A systematic review and meta-analysis of strategies to promote vaccination uptake

Sicong Liu (), Marta R. Durantini, Christopher Calabrese, Flor Sanchez and Dolores Albarracin ()
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Sicong Liu: South China Normal University
Marta R. Durantini: University of Pennsylvania
Christopher Calabrese: University of Pennsylvania
Flor Sanchez: Universidad Autónoma de Madrid
Dolores Albarracin: University of Pennsylvania

Nature Human Behaviour, 2024, vol. 8, issue 9, 1689-1705

Abstract: Abstract Although immunization can dramatically curb the mortality and morbidity associated with vaccine-preventable diseases, vaccination uptake remains suboptimal in many areas of the world. Here, in this meta-analysis, we analysed the results from 88 eligible randomized controlled trials testing interventions to increase vaccination uptake with 1,628,768 participants from 17 countries with variable development levels (for example, Human Development Index ranging from 0.485 to 0.955). We estimated the efficacy of seven intervention strategies including increasing access to vaccination, sending vaccination reminders, providing incentives, supplying information, correcting misinformation, promoting both active and passive motivation and teaching behavioural skills. We showed that the odds of vaccination were 1.5 (95% confidence interval, 1.27 to 1.77) times higher for intervention than control conditions. Among the intervention strategies, using incentives and increasing access were most promising in improving vaccination uptake, with the access strategy being particularly effective in countries with lower incomes and less access to healthcare.

Date: 2024
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DOI: 10.1038/s41562-024-01940-6

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