The neuroanatomy of developmental language disorder: a systematic review and meta-analysis

Michael T. Ullman (), Gillian M. Clark, Mariel Y. Pullman, Jarrett T. Lovelett, Elizabeth I. Pierpont, Xiong Jiang and Peter E. Turkeltaub
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Michael T. Ullman: Georgetown University
Gillian M. Clark: Cognitive Neuroscience Unit, School of Psychology, Deakin University, Geelong
Mariel Y. Pullman: Georgetown University
Jarrett T. Lovelett: Georgetown University
Elizabeth I. Pierpont: University of Minnesota Medical Center
Xiong Jiang: Georgetown University
Peter E. Turkeltaub: Center for Brain Plasticity and Recovery, Georgetown University

Nature Human Behaviour, 2024, vol. 8, issue 5, 962-975

Abstract: Abstract Developmental language disorder (DLD) is a common neurodevelopmental disorder with adverse impacts that continue into adulthood. However, its neural bases remain unclear. Here we address this gap by systematically identifying and quantitatively synthesizing neuroanatomical studies of DLD using co-localization likelihood estimation, a recently developed neuroanatomical meta-analytic technique. Analyses of structural brain data (22 peer-reviewed papers, 577 participants) revealed highly consistent anomalies only in the basal ganglia (100% of participant groups in which this structure was examined, weighted by group sample sizes; 99.8% permutation-based likelihood the anomaly clustering was not due to chance). These anomalies were localized specifically to the anterior neostriatum (again 100% weighted proportion and 99.8% likelihood). As expected given the task dependence of activation, functional neuroimaging data (11 peer-reviewed papers, 414 participants) yielded less consistency, though anomalies again occurred primarily in the basal ganglia (79.0% and 95.1%). Multiple sensitivity analyses indicated that the patterns were robust. The meta-analyses elucidate the neuroanatomical signature of DLD, and implicate the basal ganglia in particular. The findings support the procedural circuit deficit hypothesis of DLD, have basic research and translational implications for the disorder, and advance our understanding of the neuroanatomy of language.

Date: 2024
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DOI: 10.1038/s41562-024-01843-6

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