Brain stimulation and brain lesions converge on common causal circuits in neuropsychiatric disease

Shan H. Siddiqi (), Frederic L. W. V. J. Schaper, Andreas Horn, Joey Hsu, Jaya L. Padmanabhan, Amy Brodtmann, Robin F. H. Cash, Maurizio Corbetta, Ki Sueng Choi, Darin D. Dougherty, Natalia Egorova, Paul B. Fitzgerald, Mark S. George, Sophia A. Gozzi, Frederike Irmen, Andrea A. Kuhn, Kevin A. Johnson, Andrew M. Naidech, Alvaro Pascual-Leone, Thanh G. Phan, Rob P. W. Rouhl, Stephan F. Taylor, Joel L. Voss, Andrew Zalesky, Jordan H. Grafman, Helen S. Mayberg and Michael D. Fox
Additional contact information
Shan H. Siddiqi: Brigham and Women’s Hospital
Frederic L. W. V. J. Schaper: Brigham and Women’s Hospital
Andreas Horn: Brigham and Women’s Hospital
Joey Hsu: University of Pittsburgh School of Medicine
Jaya L. Padmanabhan: Brigham and Women’s Hospital
Amy Brodtmann: The University of Melbourne
Robin F. H. Cash: The University of Melbourne
Maurizio Corbetta: University of Padova
Ki Sueng Choi: Icahn School of Medicine at Mount Sinai
Darin D. Dougherty: Harvard Medical School
Natalia Egorova: University of Melbourne
Paul B. Fitzgerald: Epworth Healthcare and Monash University Department of Psychiatry
Mark S. George: Medical University of South Carolina
Sophia A. Gozzi: Monash University
Frederike Irmen: Humboldt-Universität zu Berlin and Berlin Institute of Health
Andrea A. Kuhn: Charité University Medicine Berlin
Kevin A. Johnson: Florida State University
Andrew M. Naidech: Northwestern University
Alvaro Pascual-Leone: Harvard Medical School
Thanh G. Phan: Monash University
Rob P. W. Rouhl: Maastricht University Medical Center
Stephan F. Taylor: University of Michigan School of Medicine
Joel L. Voss: Northwestern University
Andrew Zalesky: The University of Melbourne
Jordan H. Grafman: Northwestern University
Helen S. Mayberg: Icahn School of Medicine at Mount Sinai
Michael D. Fox: Brigham and Women’s Hospital

Nature Human Behaviour, 2021, vol. 5, issue 12, 1707-1716

Abstract: Abstract Damage to specific brain circuits can cause specific neuropsychiatric symptoms. Therapeutic stimulation to these same circuits may modulate these symptoms. To determine whether these circuits converge, we studied depression severity after brain lesions (n = 461, five datasets), transcranial magnetic stimulation (n = 151, four datasets) and deep brain stimulation (n = 101, five datasets). Lesions and stimulation sites most associated with depression severity were connected to a similar brain circuit across all 14 datasets (P

Date: 2021
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DOI: 10.1038/s41562-021-01161-1

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