Structural and functional asymmetry of the neonatal cerebral cortex

Logan Z. J. Williams (), Sean P. Fitzgibbon, Jelena Bozek, Anderson M. Winkler, Ralica Dimitrova, Tanya Poppe, Andreas Schuh, Antonios Makropoulos, John Cupitt, Jonathan O’Muircheartaigh, Eugene P. Duff, Lucilio Cordero-Grande, Anthony N. Price, Joseph V. Hajnal, Daniel Rueckert, Stephen M. Smith, A. David Edwards and Emma C. Robinson ()
Additional contact information
Logan Z. J. Williams: King’s College London
Sean P. Fitzgibbon: University of Oxford, John Radcliffe Hospital
Jelena Bozek: University of Zagreb
Anderson M. Winkler: National Institute of Mental Health, National Institutes of Health
Ralica Dimitrova: King’s College London
Tanya Poppe: King’s College London
Andreas Schuh: Imperial College London
Antonios Makropoulos: King’s College London
John Cupitt: Imperial College London
Jonathan O’Muircheartaigh: King’s College London
Eugene P. Duff: University of Oxford, John Radcliffe Hospital
Lucilio Cordero-Grande: King’s College London
Anthony N. Price: King’s College London
Joseph V. Hajnal: King’s College London
Daniel Rueckert: Imperial College London
Stephen M. Smith: University of Oxford, John Radcliffe Hospital
A. David Edwards: King’s College London
Emma C. Robinson: King’s College London

Nature Human Behaviour, 2023, vol. 7, issue 6, 942-955

Abstract: Abstract Features of brain asymmetry have been implicated in a broad range of cognitive processes; however, their origins are still poorly understood. Here we investigated cortical asymmetries in 442 healthy term-born neonates using structural and functional magnetic resonance images from the Developing Human Connectome Project. Our results demonstrate that the neonatal cortex is markedly asymmetric in both structure and function. Cortical asymmetries observed in the term cohort were contextualized in two ways: by comparing them against cortical asymmetries observed in 103 preterm neonates scanned at term-equivalent age, and by comparing structural asymmetries against those observed in 1,110 healthy young adults from the Human Connectome Project. While associations with preterm birth and biological sex were minimal, significant differences exist between birth and adulthood.

Date: 2023
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DOI: 10.1038/s41562-023-01542-8

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