Neurobehavioural characterisation and stratification of reinforcement-related behaviour

Tianye Jia (), Alex Ing, Erin Burke Quinlan, Nicole Tay, Qiang Luo, Biondo Francesca, Tobias Banaschewski, Gareth J. Barker, Arun L. W. Bokde, Uli Bromberg, Christian Büchel, Sylvane Desrivières, Jianfeng Feng, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Juliane H. Fröhner, Michael N. Smolka, Henrik Walter, Robert Whelan and Gunter Schumann ()
Additional contact information
Tianye Jia: Fudan University
Alex Ing: Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, SGDP Centre, King’s College London
Erin Burke Quinlan: Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, SGDP Centre, King’s College London
Nicole Tay: Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, SGDP Centre, King’s College London
Qiang Luo: Fudan University
Biondo Francesca: Fudan University
Tobias Banaschewski: Heidelberg University
Gareth J. Barker: Psychology & Neuroscience, King’s College London
Arun L. W. Bokde: Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin
Uli Bromberg: University Medical Centre Hamburg-Eppendorf
Christian Büchel: University Medical Centre Hamburg-Eppendorf
Sylvane Desrivières: Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, SGDP Centre, King’s College London
Jianfeng Feng: Fudan University
Herta Flor: Heidelberg University
Antoine Grigis: NeuroSpin, CEA, Université Paris-Saclay
Hugh Garavan: University of Vermont, Burlington
Penny Gowland: University of Nottingham, University Park
Andreas Heinz: Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
Bernd Ittermann: Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin
Jean-Luc Martinot: University Paris Saclay, University Paris Descartes; DIgiteo-Labs
Marie-Laure Paillère Martinot: University Paris Saclay, University Paris Descartes; DIgiteo-Labs
Frauke Nees: Heidelberg University
Dimitri Papadopoulos Orfanos: NeuroSpin, CEA, Université Paris-Saclay
Tomáš Paus: University of Toronto
Luise Poustka: University Medical Centre Göttingen
Juliane H. Fröhner: Technische Universität Dresden
Michael N. Smolka: Technische Universität Dresden
Henrik Walter: Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
Robert Whelan: Trinity College Dublin
Gunter Schumann: Fudan University

Nature Human Behaviour, 2020, vol. 4, issue 5, 544-558

Abstract: Abstract Reinforcement-related cognitive processes, such as reward processing, inhibitory control and social–emotional regulation are critical components of externalising and internalising behaviours. It is unclear to what extent the deficit in each of these processes contributes to individual behavioural symptoms, how their neural substrates give rise to distinct behavioural outcomes and whether neural activation profiles across different reinforcement-related processes might differentiate individual behaviours. We created a statistical framework that enabled us to directly compare functional brain activation during reward anticipation, motor inhibition and viewing emotional faces in the European IMAGEN cohort of 2,000 14-year-old adolescents. We observe significant correlations and modulation of reward anticipation and motor inhibition networks in hyperactivity, impulsivity, inattentive behaviour and conduct symptoms, and we describe neural signatures across cognitive tasks that differentiate these behaviours. We thus characterise shared and distinct functional brain activation patterns underling different externalising symptoms and identify neural stratification markers, while accounting for clinically observed comorbidity.

Date: 2020
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DOI: 10.1038/s41562-020-0846-5

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