Shared vulnerability for connectome alterations across psychiatric and neurological brain disorders

Siemon C. Lange, Lianne H. Scholtens, Leonard H. Berg, Marco P. Boks, Marco Bozzali, Wiepke Cahn, Udo Dannlowski, Sarah Durston, Elbert Geuze, Neeltje E. M. Haren, Manon H. J. Hillegers, Kathrin Koch, María Ángeles Jurado, Matteo Mancini, Idoia Marqués-Iturria, Susanne Meinert, Roel A. Ophoff, Tim J. Reess, Jonathan Repple, René S. Kahn and Martijn P. Heuvel ()
Additional contact information
Siemon C. Lange: Vrije Universiteit Amsterdam, Amsterdam Neuroscience
Lianne H. Scholtens: Vrije Universiteit Amsterdam, Amsterdam Neuroscience
Leonard H. Berg: University Medical Center Utrecht
Marco P. Boks: University Medical Center Utrecht
Marco Bozzali: University of Sussex
Wiepke Cahn: University Medical Center Utrecht
Udo Dannlowski: University of Muenster
Sarah Durston: University Medical Center Utrecht
Elbert Geuze: University Medical Center Utrecht
Neeltje E. M. Haren: University Medical Center Utrecht
Manon H. J. Hillegers: University Medical Center Utrecht
Kathrin Koch: Technische Universität München
María Ángeles Jurado: Universitat de Barcelona
Matteo Mancini: Brighton and Sussex Medical School
Idoia Marqués-Iturria: Universitat de Barcelona
Susanne Meinert: University of Muenster
Roel A. Ophoff: University of California Los Angeles
Tim J. Reess: Technische Universität München
Jonathan Repple: University of Muenster
René S. Kahn: Icahn School of Medicine at Mount Sinai
Martijn P. Heuvel: Vrije Universiteit Amsterdam, Amsterdam Neuroscience

Nature Human Behaviour, 2019, vol. 3, issue 9, 988-998

Abstract: Abstract Macroscale white matter pathways are the infrastructure for large-scale communication in the human brain and a prerequisite for healthy brain function. Disruptions in the brain’s connectivity architecture play an important role in many psychiatric and neurological brain disorders. Here we show that connections important for global communication and network integration are particularly vulnerable to brain alterations across multiple brain disorders. We report on a cross-disorder connectome study comprising in total 1,033 patients and 1,154 matched controls across 8 psychiatric and 4 neurological disorders. We extracted disorder connectome fingerprints for each of these 12 disorders and combined them into a ‘cross-disorder disconnectivity involvement map’ describing the level of cross-disorder involvement of each white matter pathway of the human brain network. Network analysis revealed connections central to global network communication and integration to display high disturbance across disorders, suggesting a general cross-disorder involvement and the importance of these pathways in normal function.

Date: 2019
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41562-019-0659-6 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nathum:v:3:y:2019:i:9:d:10.1038_s41562-019-0659-6

Ordering information: This journal article can be ordered from
https://www.nature.com/nathumbehav/

DOI: 10.1038/s41562-019-0659-6

Access Statistics for this article

Nature Human Behaviour is currently edited by Stavroula Kousta

More articles in Nature Human Behaviour from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().