Genome-wide association study identifies 48 common genetic variants associated with handedness

Gabriel Cuellar-Partida, Joyce Y. Tung, Nicholas Eriksson, Eva Albrecht, Fazil Aliev, Ole A. Andreassen, Inês Barroso, Jacques S. Beckmann, Marco P. Boks, Dorret I. Boomsma, Heather A. Boyd, Monique M. B. Breteler, Harry Campbell, Daniel I. Chasman, Lynn F. Cherkas, Gail Davies, Eco J. C. Geus, Ian J. Deary, Panos Deloukas, Danielle M. Dick, David L. Duffy, Johan G. Eriksson, Tõnu Esko, Bjarke Feenstra, Frank Geller, Christian Gieger, Ina Giegling, Scott D. Gordon, Jiali Han, Thomas F. Hansen, Annette M. Hartmann, Caroline Hayward, Kauko Heikkilä, Andrew A. Hicks, Joel N. Hirschhorn, Jouke-Jan Hottenga, Jennifer E. Huffman, Liang-Dar Hwang, M. Arfan Ikram, Jaakko Kaprio, John P. Kemp, Kay-Tee Khaw, Norman Klopp, Bettina Konte, Zoltan Kutalik, Jari Lahti, Xin Li, Ruth J. F. Loos, Michelle Luciano, Sigurdur H. Magnusson, Massimo Mangino, Pedro Marques-Vidal, Nicholas G. Martin, Wendy L. McArdle, Mark I. McCarthy, Carolina Medina-Gomez, Mads Melbye, Scott A. Melville, Andres Metspalu, Lili Milani, Vincent Mooser, Mari Nelis, Dale R. Nyholt, Kevin S. O’Connell, Roel A. Ophoff, Cameron Palmer, Aarno Palotie, Teemu Palviainen, Guillaume Pare, Lavinia Paternoster, Leena Peltonen, Brenda W. J. H. Penninx, Ozren Polasek, Peter P. Pramstaller, Inga Prokopenko, Katri Raikkonen, Samuli Ripatti, Fernando Rivadeneira, Igor Rudan, Dan Rujescu, Johannes H. Smit, George Davey Smith, Jordan W. Smoller, Nicole Soranzo, Tim D. Spector, Beate St Pourcain, John M. Starr, Hreinn Stefánsson, Stacy Steinberg, Maris Teder-Laving, Gudmar Thorleifsson, Kári Stefánsson, Nicholas J. Timpson, André G. Uitterlinden, Cornelia M. Duijn, Frank J. A. Rooij, Jaqueline M. Vink, Peter Vollenweider, Eero Vuoksimaa, Gérard Waeber, Nicholas J. Wareham, Nicole Warrington, Dawn Waterworth, Thomas Werge, H.-Erich Wichmann, Elisabeth Widen, Gonneke Willemsen, Alan F. Wright, Margaret J. Wright, Mousheng Xu, Jing Hua Zhao, Peter Kraft, David A. Hinds, Cecilia M. Lindgren, Reedik Mägi, Benjamin M. Neale, David M. Evans () and Sarah E. Medland ()
Additional contact information
Gabriel Cuellar-Partida: The University of Queensland
Joyce Y. Tung: 23andMe, Inc.
Nicholas Eriksson: 23andMe, Inc.
Eva Albrecht: Helmholtz Zentrum München—German Research Center for Environmental Health
Fazil Aliev: Virginia Commonwealth University
Ole A. Andreassen: University of Oslo
Inês Barroso: Wellcome Sanger Institute
Jacques S. Beckmann: Centre Hospitalier Universitaire Vaudois and University of Lausanne
Marco P. Boks: University Utrecht
Dorret I. Boomsma: Vrije Universiteit
Heather A. Boyd: Statens Serum Institut
Monique M. B. Breteler: German Center for Neurodegenerative Diseases (DZNE)
Harry Campbell: University of Edinburgh
Daniel I. Chasman: Brigham and Women’s Hospital
Lynn F. Cherkas: King’s College London
Gail Davies: University of Edinburgh
Eco J. C. Geus: Vrije Universiteit
Ian J. Deary: University of Edinburgh
Panos Deloukas: Queen Mary University of London
Danielle M. Dick: Virginia Commonwealth University
David L. Duffy: QIMR Berghofer Medical Research Institute
Johan G. Eriksson: University of Helsinki and Helsinki University Hospital
Tõnu Esko: University of Tartu
Bjarke Feenstra: Statens Serum Institut
Frank Geller: Statens Serum Institut
Christian Gieger: Institute of Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health
Ina Giegling: Martin-Luther-University Halle-Wittenberg
Scott D. Gordon: QIMR Berghofer Medical Research Institute
Jiali Han: Indiana University
Thomas F. Hansen: Mental Health Services of Copenhagen
Annette M. Hartmann: Martin-Luther-University Halle-Wittenberg
Caroline Hayward: University of Edinburgh
Kauko Heikkilä: University of Helsinki
Andrew A. Hicks: Eurac Research
Joel N. Hirschhorn: Boston Children’s Hospital
Jouke-Jan Hottenga: Vrije Universiteit
Jennifer E. Huffman: University of Edinburgh
Liang-Dar Hwang: The University of Queensland
M. Arfan Ikram: University Medical Center
Jaakko Kaprio: University of Helsinki
John P. Kemp: The University of Queensland
Kay-Tee Khaw: University of Cambridge
Norman Klopp: Hannover Medical School
Bettina Konte: Martin-Luther-University Halle-Wittenberg
Zoltan Kutalik: University of Lausanne
Jari Lahti: University of Helsinki
Xin Li: Indiana University
Ruth J. F. Loos: University of Cambridge
Michelle Luciano: University of Edinburgh
Sigurdur H. Magnusson: deCODE Genetics
Massimo Mangino: King’s College London
Pedro Marques-Vidal: Lausanne University Hospital and University of Lausanne
Nicholas G. Martin: QIMR Berghofer Medical Research Institute
Wendy L. McArdle: University of Bristol
Mark I. McCarthy: University of Oxford
Carolina Medina-Gomez: University Medical Center
Mads Melbye: Statens Serum Institut
Scott A. Melville: Eurac Research
Andres Metspalu: University of Tartu
Lili Milani: University of Tartu
Vincent Mooser: Lausanne University Hospital and University of Lausanne
Mari Nelis: University of Tartu
Dale R. Nyholt: QIMR Berghofer Medical Research Institute
Kevin S. O’Connell: University of Oslo
Roel A. Ophoff: University California Los Angeles
Cameron Palmer: Columbia University
Aarno Palotie: University of Helsinki
Teemu Palviainen: University of Helsinki
Guillaume Pare: McMaster University
Lavinia Paternoster: University of Bristol
Leena Peltonen: University of Helsinki
Brenda W. J. H. Penninx: Amsterdam University Medical Centers
Ozren Polasek: University of Split School of Medicine
Peter P. Pramstaller: Eurac Research
Inga Prokopenko: University of Surrey
Katri Raikkonen: University of Helsinki
Samuli Ripatti: University of Helsinki
Fernando Rivadeneira: University Medical Center
Igor Rudan: University of Edinburgh
Dan Rujescu: Martin-Luther-University Halle-Wittenberg
Johannes H. Smit: Amsterdam University Medical Centers
George Davey Smith: University of Bristol
Jordan W. Smoller: Massachusetts General Hospital
Nicole Soranzo: Wellcome Sanger Institute
Tim D. Spector: King’s College London
Beate St Pourcain: University of Bristol
John M. Starr: University of Edinburgh
Hreinn Stefánsson: deCODE Genetics
Stacy Steinberg: deCODE Genetics
Maris Teder-Laving: University of Tartu
Gudmar Thorleifsson: deCODE Genetics
Kári Stefánsson: deCODE Genetics
Nicholas J. Timpson: University of Bristol
André G. Uitterlinden: University Medical Center
Cornelia M. Duijn: University Medical Center
Frank J. A. Rooij: University Medical Center
Jaqueline M. Vink: Vrije Universiteit
Peter Vollenweider: Lausanne University Hospital and University of Lausanne
Eero Vuoksimaa: University of Helsinki
Gérard Waeber: Lausanne University Hospital and University of Lausanne
Nicholas J. Wareham: University of Cambridge
Nicole Warrington: The University of Queensland
Dawn Waterworth: GlaxoSmithKline
Thomas Werge: Mental Health Services of Copenhagen
H.-Erich Wichmann: Helmholtz Center
Elisabeth Widen: University of Helsinki
Gonneke Willemsen: Vrije Universiteit
Alan F. Wright: University of Edinburgh
Margaret J. Wright: The University of Queensland
Mousheng Xu: Harvard Medical School
Jing Hua Zhao: University of Cambridge
Peter Kraft: Harvard Medical School
David A. Hinds: 23andMe, Inc.
Cecilia M. Lindgren: University of Oxford
Reedik Mägi: University of Tartu
Benjamin M. Neale: Broad Institute of MIT and Harvard
David M. Evans: The University of Queensland
Sarah E. Medland: The University of Queensland

Nature Human Behaviour, 2021, vol. 5, issue 1, 59-70

Abstract: Abstract Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysis of handedness (N = 1,766,671). We found 41 loci associated (P

Date: 2021
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DOI: 10.1038/s41562-020-00956-y

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