Binding of cortical functional modules by synchronous high-frequency oscillations

Jacob C. Garrett, Ilya A. Verzhbinsky, Erik Kaestner, Chad Carlson, Werner K. Doyle, Orrin Devinsky, Thomas Thesen and Eric Halgren ()
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Jacob C. Garrett: University of California, San Diego
Ilya A. Verzhbinsky: University of California, San Diego
Erik Kaestner: University of California, San Diego
Chad Carlson: Medical College of Wisconsin
Werner K. Doyle: New York University Langone School of Medicine
Orrin Devinsky: New York University Langone School of Medicine
Thomas Thesen: Dartmouth College
Eric Halgren: University of California, San Diego

Nature Human Behaviour, 2024, vol. 8, issue 10, 1988-2002

Abstract: Abstract Whether high-frequency phase-locked oscillations facilitate integration (‘binding’) of information across widespread cortical areas is controversial. Here we show with intracranial electroencephalography that cortico-cortical co-ripples (~100-ms-long ~90 Hz oscillations) increase during reading and semantic decisions, at the times and co-locations when and where binding should occur. Fusiform wordform areas co-ripple with virtually all language areas, maximally from 200 to 400 ms post-word-onset. Semantically specified target words evoke strong co-rippling between wordform, semantic, executive and response areas from 400 to 800 ms, with increased co-rippling between semantic, executive and response areas prior to correct responses. Co-ripples were phase-locked at zero lag over long distances (>12 cm), especially when many areas were co-rippling. General co-activation, indexed by non-oscillatory high gamma, was mainly confined to early latencies in fusiform and earlier visual areas, preceding co-ripples. These findings suggest that widespread synchronous co-ripples may assist the integration of multiple cortical areas for sustained periods during cognition.

Date: 2024
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DOI: 10.1038/s41562-024-01952-2

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