Groningen, University of Groningen
David R. Weir: University of Michigan
James F. Wilson: University of Edinburgh
Daniel Levy: Framingham Heart Study
Ioanna Tzoulaki: Imperial College London
Jimmy D. Bell: University of Westminster
Paul M. Matthews: Imperial College London
Adrian Rothenfluh: University of Utah
Sylvane Desrivières: King’s College London
Gunter Schumann: King’s College London
Paul Elliott: Imperial College London

Nature Human Behaviour, 2019, vol. 3, issue 9, 950-961

Abstract: Abstract Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. Here we conducted a meta-analysis of genome-wide association studies of alcohol consumption (g d−1) from the UK Biobank, the Alcohol Genome-Wide Consortium and the Cohorts for Heart and Aging Research in Genomic Epidemiology Plus consortia, collecting data from 480,842 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 new common loci and investigated their potential functional importance using magnetic resonance imaging data and gene expression studies. We identify genetic pathways associated with alcohol consumption and suggest genetic mechanisms that are shared with neuropsychiatric disorders such as schizophrenia.

Date: 2019
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DOI: 10.1038/s41562-019-0653-z

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