GWAS of 165,084 Japanese individuals identified nine loci associated with dietary habits

Nana Matoba, Masato Akiyama, Kazuyoshi Ishigaki, Masahiro Kanai, Atsushi Takahashi, Yukihide Momozawa, Shiro Ikegawa, Masashi Ikeda, Nakao Iwata, Makoto Hirata, Koichi Matsuda, Yoshinori Murakami, Michiaki Kubo, Yoichiro Kamatani () and Yukinori Okada ()
Additional contact information
Nana Matoba: Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
Masato Akiyama: Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
Kazuyoshi Ishigaki: Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
Masahiro Kanai: Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
Atsushi Takahashi: Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
Yukihide Momozawa: Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences
Shiro Ikegawa: Laboratory for Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences
Masashi Ikeda: Fujita Health University School of Medicine
Nakao Iwata: Fujita Health University School of Medicine
Makoto Hirata: The University of Tokyo
Koichi Matsuda: The University of Tokyo
Yoshinori Murakami: The University of Tokyo
Michiaki Kubo: RIKEN Center for Integrative Medical Sciences
Yoichiro Kamatani: Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
Yukinori Okada: Osaka University Graduate School of Medicine

Nature Human Behaviour, 2020, vol. 4, issue 3, 308-316

Abstract: Abstract Dietary habits are important factors in our lifestyle, and confer both susceptibility to and protection from a variety of human diseases. We performed genome-wide association studies for 13 dietary habits including consumption of alcohol (ever versus never drinkers and drinks per week), beverages (coffee, green tea and milk) and foods (yoghurt, cheese, natto, tofu, fish, small whole fish, vegetables and meat) in Japanese individuals (n = 58,610–165,084) collected by BioBank Japan, the nationwide hospital-based genome cohort. Significant associations were found in nine genetic loci (MCL1-ENSA, GCKR, AGR3-AHR, ADH1B, ALDH1B1, ALDH1A1, ALDH2, CYP1A2-CSK and ADORA2A-AS1) for 13 dietary traits (P

Date: 2020
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DOI: 10.1038/s41562-019-0805-1

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