Intracranial electroencephalography reveals effector-independent evidence accumulation dynamics in multiple human brain regions

Sabina Gherman (), Noah Markowitz, Gelana Tostaeva, Elizabeth Espinal, Ashesh D. Mehta, Redmond G. O’Connell, Simon P. Kelly and Stephan Bickel ()
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Sabina Gherman: Northwell Health
Noah Markowitz: Northwell Health
Gelana Tostaeva: Northwell Health
Elizabeth Espinal: Northwell Health
Ashesh D. Mehta: Northwell Health
Redmond G. O’Connell: Trinity College Dublin
Simon P. Kelly: University College Dublin
Stephan Bickel: Northwell Health

Nature Human Behaviour, 2024, vol. 8, issue 4, 758-770

Abstract: Abstract Neural representations of perceptual decision formation that are abstracted from specific motor requirements have previously been identified in humans using non-invasive electrophysiology; however, it is currently unclear where these originate in the brain. Here we capitalized on the high spatiotemporal precision of intracranial EEG to localize such abstract decision signals. Participants undergoing invasive electrophysiological monitoring for epilepsy were asked to judge the direction of random-dot stimuli and respond either with a speeded button press (N = 24), or vocally, after a randomized delay (N = 12). We found a widely distributed motor-independent network of regions where high-frequency activity exhibited key characteristics consistent with evidence accumulation, including a gradual buildup that was modulated by the strength of the sensory evidence, and an amplitude that predicted participants’ choice accuracy and response time. Our findings offer a new view on the brain networks governing human decision-making.

Date: 2024
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DOI: 10.1038/s41562-024-01824-9

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