Theta phase precession supports memory formation and retrieval of naturalistic experience in humans

Jie Zheng, Mar Yebra, Andrea G. P. Schjetnan, Kramay Patel, Chaim N. Katz, Michael Kyzar, Clayton P. Mosher, Suneil K. Kalia, Jeffrey M. Chung, Chrystal M. Reed, Taufik A. Valiante, Adam N. Mamelak, Gabriel Kreiman () and Ueli Rutishauser ()
Additional contact information
Jie Zheng: Cedars-Sinai Medical Center
Mar Yebra: Cedars-Sinai Medical Center
Andrea G. P. Schjetnan: University of Toronto
Kramay Patel: University of Toronto
Chaim N. Katz: University of Toronto
Michael Kyzar: Cedars-Sinai Medical Center
Clayton P. Mosher: Cedars-Sinai Medical Center
Suneil K. Kalia: University of Toronto
Jeffrey M. Chung: Cedars-Sinai Medical Center
Chrystal M. Reed: Cedars-Sinai Medical Center
Taufik A. Valiante: University of Toronto
Adam N. Mamelak: Cedars-Sinai Medical Center
Gabriel Kreiman: Harvard Medical School
Ueli Rutishauser: Cedars-Sinai Medical Center

Nature Human Behaviour, 2024, vol. 8, issue 12, 2423-2436

Abstract: Abstract Associating different aspects of experience with discrete events is critical for human memory. A potential mechanism for linking memory components is phase precession, during which neurons fire progressively earlier in time relative to theta oscillations. However, no direct link between phase precession and memory has been established. Here we recorded single-neuron activity and local field potentials in the human medial temporal lobe while participants (n = 22) encoded and retrieved memories of movie clips. Bouts of theta and phase precession occurred following cognitive boundaries during movie watching and following stimulus onsets during memory retrieval. Phase precession was dynamic, with different neurons exhibiting precession in different task periods. Phase precession strength provided information about memory encoding and retrieval success that was complementary with firing rates. These data provide direct neural evidence for a functional role of phase precession in human episodic memory.

Date: 2024
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DOI: 10.1038/s41562-024-01983-9

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