A systematic review and meta-analysis of 90 cohort studies of social isolation, loneliness and mortality

Fan Wang, Yu Gao, Zhen Han, Yue Yu, Zhiping Long, Xianchen Jiang, Yi Wu, Bing Pei, Yukun Cao, Jingyu Ye, Maoqing Wang () and Yashuang Zhao ()
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Fan Wang: Harbin Medical University
Yu Gao: Harbin Medical University
Zhen Han: Harbin Medical University
Yue Yu: Harbin Medical University
Zhiping Long: Harbin Medical University
Xianchen Jiang: Quzhou Center for Disease Control and Prevention
Yi Wu: Harbin Medical University
Bing Pei: Harbin Medical University
Yukun Cao: Harbin Medical University
Jingyu Ye: Harbin Medical University
Maoqing Wang: Harbin Medical University
Yashuang Zhao: Harbin Medical University

Nature Human Behaviour, 2023, vol. 7, issue 8, 1307-1319

Abstract: Abstract The associations between social isolation, loneliness and the risk of mortality from all causes, cardiovascular disease (CVD) and cancer are controversial. We systematically reviewed prospective studies on the association between social isolation, loneliness and mortality outcomes in adults aged 18 years or older, as well as studies on these relationships in individuals with CVD or cancer, and conducted a meta-analysis. The study protocol was registered with PROSPERO (reg. no. CRD42022299959). A total of 90 prospective cohort studies including 2,205,199 individuals were included. Here we show that, in the general population, both social isolation and loneliness were significantly associated with an increased risk of all-cause mortality (pooled effect size for social isolation, 1.32; 95% confidence interval (CI), 1.26 to 1.39; P

Date: 2023
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DOI: 10.1038/s41562-023-01617-6

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