Nature

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2025, volume 639, articles 8053

Postdocs and PhD students hit hard by Trump’s crackdown on science pp. 13-14

Heidi Ledford and Humberto Basilio

What sparked the COVID pandemic? Mounting evidence points to raccoon dogs pp. 14-15

Smriti Mallapaty

Breast cancer is on the rise: data reveal drastic gap in survival rates pp. 16-16

Giorgia Guglielmi

US pulls back from gold-standard scientific climate panel pp. 17-17

Jeff Tollefson

How a junk-food splurge can change your brain activity pp. 17-18

Julian Nowogrodzki

NIH turmoil sparks anxiety over future of its global grants pp. 18-19

Smriti Mallapaty and Miryam Naddaf

‘Slime’ keeps the brain safe ― and could guard against ageing pp. 19-20

Heidi Ledford

Iconic ocean-current system is safe from climate collapse ― for now pp. 20-20

Humberto Basilio

Against the odds: 12 women who beat bias to succeed in science pp. 29-31

Georgina Ferry

Stories of people, past, present and future: Books in brief pp. 31-31

Andrew Robinson

Four ways to help beat health inequities in the face of USAID cuts pp. 35-37

Lynn Hendricks, Raeka Aiyar, Uma Palanisamy and Nyasha Phanisa Sithole

ChatGPT for students: learners find creative new uses for chatbots pp. 265-266

Amanda Heidt

Tracking gulls to prevent a bird flu pandemic pp. 268-268

Miles Lizak

2025, volume 638, articles 8052

Streamflow shifts with declining snowfall pp. E35-E37

Wouter R. Berghuijs and Kate Hale

Reply to: Streamflow shifts with declining snowfall pp. E38-E39

Juntai Han, Ziwei Liu and Yuting Yang

Causal claims, causal assumptions and protected area impact pp. E40-E41

Jonas Geldmann, Julia P. G. Jones, Hannah Wauchope and Paul J. Ferraro

Reply to: Causal claims, causal assumptions and protected area impact pp. E42-E44

Jedediah F. Brodie, Jayasilan Mohd-Azlan, Cheng Chen, Oliver R. Wearn, Mairin C. M. Deith, James G. C. Ball, Eleanor M. Slade, David F. R. P. Burslem, Shu Woan Teoh, Peter J. Williams, An Nguyen, Jonathan H. Moore, Scott J. Goetz, Patrick Burns, Patrick Jantz, Christopher R. Hakkenberg, Zaneta Kaszta, Sam Cushman, David Coomes, Olga E. Helmy, Glen Reynolds, Jon Paul Rodríguez, Walter Jetz and Matthew Scott Luskin

Author Correction: GZMK-expressing CD8+ T cells promote recurrent airway inflammatory diseases pp. E45-E45

Feng Lan, Jizhou Li, Wenxuan Miao, Fei Sun, Su Duan, Yabing Song, Jiacheng Yao, Xiangdong Wang, Chengshuo Wang, Xin Liu, Jianbin Wang, Luo Zhang and Hai Qi

Author Correction: Virus-induced senescence is a driver and therapeutic target in COVID-19 pp. E46-E46

Soyoung Lee, Yong Yu, Jakob Trimpert, Fahad Benthani, Mario Mairhofer, Paulina Richter-Pechanska, Emanuel Wyler, Dimitri Belenki, Sabine Kaltenbrunner, Maria Pammer, Lea Kausche, Theresa C. Firsching, Kristina Dietert, Michael Schotsaert, Carles Martínez-Romero, Gagandeep Singh, Séverine Kunz, Daniela Niemeyer, Riad Ghanem, Helmut J. F. Salzer, Christian Paar, Michael Mülleder, Melissa Uccellini, Edward G. Michaelis, Amjad Khan, Andrea Lau, Martin Schönlein, Anna Habringer, Josef Tomasits, Julia M. Adler, Susanne Kimeswenger, Achim D. Gruber, Wolfram Hoetzenecker, Herta Steinkellner, Bettina Purfürst, Reinhard Motz, Francesco Di Pierro, Bernd Lamprecht, Nikolaus Osterrieder, Markus Landthaler, Christian Drosten, Adolfo García-Sastre, Rupert Langer, Markus Ralser, Roland Eils, Maurice Reimann, Dorothy N. Y. Fan and Clemens A. Schmitt

Author Correction: A map of the rubisco biochemical landscape pp. E47-E47

Noam Prywes, Naiya R. Phillips, Luke M. Oltrogge, Sebastian Lindner, Leah J. Taylor-Kearney, Yi-Chin Candace Tsai, Benoit Pins, Aidan E. Cowan, Hana A. Chang, Renée Z. Wang, Laina N. Hall, Daniel Bellieny-Rabelo, Hunter M. Nisonoff, Rachel F. Weissman, Avi I. Flamholz, David Ding, Abhishek Y. Bhatt, Oliver Mueller-Cajar, Patrick M. Shih, Ron Milo and David F. Savage

Author Correction: High fatigue resistance in a titanium alloy via near-void-free 3D printing pp. E48-E48

Zhan Qu, Zhenjun Zhang, Rui Liu, Ling Xu, Yining Zhang, Xiaotao Li, Zhenkai Zhao, Qiqiang Duan, Shaogang Wang, Shujun Li, Yingjie Ma, Xiaohong Shao, Rui Yang, Jürgen Eckert, Robert O. Ritchie and Zhefeng Zhang

Move beyond ‘publish or perish’ by measuring behaviours that benefit academia pp. 861-861

Kelly-Ann Allen

Quantum technologies need big investments to deliver on their big promises pp. 862-862

Jian-Wei Pan

Trump’s siege of science: how the first 30 days unfolded and what’s next pp. 865-867

Jeff Tollefson, Max Kozlov, Alexandra Witze and Dan Garisto

Biggest-ever AI biology model writes DNA on demand pp. 868-869

Ewen Callaway

Rare genetic disorder treated in womb for the first time pp. 869-869

Smriti Mallapaty

Revealed: NIH research grants still frozen despite lawsuits challenging Trump order pp. 870-871

Max Kozlov

Woman in cancer remission for record 19 years after CAR-T immune treatment pp. 871-872

Heidi Ledford

Microsoft claims quantum-computing breakthrough — but some physicists are sceptical pp. 872-872

Davide Castelvecchi

How quickly are you ageing? What molecular ‘clocks’ can tell you about your health pp. 874-876

Heidi Ledford

Can AI help beat poverty? Researchers test ways to aid the poorest people pp. 878-880

Carrie Arnold

Will AI jeopardize science photography? There’s still time to create an ethical code of conduct pp. 881-883

Felice Frankel

The racial injustice laid bare by COVID must not be forgotten pp. 883-884

Annabel Sowemimo

How scientists can drive climate action: celebrate nature and promote hope pp. 885-887

Harini Nagendra

We use 30 billion tonnes of concrete each year — here’s how to make it sustainable pp. 888-890

Jianzhuang Xiao, Shuai Zou, Chi Sun Poon, Man Lung Sham, Zongjin Li and Surendra P. Shah

Sharing benefits of research is key to effective science communication pp. 891-891

Nicolás C. Zanetta-Colombo

National climate policies must address mental health pp. 891-891

Lea Schlatter, Manasi Kumar and Pushpam Kumar

China’s low-altitude economy needs to grow with more caution pp. 891-891

Yong Wang and Dexin Ran

Other countries should copy Nepal’s approach to tackling cervical cancer pp. 891-891

Binod G. C. and Alisha G. C.

Atlantic circulation could be more resilient to global warming than was thought pp. 893-894

Aixue Hu

Skin in the game — locally made antibodies fight resident bacteria pp. 894-896

Jeong-Mi Lee and Peter T. Sage

Superelastic titanium alloy has potential for space missions pp. 896-897

Shaolou Wei and Dierk Raabe

Superkiller complex problems expose a cancer-cell vulnerability pp. 897-899

Christopher U. T. Hellen and Tatyana V. Pestova

Does a cell’s gene expression always reflect its function? pp. 899-900

M. Neşet Özel and Claude Desplan

Mass-spectrometry-based proteomics: from single cells to clinical applications pp. 901-911

Tiannan Guo, Judith A. Steen and Matthias Mann

Scaling and networking a modular photonic quantum computer pp. 912-919

H. Aghaee Rad, T. Ainsworth, R. N. Alexander, B. Altieri, M. F. Askarani, R. Baby, L. Banchi, B. Q. Baragiola, J. E. Bourassa, R. S. Chadwick, I. Charania, H. Chen, M. J. Collins, P. Contu, N. D’Arcy, G. Dauphinais, R. Prins, D. Deschenes, I. Luch, S. Duque, P. Edke, S. E. Fayer, S. Ferracin, H. Ferretti, J. Gefaell, S. Glancy, C. González-Arciniegas, T. Grainge, Z. Han, J. Hastrup, L. G. Helt, T. Hillmann, J. Hundal, S. Izumi, T. Jaeken, M. Jonas, S. Kocsis, I. Krasnokutska, M. V. Larsen, P. Laskowski, F. Laudenbach, J. Lavoie, M. Li, E. Lomonte, C. E. Lopetegui, B. Luey, A. P. Lund, C. Ma, L. S. Madsen, D. H. Mahler, L. Mantilla Calderón, M. Menotti, F. M. Miatto, B. Morrison, P. J. Nadkarni, T. Nakamura, L. Neuhaus, Z. Niu, R. Noro, K. Papirov, A. Pesah, D. S. Phillips, W. N. Plick, T. Rogalsky, F. Rortais, J. Sabines-Chesterking, S. Safavi-Bayat, E. Sazhaev, M. Seymour, K. Rezaei Shad, M. Silverman, S. A. Srinivasan, M. Stephan, Q. Y. Tang, J. F. Tasker, Y. S. Teo, R. B. Then, J. E. Tremblay, I. Tzitrin, V. D. Vaidya, M. Vasmer, Z. Vernon, L. F. S. S. M. Villalobos, B. W. Walshe, R. Weil, X. Xin, X. Yan, Y. Yao, M. Zamani Abnili and Y. Zhang

Hardware-efficient quantum error correction via concatenated bosonic qubits pp. 927-934

Harald Putterman, Kyungjoo Noh, Connor T. Hann, Gregory S. MacCabe, Shahriar Aghaeimeibodi, Rishi N. Patel, Menyoung Lee, William M. Jones, Hesam Moradinejad, Roberto Rodriguez, Neha Mahuli, Jefferson Rose, John Clai Owens, Harry Levine, Emma Rosenfeld, Philip Reinhold, Lorenzo Moncelsi, Joshua Ari Alcid, Nasser Alidoust, Patricio Arrangoiz-Arriola, James Barnett, Przemyslaw Bienias, Hugh A. Carson, Cliff Chen, Li Chen, Harutiun Chinkezian, Eric M. Chisholm, Ming-Han Chou, Aashish Clerk, Andrew Clifford, R. Cosmic, Ana Valdes Curiel, Erik Davis, Laura DeLorenzo, J. Mitchell D’Ewart, Art Diky, Nathan D’Souza, Philipp T. Dumitrescu, Shmuel Eisenmann, Essam Elkhouly, Glen Evenbly, Michael T. Fang, Yawen Fang, Matthew J. Fling, Warren Fon, Gabriel Garcia, Alexey V. Gorshkov, Julia A. Grant, Mason J. Gray, Sebastian Grimberg, Arne L. Grimsmo, Arbel Haim, Justin Hand, Yuan He, Mike Hernandez, David Hover, Jimmy S. C. Hung, Matthew Hunt, Joe Iverson, Ignace Jarrige, Jean-Christophe Jaskula, Liang Jiang, Mahmoud Kalaee, Rassul Karabalin, Peter J. Karalekas, Andrew J. Keller, Amirhossein Khalajhedayati, Aleksander Kubica, Hanho Lee, Catherine Leroux, Simon Lieu, Victor Ly, Keven Villegas Madrigal, Guillaume Marcaud, Gavin McCabe, Cody Miles, Ashley Milsted, Joaquin Minguzzi, Anurag Mishra, Biswaroop Mukherjee, Mahdi Naghiloo, Eric Oblepias, Gerson Ortuno, Jason Pagdilao, Nicola Pancotti, Ashley Panduro, Paquette Jp, Minje Park, Gregory A. Peairs, David Perello, Eric C. Peterson, Sophia Ponte, John Preskill, Johnson Qiao, Gil Refael, Rachel Resnick, Alex Retzker, Omar A. Reyna, Marc Runyan, Colm A. Ryan, Abdulrahman Sahmoud, Ernesto Sanchez, Rohan Sanil, Krishanu Sankar, Yuki Sato, Thomas Scaffidi, Salome Siavoshi, Prasahnt Sivarajah, Trenton Skogland, Chun-Ju Su, Loren J. Swenson, Stephanie M. Teo, Astrid Tomada, Giacomo Torlai, E. Alex Wollack, Yufeng Ye, Jessica A. Zerrudo, Kailing Zhang, Fernando G. S. L. Brandão, Matthew H. Matheny and Oskar Painter

Signatures of ambient pressure superconductivity in thin film La3Ni2O7 pp. 935-940

Eun Kyo Ko, Yijun Yu, Yidi Liu, Lopa Bhatt, Jiarui Li, Vivek Thampy, Cheng-Tai Kuo, Bai Yang Wang, Yonghun Lee, Kyuho Lee, Jun-Sik Lee, Berit H. Goodge, David A. Muller and Harold Y. Hwang

Modulated ringdown comb interferometry for sensing of highly complex gases pp. 941-948

Qizhong Liang, Apoorva Bisht, Andrew Scheck, Peter G. Schunemann and Jun Ye

Perovskite heteroepitaxy for high-efficiency and stable pure-red LEDs pp. 949-956

Keyu Wei, Tong Zhou, Yuanzhi Jiang, Changjiu Sun, Yulong Liu, Saisai Li, Siyu Liu, Xinliang Fu, Cejun Hu, Shun Tian, Yingguo Yang, Xuewen Fu, Najla AlMasoud, Saif M. H. Qaid, Mohammad Khaja Nazeeruddin, Hsien-Yi Hsu, Wen-Di Li, Ji Tae Kim, Run Long, Wei Zhang, Jun Chen and Mingjian Yuan

Hypotaxy of wafer-scale single-crystal transition metal dichalcogenides pp. 957-964

Donghoon Moon, Wonsik Lee, Chaesung Lim, Jinwoo Kim, Jiwoo Kim, Yeonjoon Jung, Hyun-Young Choi, Won Seok Choi, Hangyel Kim, Ji-Hwan Baek, Changheon Kim, Jaewoong Joo, Hyun-Geun Oh, Hajung Jang, Kenji Watanabe, Takashi Taniguchi, Sukang Bae, Jangyup Son, Huije Ryu, Junyoung Kwon, Hyeonsik Cheong, Jeong Woo Han, Hyejin Jang and Gwan-Hyoung Lee

A lightweight shape-memory alloy with superior temperature-fluctuation resistance pp. 965-971

Yuxin Song, Sheng Xu, Shunsuke Sato, Inho Lee, Xiao Xu, Toshihiro Omori, Makoto Nagasako, Takuro Kawasaki, Ryoji Kiyanagi, Stefanus Harjo, Wu Gong, Tomáš Grabec, Pavla Stoklasová and Ryosuke Kainuma

Thermal Ca2+/Mg2+ exchange reactions to synthesize CO2 removal materials pp. 972-979

Yuxuan Chen and Matthew W. Kanan

Total synthesis of 25 picrotoxanes by virtual library selection pp. 980-986

Chunyu Li and Ryan A. Shenvi

Continued Atlantic overturning circulation even under climate extremes pp. 987-994

J. A. Baker, M. J. Bell, L. C. Jackson, G. K. Vallis, A. J. Watson and R. A. Wood

Warming and cooling catalyse widespread temporal turnover in biodiversity pp. 995-999

Malin L. Pinsky, Helmut Hillebrand, Jonathan M. Chase, Laura H. Antão, Myriam R. Hirt, Ulrich Brose, Michael T. Burrows, Benoit Gauzens, Benjamin Rosenbaum and Shane A. Blowes

Widespread occurrence and relevance of phosphate storage in foraminifera pp. 1000-1006

Nicolaas Glock, Julien Richirt, Christian Woehle, Christopher Algar, Maria Armstrong, Daniela Eichner, Hanna Firrincieli, Akiko Makabe, Anjaly Govindankutty Menon, Yoshiyuki Ishitani, Thomas Hackl, Raphaël Hubert-Huard, Markus Kienast, Yvonne Milker, André Mutzberg, Sha Ni, Satoshi Okada, Subhadeep Rakshit, Gerhard Schmiedl, Zvi Steiner, Akihiro Tame, Zhouling Zhang and Hidetaka Nomaki

Ancient DNA reveals reproductive barrier despite shared Avar-period culture pp. 1007-1014

Ke Wang, Bendeguz Tobias, Doris Pany-Kucera, Margit Berner, Sabine Eggers, Guido Alberto Gnecchi-Ruscone, Denisa Zlámalová, Joscha Gretzinger, Pavlína Ingrová, Adam B. Rohrlach, Jonathan Tuke, Luca Traverso, Paul Klostermann, Robin Koger, Ronny Friedrich, Karin Wiltschke-Schrotta, Sylvia Kirchengast, Salvatore Liccardo, Sandra Wabnitz, Tivadar Vida, Patrick J. Geary, Falko Daim, Walter Pohl, Johannes Krause and Zuzana Hofmanová

Learned magnetic map cues and two mechanisms of magnetoreception in turtles pp. 1015-1022

Kayla M. Goforth, Catherine M. F. Lohmann, Andrew Gavin, Reyco Henning, Andrew Harvey, Tara L. Hinton, Dana S. Lim and Kenneth J. Lohmann

Transcriptomic neuron types vary topographically in function and morphology pp. 1023-1033

Inbal Shainer, Johannes M. Kappel, Eva Laurell, Joseph C. Donovan, Martin W. Schneider, Enrico Kuehn, Irene Arnold-Ammer, Manuel Stemmer, Johannes Larsch and Herwig Baier

Ensemble reactivations during brief rest drive fast learning of sequences pp. 1034-1042

Sandon Griffin, Preeya Khanna, Hoseok Choi, Katherina Thiesen, Lisa Novik, Robert J. Morecraft and Karunesh Ganguly

Skin autonomous antibody production regulates host–microbiota interactions pp. 1043-1053

Inta Gribonika, Victor I. Band, Liang Chi, Paula Juliana Perez-Chaparro, Verena M. Link, Eduard Ansaldo, Cihan Oguz, Djenet Bousbaine, Michael A. Fischbach and Yasmine Belkaid

Discovery and engineering of the antibody response to a prominent skin commensal pp. 1054-1064

Djenet Bousbaine, Katherine D. Bauman, Y. Erin Chen, Pranav V. Lalgudi, Tam T. D. Nguyen, Joyce M. Swenson, Victor K. Yu, Eunice Tsang, Sean Conlan, David B. Li, Amina Jbara, Aishan Zhao, Arash Naziripour, Alessandra Veinbachs, Yu E. Lee, Jennie L. Phung, Alex Dimas, Sunit Jain, Xiandong Meng, Thi Phuong Thao Pham, Martin I. McLaughlin, Layla J. Barkal, Inta Gribonika, Koen K. A. Van Rompay, Heidi H. Kong, Julia A. Segre, Yasmine Belkaid, Christopher O. Barnes and Michael A. Fischbach

Mapping cells through time and space with moscot pp. 1065-1075

Dominik Klein, Giovanni Palla, Marius Lange, Michal Klein, Zoe Piran, Manuel Gander, Laetitia Meng-Papaxanthos, Michael Sterr, Lama Saber, Changying Jing, Aimée Bastidas-Ponce, Perla Cota, Marta Tarquis-Medina, Shrey Parikh, Ilan Gold, Heiko Lickert, Mostafa Bakhti, Mor Nitzan, Marco Cuturi and Fabian J. Theis

IL-33-activated ILC2s induce tertiary lymphoid structures in pancreatic cancer pp. 1076-1084

Masataka Amisaki, Abderezak Zebboudj, Hiroshi Yano, Siqi Linsey Zhang, George Payne, Adrienne Kaya Chandra, Rebecca Yu, Pablo Guasp, Zachary M. Sethna, Akihiro Ohmoto, Luis A. Rojas, Charlotte Cheng, Theresa Waters, Alexander Solovyov, Stephen Martis, Ashley S. Doane, Charlotte Reiche, Emmanuel M. Bruno, Martina Milighetti, Kevin Soares, Zagaa Odgerel, John Alec Moral, Julia N. Zhao, Mithat Gönen, Rui Gardner, Alexei V. Tumanov, Abdul G. Khan, Olivia Vergnolle, Elisabeth K. Nyakatura, Ivo C. Lorenz, Manuel Baca, Erin Patterson, Benjamin Greenbaum, David Artis, Taha Merghoub and Vinod P. Balachandran

A cell atlas foundation model for scalable search of similar human cells pp. 1085-1094

Graham Heimberg, Tony Kuo, Daryle J. DePianto, Omar Salem, Tobias Heigl, Nathaniel Diamant, Gabriele Scalia, Tommaso Biancalani, Shannon J. Turley, Jason R. Rock, Héctor Corrada Bravo, Josh Kaminker, Jason A. Vander Heiden and Aviv Regev

Synthetic lethality of mRNA quality control complexes in cancer pp. 1095-1103

Vivian Prindle, Adam E. Richardson, Kimberly R. Sher, Sarah Kongpachith, Kaitlin Kentala, Sakina Petiwala, Dong Cheng, Deborah Widomski, Phuong Le, Maricel Torrent, Anlu Chen, Stephen Walker, Marianne B. Palczewski, Diya Mitra, Vlasios Manaves, Xu Shi, Charles Lu, Stephanie Sandoval, Zoltan Dezso, F. Gregory Buchanan, Daniel Verduzco, Brian Bierie, Jonathan A. Meulbroek, William N. Pappano and Joshua P. Plotnik

SKI complex loss renders 9p21.3-deleted or MSI-H cancers dependent on PELO pp. 1104-1111

Patricia C. Borck, Isabella Boyle, Kristina Jankovic, Nolan Bick, Kyla Foster, Anthony C. Lau, Lucy I. Parker-Burns, Daniel A. Lubicki, Tianxia Li, Ashir A. Borah, Nicholas J. Lofaso, Sohani Sharma, Tessla Chan, Riya V. Kishen, Anisah Adeagbo, Srivatsan Raghavan, Elisa Aquilanti, John R. Prensner, J. Michael Krill-Burger, Todd R. Golub, Catarina D. Campbell, Joshua M. Dempster, Edmond M. Chan and Francisca Vazquez

Targeting FOXM1 condensates reduces breast tumour growth and metastasis pp. 1112-1121

Feng Xie, Xiaoxue Zhou, Yu Ran, Ran Li, Jing Zou, Shiyun Wan, Peng Su, Xuli Meng, Haiyan Yan, Huasong Lu, Heng Ru, Hai Hu, Zhengwei Mao, Bing Yang, Fangfang Zhou and Long Zhang

RNA control of reverse transcription in a diversity-generating retroelement pp. 1122-1129

Sumit Handa, Tapan Biswas, Jeet Chakraborty, Gourisankar Ghosh, Blair G. Paul and Partho Ghosh

The sequence–structure–function relationship of intrinsic ERα disorder pp. 1130-1138

Zhanwen Du, Han Wang, Shuqi Luo, Zixi Yun, Chen Wu, Wangfei Yang, Matthias Buck, Wenwei Zheng, Alexandar L. Hansen, Hung-Ying Kao and Sichun Yang

PhD scientists who forged a career off the beaten track pp. 1139-1141

Katie L. Burke

Chasing wildcats with my daughter pp. 1144-1144

Ugo Mellone

2025, volume 638, articles 8051

Sequence clustering confounds AlphaFold2 pp. E8-E12

Joseph W. Schafer, Myeongsang Lee, Devlina Chakravarty, Joseph F. Thole, Ethan A. Chen and Lauren L. Porter

Atlantic oceanic droughts do not threaten Asian water tower pp. E13-E15

Yutong Zhao, Chaoyi Xu, Xiaoyu Yu, Yigang Liu and Xinhui Ji

Reply to: Atlantic oceanic droughts do not threaten Asian water tower pp. E16-E18

Qiang Zhang, Zexi Shen, Yadu Pokhrel, Daniel Farinotti, Vijay P. Singh, Chong-Yu Xu, Wenhuan Wu and Gang Wang

Insufficient evidence for natural selection associated with the Black Death pp. E19-E22

Alison R. Barton, Cindy G. Santander, Pontus Skoglund, Ida Moltke, David Reich and Iain Mathieson

Reply to: Insufficient evidence for natural selection associated with the Black Death pp. E23-E29

Tauras P. Vilgalys, Jennifer Klunk, Christian E. Demeure, Xiaoheng Cheng, Mari Shiratori, Julien Madej, Rémi Beau, Derek Elli, Maria I. Patino, Rebecca Redfern, Sharon N. DeWitte, Julia A. Gamble, Jesper L. Boldsen, Ann Carmichael, Nükhet Varlik, Katherine Eaton, Jean-Christophe Grenier, G. Brian Golding, Alison Devault, Jean-Marie Rouillard, Vania Yotova, Renata Sindeaux, Chun Jimmie Ye, Matin Bikaran, Anne Dumaine, Jessica F. Brinkworth, Dominique Missiakas, Guy A. Rouleau, Matthias Steinrücken, Javier Pizarro-Cerdá, Hendrik N. Poinar and Luis B. Barreiro

Author Correction: FBP1 controls liver cancer evolution from senescent MASH hepatocytes pp. E30-E30

Li Gu, Yahui Zhu, Shuvro P. Nandi, Maiya Lee, Kosuke Watari, Breanna Bareng, Masafumi Ohira, Yuxiao Liu, Sadatsugu Sakane, Rodrigo Carlessi, Consuelo Sauceda, Debanjan Dhar, Souradipta Ganguly, Mojgan Hosseini, Marcos G. Teneche, Peter D. Adams, David J. Gonzalez, Tatiana Kisseleva, Janina E. E. Tirnitz-Parker, M. Celeste Simon, Ludmil B. Alexandrov and Michael Karin

Author Correction: Stromal changes in the aged lung induce an emergence from melanoma dormancy pp. E31-E31

Mitchell E. Fane, Yash Chhabra, Gretchen M. Alicea, Devon A. Maranto, Stephen M. Douglass, Marie R. Webster, Vito W. Rebecca, Gloria E. Marino, Filipe Almeida, Brett L. Ecker, Daniel J. Zabransky, Laura Hüser, Thomas Beer, Hsin-Yao Tang, Andrew Kossenkov, Meenhard Herlyn, David W. Speicher, Wei Xu, Xiaowei Xu, Elizabeth M. Jaffee, Julio A. Aguirre-Ghiso and Ashani T. Weeraratna

Publisher Correction: Placenta-tropic VEGF mRNA lipid nanoparticles ameliorate murine pre-eclampsia pp. E33-E33

Kelsey L. Swingle, Alex G. Hamilton, Hannah C. Safford, Hannah C. Geisler, Ajay S. Thatte, Rohan Palanki, Amanda M. Murray, Emily L. Han, Alvin J. Mukalel, Xuexiang Han, Ryann A. Joseph, Aditi A. Ghalsasi, Mohamad-Gabriel Alameh, Drew Weissman and Michael J. Mitchell

Editorial Expression of Concern: 53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark pp. E34-E34

Amélie Fradet-Turcotte, Marella D. Canny, Cristina Escribano-Díaz, Alexandre Orthwein, Charles C. Y. Leung, Hao Huang, Marie-Claude Landry, Julianne Kitevski-LeBlanc, Sylvie M. Noordermeer, Frank Sicheri and Daniel Durocher

These Gaza scientists are keeping research alive amid war, destruction and uncertainty pp. 587-588

Michele Catanzaro

DeepMind AI crushes tough maths problems on par with top human solvers pp. 589-589

Davide Castelvecchi

Scientists globally are racing to save vital health databases taken down amid Trump chaos pp. 589-590

Smriti Mallapaty

How centuries of isolation shaped Greenlanders’ unique genetics pp. 590-591

Freda Kreier

The weight-loss drugs being tested in 2025: will they beat Ozempic? pp. 591-592

Giorgia Guglielmi

Are PhDs losing their lustre? Why fewer students are enrolling in doctoral degrees pp. 592-593

Diana Kwon

Earth’s mysterious inner core really is changing shape pp. 593-594

Alexandra Witze

A man was destined for early Alzheimer’s — these genes might explain his escape pp. 594-594

Sara Reardon

Exclusive: These universities have the most retracted scientific articles pp. 596-599

Richard Van Noorden

Migraine is more than a headache — a radical rethink offers hope to one billion people pp. 600-602

Fred Schwaller

Money and murder: the dark side of the Asilomar meeting on recombinant DNA pp. 603-606

Matthew Cobb

Researchers overlooked airborne diseases for centuries — then COVID-19 changed everything pp. 607-608

Linsey C. Marr

China made waves with Deepseek, but its real ambition is AI-driven industrial innovation pp. 609-611

Jacob Dreyer

Poetry on Mars and robots on Earth: Books in brief pp. 611-611

Andrew Robinson

Federico Mayor Zaragoza obituary: former UNESCO chief who championed neonatal screening pp. 613-613

Jesús Avila, Federico Mayor and Paola Bovolenta

A sustainable ocean needs thriving ocean societies pp. 614-614

Joachim Claudet, Jessica Blythe and David Gill

Charles Darwin saw the importance of development in evolution pp. 614-614

Yongsheng Liu

Don’t overlook the mental-health costs of California’s wildfires pp. 614-614

Shir Mor-Ben-Ishai, Yafit Levin and Menachem Ben-Ezra

A giant leap for machine translation could be even bigger pp. 614-614

Chao Su

Conservation strategies aided by assessment of global genetic diversity pp. 615-616

David Nogués-Bravo and Carsten Rahbek

The secrets of static electricity are finally being revealed pp. 616-618

Daniel J. Lacks and Mamadou Sow

The structure of bad cholesterol comes into focus pp. 618-620

W. Sean Davidson

Ancient human genomes offer clues about the earliest migrations out of Africa pp. 620-621

María Martinón-Torres and Carles Lalueza-Fox

Artificial intelligence for modelling infectious disease epidemics pp. 623-635

Moritz U. G. Kraemer, Joseph L.-H. Tsui, Serina Y. Chang, Spyros Lytras, Mark P. Khurana, Samantha Vanderslott, Sumali Bajaj, Neil Scheidwasser, Jacob Liam Curran-Sebastian, Elizaveta Semenova, Mengyan Zhang, H. Juliette T. Unwin, Oliver J. Watson, Cathal Mills, Abhishek Dasgupta, Luca Ferretti, Samuel V. Scarpino, Etien Koua, Oliver Morgan, Houriiyah Tegally, Ulrich Paquet, Loukas Moutsianas, Christophe Fraser, Neil M. Ferguson, Eric J. Topol, David A. Duchêne, Tanja Stadler, Patricia Kingori, Michael J. Parker, Francesca Dominici, Nigel Shadbolt, Marc A. Suchard, Oliver Ratmann, Seth Flaxman, Edward C. Holmes, Manuel Gomez-Rodriguez, Bernhard Schölkopf, Christl A. Donnelly, Oliver G. Pybus, Simon Cauchemez and Samir Bhatt

Hydrogen escaping from a pair of exoplanets smaller than Neptune pp. 636-639

R. O. Parke Loyd, Ethan Schreyer, James E. Owen, James G. Rogers, Madelyn I. Broome, Evgenya L. Shkolnik, Ruth Murray-Clay, David J. Wilson, Sarah Peacock, Johanna Teske, Hilke E. Schlichting, Girish M. Duvvuri, Allison Youngblood, P. Christian Schneider, Kevin France, Steven Giacalone, Natasha E. Batalha, Adam C. Schneider, Isabella Longo, Travis Barman and David R. Ardila

Direct experimental constraints on the spatial extent of a neutrino wavepacket pp. 640-644

Joseph Smolsky, Kyle G. Leach, Ryan Abells, Pedro Amaro, Adrien Andoche, Keith Borbridge, Connor Bray, Robin Cantor, David Diercks, Spencer Fretwell, Stephan Friedrich, Abigail Gillespie, Mauro Guerra, Ad Hall, Cameron N. Harris, Jackson T. Harris, Leendert M. Hayen, Paul-Antoine Hervieux, Calvin Hinkle, Geon-Bo Kim, Inwook Kim, Amii Lamm, Annika Lennarz, Vincenzo Lordi, Jorge Machado, Andrew Marino, David McKeen, Xavier Mougeot, Francisco Ponce, Chris Ruiz, Amit Samanta, José Paulo Santos, Caitlyn Stone-Whitehead, John Taylor, Joseph Templet, Sriteja Upadhyayula, Louis Wagner and William K. Warburton

Manipulation of the altermagnetic order in CrSb via crystal symmetry pp. 645-650

Zhiyuan Zhou, Xingkai Cheng, Mengli Hu, Ruiyue Chu, Hua Bai, Lei Han, Junwei Liu, Feng Pan and Cheng Song

Interferometric single-shot parity measurement in InAs–Al hybrid devices pp. 651-655

Morteza Aghaee, Alejandro Alcaraz Ramirez, Zulfi Alam, Rizwan Ali, Mariusz Andrzejczuk, Andrey Antipov, Mikhail Astafev, Amin Barzegar, Bela Bauer, Jonathan Becker, Umesh Kumar Bhaskar, Alex Bocharov, Srini Boddapati, David Bohn, Jouri Bommer, Leo Bourdet, Arnaud Bousquet, Samuel Boutin, Lucas Casparis, Benjamin J. Chapman, Sohail Chatoor, Anna Wulff Christensen, Cassandra Chua, Patrick Codd, William Cole, Paul Cooper, Fabiano Corsetti, Ajuan Cui, Paolo Dalpasso, Juan Pablo Dehollain, Gijs Lange, Michiel Moor, Andreas Ekefjärd, Tareq El Dandachi, Juan Carlos Estrada Saldaña, Saeed Fallahi, Luca Galletti, Geoff Gardner, Deshan Govender, Flavio Griggio, Ruben Grigoryan, Sebastian Grijalva, Sergei Gronin, Jan Gukelberger, Marzie Hamdast, Firas Hamze, Esben Bork Hansen, Sebastian Heedt, Zahra Heidarnia, Jesús Herranz Zamorano, Samantha Ho, Laurens Holgaard, John Hornibrook, Jinnapat Indrapiromkul, Henrik Ingerslev, Lovro Ivancevic, Thomas Jensen, Jaspreet Jhoja, Jeffrey Jones, Konstantin V. Kalashnikov, Ray Kallaher, Rachpon Kalra, Farhad Karimi, Torsten Karzig, Evelyn King, Maren Elisabeth Kloster, Christina Knapp, Dariusz Kocon, Jonne V. Koski, Pasi Kostamo, Mahesh Kumar, Tom Laeven, Thorvald Larsen, Jason Lee, Kyunghoon Lee, Grant Leum, Kongyi Li, Tyler Lindemann, Matthew Looij, Julie Love, Marijn Lucas, Roman Lutchyn, Morten Hannibal Madsen, Nash Madulid, Albert Malmros, Michael Manfra, Devashish Mantri, Signe Brynold Markussen, Esteban Martinez, Marco Mattila, Robert McNeil, Antonio B. Mei, Ryan V. Mishmash, Gopakumar Mohandas, Christian Mollgaard, Trevor Morgan, George Moussa, Chetan Nayak, Jens Hedegaard Nielsen, Jens Munk Nielsen, William Hvidtfelt Padkar Nielsen, Bas Nijholt, Mike Nystrom, Eoin O’Farrell, Thomas Ohki, Keita Otani, Brian Paquelet Wütz, Sebastian Pauka, Karl Petersson, Luca Petit, Dima Pikulin, Guen Prawiroatmodjo, Frank Preiss, Eduardo Puchol Morejon, Mohana Rajpalke, Craig Ranta, Katrine Rasmussen, David Razmadze, Outi Reentila, David J. Reilly, Yuan Ren, Ken Reneris, Richard Rouse, Ivan Sadovskyy, Lauri Sainiemi, Irene Sanlorenzo, Emma Schmidgall, Cristina Sfiligoj, Mustafeez Bashir Shah, Kevin Simoes, Shilpi Singh, Sarat Sinha, Thomas Soerensen, Patrick Sohr, Tomas Stankevic, Lieuwe Stek, Eric Stuppard, Henri Suominen, Judith Suter, Sam Teicher, Nivetha Thiyagarajah, Raj Tholapi, Mason Thomas, Emily Toomey, Josh Tracy, Michelle Turley, Shivendra Upadhyay, Ivan Urban, Kevin Hoogdalem, David J. Woerkom, Dmitrii V. Viazmitinov, Dominik Vogel, John Watson, Alex Webster, Joseph Weston, Georg W. Winkler, Di Xu, Chung Kai Yang, Emrah Yucelen, Roland Zeisel, Guoji Zheng and Justin Zilke

World and Human Action Models towards gameplay ideation pp. 656-663

Anssi Kanervisto, Dave Bignell, Linda Yilin Wen, Martin Grayson, Raluca Georgescu, Sergio Valcarcel Macua, Shan Zheng Tan, Tabish Rashid, Tim Pearce, Yuhan Cao, Abdelhak Lemkhenter, Chentian Jiang, Gavin Costello, Gunshi Gupta, Marko Tot, Shu Ishida, Tarun Gupta, Udit Arora, Ryen W. White, Sam Devlin, Cecily Morrison and Katja Hofmann

Spontaneous ordering of identical materials into a triboelectric series pp. 664-669

Juan Carlos Sobarzo, Felix Pertl, Daniel M. Balazs, Tommaso Costanzo, Markus Sauer, Annette Foelske, Markus Ostermann, Christian M. Pichler, Yongkang Wang, Yuki Nagata, Mischa Bonn and Scott Waitukaitis

Aqueous-based recycling of perovskite photovoltaics pp. 670-675

Xun Xiao, Niansheng Xu, Xueyu Tian, Tiankai Zhang, Bingzheng Wang, Xiaoming Wang, Yeming Xian, Chunyuan Lu, Xiangyu Ou, Yanfa Yan, Licheng Sun, Fengqi You and Feng Gao

External Li supply reshapes Li deficiency and lifetime limit of batteries pp. 676-683

Shu Chen, Guanbin Wu, Haibo Jiang, Jifeng Wang, Tiantian Chen, Chenyang Han, Wenwen Wang, Rongchen Yang, Jiahua Zhao, Zhihang Tang, Xiaocheng Gong, Chuanfa Li, Mengyao Zhu, Kun Zhang, Yifei Xu, Ying Wang, Zhe Hu, Peining Chen, Bingjie Wang, Kai Zhang, Yongyao Xia, Huisheng Peng and Yue Gao

Stronger and coarser-grained biodegradable zinc alloys pp. 684-689

Chengcheng Wu, Fengxiang Lin, Hong Liu, Matthew H. Pelletier, Max Lloyd, Williams R. Walsh and Jian-Feng Nie

Shielding Pt/γ-Mo2N by inert nano-overlays enables stable H2 production pp. 690-696

Zirui Gao, Aowen Li, Xingwu Liu, Mi Peng, Shixiang Yu, Maolin Wang, Yuzhen Ge, Chengyu Li, Tie Wang, Zhaohua Wang, Wu Zhou and Ding Ma

Aromatic ring-opening metathesis pp. 697-703

Valeriia Hutskalova and Christof Sparr

Global meta-analysis shows action is needed to halt genetic diversity loss pp. 704-710

Robyn E. Shaw, Katherine A. Farquharson, Michael W. Bruford, David J. Coates, Carole P. Elliott, Joachim Mergeay, Kym M. Ottewell, Gernot Segelbacher, Sean Hoban, Christina Hvilsom, Sílvia Pérez-Espona, Dainis Ruņģis, Filippos Aravanopoulos, Laura D. Bertola, Helena Cotrim, Karen Cox, Vlatka Cubric-Curik, Robert Ekblom, José A. Godoy, Maciej K. Konopiński, Linda Laikre, Isa-Rita M. Russo, Nevena Veličković, Philippine Vergeer, Carles Vilà, Vladimir Brajkovic, David L. Field, William P. Goodall-Copestake, Frank Hailer, Tara Hopley, Frank E. Zachos, Paulo C. Alves, Aleksandra Biedrzycka, Rachel M. Binks, Joukje Buiteveld, Elena Buzan, Margaret Byrne, Barton Huntley, Laura Iacolina, Naomi L. P. Keehnen, Peter Klinga, Alexander Kopatz, Sara Kurland, Jennifer A. Leonard, Chiara Manfrin, Alexis Marchesini, Melissa A. Millar, Pablo Orozco-terWengel, Jente Ottenburghs, Diana Posledovich, Peter B. Spencer, Nikolaos Tourvas, Tina Unuk Nahberger, Pim Hooft, Rita Verbylaite, Cristiano Vernesi and Catherine E. Grueber

Earliest modern human genomes constrain timing of Neanderthal admixture pp. 711-717

Arev P. Sümer, Hélène Rougier, Vanessa Villalba-Mouco, Yilei Huang, Leonardo N. M. Iasi, Elena Essel, Alba Bossoms Mesa, Anja Furtwaengler, Stéphane Peyrégne, Cesare Filippo, Adam B. Rohrlach, Federica Pierini, Fabrizio Mafessoni, Helen Fewlass, Elena I. Zavala, Dorothea Mylopotamitaki, Raffaela A. Bianco, Anna Schmidt, Julia Zorn, Birgit Nickel, Anna Patova, Cosimo Posth, Geoff M. Smith, Karen Ruebens, Virginie Sinet-Mathiot, Alexander Stoessel, Holger Dietl, Jörg Orschiedt, Janet Kelso, Hugo Zeberg, Kirsten I. Bos, Frido Welker, Marcel Weiss, Shannon P. McPherron, Tim Schüler, Jean-Jacques Hublin, Petr Velemínský, Jaroslav Brůžek, Benjamin M. Peter, Matthias Meyer, Harald Meller, Harald Ringbauer, Mateja Hajdinjak, Kay Prüfer and Johannes Krause

Expanding the human gut microbiome atlas of Africa pp. 718-728

Dylan G. Maghini, Ovokeraye H. Oduaran, Luicer A. Ingasia Olubayo, Jane A. Cook, Natalie Smyth, Theophilous Mathema, Carl W. Belger, Godfred Agongo, Palwendé R. Boua, Solomon S. R. Choma, F. Xavier Gómez-Olivé, Isaac Kisiangani, Given R. Mashaba, Lisa Micklesfield, Shukri F. Mohamed, Engelbert A. Nonterah, Shane Norris, Hermann Sorgho, Stephen Tollman, Floidy Wafawanaka, Furahini Tluway, Michèle Ramsay, Jakob Wirbel, Ami S. Bhatt and Scott Hazelhurst

Prolonged persistence of mutagenic DNA lesions in somatic cells pp. 729-738

Michael Spencer Chapman, Emily Mitchell, Kenichi Yoshida, Nicholas Williams, Margarete A. Fabre, Anna Maria Ranzoni, Philip S. Robinson, Lori D. Kregar, Matthias Wilk, Steffen Boettcher, Krishnaa Mahbubani, Kourosh Saeb Parsy, Kate H. C. Gowers, Sam M. Janes, Stanley W. K. Ng, Matt Hoare, Anthony R. Green, George S. Vassiliou, Ana Cvejic, Markus G. Manz, Elisa Laurenti, Iñigo Martincorena, Michael R. Stratton, Jyoti Nangalia, Tim H. H. Coorens and Peter J. Campbell

Episodic and associative memory from spatial scaffolds in the hippocampus pp. 739-751

Sarthak Chandra, Sugandha Sharma, Rishidev Chaudhuri and Ila Fiete

Autoactive CNGC15 enhances root endosymbiosis in legume and wheat pp. 752-759

Nicola M. Cook, Giulia Gobbato, Catherine N. Jacott, Clemence Marchal, Chen Yun Hsieh, Anson Ho Ching Lam, James Simmonds, Pablo Cerro, Pilar Navarro Gomez, Clemence Rodney, Neftaly Cruz-Mireles, Cristobal Uauy, Wilfried Haerty, David M. Lawson and Myriam Charpentier

RELMβ sets the threshold for microbiome-dependent oral tolerance pp. 760-768

Emmanuel Stephen-Victor, Gavin A. Kuziel, Monica Martinez-Blanco, Bat-Erdene Jugder, Mehdi Benamar, Ziwei Wang, Qian Chen, Gabriel L. Lozano, Azza Abdel-Gadir, Ye Cui, Jason Fong, Elisa Saint-Denis, Iris Chang, Kari C. Nadeau, Wanda Phipatanakul, Angela Zhang, Farida Abi Farraj, Faye Holder-Niles, Daniel Zeve, David T. Breault, Klaus Schmitz-Abe, Rima Rachid, Elena Crestani, Seth Rakoff-Nahoum and Talal A. Chatila

A vision–language foundation model for precision oncology pp. 769-778

Jinxi Xiang, Xiyue Wang, Xiaoming Zhang, Yinghua Xi, Feyisope Eweje, Yijiang Chen, Yuchen Li, Colin Bergstrom, Matthew Gopaulchan, Ted Kim, Kun-Hsing Yu, Sierra Willens, Francesca Maria Olguin, Jeffrey J. Nirschl, Joel Neal, Maximilian Diehn, Sen Yang and Ruijiang Li

Multiscale footprints reveal the organization of cis-regulatory elements pp. 779-786

Yan Hu, Max A. Horlbeck, Ruochi Zhang, Sai Ma, Rojesh Shrestha, Vinay K. Kartha, Fabiana M. Duarte, Conrad Hock, Rachel E. Savage, Ajay Labade, Heidi Kletzien, Alia Meliki, Andrew Castillo, Neva C. Durand, Eugenio Mattei, Lauren J. Anderson, Tristan Tay, Andrew S. Earl, Noam Shoresh, Charles B. Epstein, Amy J. Wagers and Jason D. Buenrostro

Transferrin receptor targeting chimeras for membrane protein degradation pp. 787-795

Dingpeng Zhang, Jhoely Duque-Jimenez, Francesco Facchinetti, Garyk Brixi, Kaitlin Rhee, William W. Feng, Pasi A. Jänne and Xin Zhou

Designed endocytosis-inducing proteins degrade targets and amplify signals pp. 796-804

Buwei Huang, Mohamad Abedi, Green Ahn, Brian Coventry, Isaac Sappington, Cong Tang, Rong Wang, Thomas Schlichthaerle, Jason Z. Zhang, Yujia Wang, Inna Goreshnik, Ching Wen Chiu, Adam Chazin-Gray, Sidney Chan, Stacey Gerben, Analisa Murray, Shunzhi Wang, Jason O’Neill, Li Yi, Ronald Yeh, Ayesha Misquith, Anitra Wolf, Luke M. Tomasovic, Dan I. Piraner, Maria J. Duran Gonzalez, Nathaniel R. Bennett, Preetham Venkatesh, Maggie Ahlrichs, Craig Dobbins, Wei Yang, Xinru Wang, Danny D. Sahtoe, Dionne Vafeados, Rubul Mout, Shirin Shivaei, Longxing Cao, Lauren Carter, Lance Stewart, Jamie B. Spangler, Kole T. Roybal, Per Jr Greisen, Xiaochun Li, Gonçalo J. L. Bernardes, Carolyn R. Bertozzi and David Baker

Engineered receptors for soluble cellular communication and disease sensing pp. 805-813

Dan I. Piraner, Mohamad H. Abedi, Maria J. Duran Gonzalez, Adam Chazin-Gray, Annie Lin, Iowis Zhu, Pavithran T. Ravindran, Thomas Schlichthaerle, Buwei Huang, Tyler H. Bearchild, David Lee, Sarah Wyman, Young-wook Jun, David Baker and Kole T. Roybal

Satellite DNA shapes dictate pericentromere packaging in female meiosis pp. 814-822

Damian Dudka, Jennine M. Dawicki-McKenna, Xueqi Sun, Keagan Beeravolu, Takashi Akera, Michael A. Lampson and Ben E. Black

A map of the rubisco biochemical landscape pp. 823-828

Noam Prywes, Naiya R. Phillips, Luke M. Oltrogge, Sebastian Lindner, Leah J. Taylor-Kearney, Yi-Chin Candace Tsai, Benoit Pins, Aidan E. Cowan, Hana A. Chang, Renée Z. Wang, Laina N. Hall, Daniel Bellieny-Rabelo, Hunter M. Nisonoff, Rachel F. Weissman, Avi I. Flamholz, David Ding, Abhishek Y. Bhatt, Oliver Mueller-Cajar, Patrick M. Shih, Ron Milo and David F. Savage

Structure of apolipoprotein B100 bound to the low-density lipoprotein receptor pp. 829-835

Mart Reimund, Altaira D. Dearborn, Giorgio Graziano, Haotian Lei, Anthony M. Ciancone, Ashish Kumar, Ronald Holewinski, Edward B. Neufeld, Francis J. O’Reilly, Alan T. Remaley and Joseph Marcotrigiano

The structure of apolipoprotein B100 from human low-density lipoprotein pp. 836-843

Zachary T. Berndsen and C. Keith Cassidy

Retraction Note: A mechanism for the suppression of homologous recombination in G1 cells pp. 844-844

Alexandre Orthwein, Sylvie M. Noordermeer, Marcus D. Wilson, Sébastien Landry, Radoslav I. Enchev, Alana Sherker, Meagan Munro, Jordan Pinder, Jayme Salsman, Graham Dellaire, Bing Xia, Matthias Peter and Daniel Durocher

Here’s how to bag a hefty research prize to turbocharge innovation pp. 845-847

Rachel Brazil

Why is it so hard to rewrite a genome? pp. 848-850

Michael Eisenstein

‘Talking won’t save the planet’: uniting efforts to save Panama’s parks pp. 852-852

Esme Hedley

2025, volume 638, articles 8050

Author Correction: Synthetic GPCRs for programmable sensing and control of cell behaviour pp. E2-E2

Nicholas A. Kalogriopoulos, Reika Tei, Yuqi Yan, Peter M. Klein, Matthew Ravalin, Bo Cai, Ivan Soltesz, Yulong Li and Alice Y. Ting

Author Correction: An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA pp. E3-E3

Yoshiko Maida, Mami Yasukawa, Miho Furuuchi, Timo Lassmann, Richard Possemato, Naoko Okamoto, Vivi Kasim, Yoshihide Hayashizaki, William C. Hahn and Kenkichi Masutomi

Author Correction: Gut microbiota strain richness is species specific and affects engraftment pp. E4-E4

Alice Chen-Liaw, Varun Aggarwala, Ilaria Mogno, Craig Haifer, Zhihua Li, Joseph Eggers, Drew Helmus, Amy Hart, Jan Wehkamp, Esi S. N. Lamousé-Smith, Robert L. Kerby, Federico E. Rey, Jean Frédéric Colombel, Michael A. Kamm, Bernat Olle, Jason M. Norman, Rajita Menon, Andrea R. Watson, Emily Crossette, Elisabeth M. Terveer, Josbert J. Keller, Thomas J. Borody, Ari Grinspan, Sudarshan Paramsothy, Nadeem O. Kaakoush, Marla C. Dubinsky and Jeremiah J. Faith

Author Correction: Continental influx and pervasive matrilocality in Iron Age Britain pp. E5-E5

Lara M. Cassidy, Miles Russell, Martin Smith, Gabrielle Delbarre, Paul Cheetham, Harry Manley, Valeria Mattiangeli, Emily M. Breslin, Iseult Jackson, Maeve McCann, Harry Little, Ciarán G. O’Connor, Beth Heaslip, Daniel Lawson, Phillip Endicott and Daniel G. Bradley

Author Correction: Lithocholic acid phenocopies anti-ageing effects of calorie restriction pp. E6-E6

Qi Qu, Yan Chen, Yu Wang, Shating Long, Weiche Wang, Heng-Ye Yang, Mengqi Li, Xiao Tian, Xiaoyan Wei, Yan-Hui Liu, Shengrong Xu, Cixiong Zhang, Mingxia Zhu, Sin Man Lam, Jianfeng Wu, Chuyu Yun, Junjie Chen, Shengye Xue, Baoding Zhang, Zhong-Zheng Zheng, Hai-Long Piao, Changtao Jiang, Hao Guo, Guanghou Shui, Xianming Deng, Chen-Song Zhang and Sheng-Cai Lin

Editorial Expression of Concern: Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing pp. E7-E7

Kwok-Kin Wong, Richard S. Maser, Robert M. Bachoo, Jayant Menon, Daniel R. Carrasco, Yansong Gu, Frederick W. Alt and Ronald A. DePinho

‘Male-dominated campuses belong to the past’: the University of Tokyo tackles the gender gap pp. 295-295

Kaori Hayashi

‘It is chaos’: US funding freezes are endangering global health pp. 299-300

Ewen Callaway

How China created AI model DeepSeek and shocked the world pp. 300-301

Gemma Conroy and Smriti Mallapaty

‘High anxiety moment’: Biden’s NIH chief talks Trump 2.0 and the future of US science pp. 302-303

Max Kozlov

The science behind the first pig-organ transplant trial in humans pp. 303-304

Smriti Mallapaty and Max Kozlov

US drug agency approves potent painkiller — the first non-opioid in decades pp. 304-305

Elie Dolgin

Crowds suck people into a vortex — surprising physicists pp. 305-306

Davide Castelvecchi

Thousands of highly cited scientists have at least one retraction pp. 306-306

Jackson Ryan

Dozens of new obesity drugs are coming: these are the ones to watch pp. 308-310

Elie Dolgin

Your brain is full of microplastics: are they harming you? pp. 311-313

Max Kozlov

How to end outrage and detoxify politics: share stories, not statistics pp. 314-315

Leor Zmigrod

Colin Renfrew obituary: archaeologist who shifted thinking on how societies evolve pp. 317-317

Cyprian Broodbank

Japan can be a science heavyweight once more — if it rethinks funding pp. 318-320

Keisuke Goda, Tatsushi Igaki, Bernd Kuhn, Noboru Mizushima, Takeharu Nagai, Atsuhiro Nakagawa, Noriko Osumi, Amy Q. Shen, Masahiro Sonoshita and Masashi Yanagisawa

Close the biodiversity funding gap by teaching conservation to financial professionals pp. 321-321

Xiao Li

Nature markets are nothing new — they are widespread, regulated and instructive pp. 321-321

Siddarth Shrikanth, Sophus zu Ermgassen and Joseph W. Bull

Outdated rules on expenses prevent academics from travelling more sustainably pp. 321-321

Andrea Cardini

Scientific societies need to modernize pp. 321-321

Osvaldo Eric Ramirez-Bravo

The lost long tail of early bird evolution pp. 323-324

Stephen L. Brusatte

Mysterious neutrino barrels through deep waters near Sicily pp. 324-325

Erik K. Blaufuss

Viral tolerance enabled by a bat-specific genomic tweak pp. 326-327

Junji Zhu and Michaela U. Gack

The Greenland Ice Sheet is fracturing faster than expected pp. 327-327

Holly Smith

X-ray telescope casts a sharper gaze on galaxy clusters pp. 328-329

Stefano Borgani

Breaking up clusters of circulating tumour cells to halt cancer spread pp. 329-330

Daniel J. Smit and Klaus Pantel

Signs of damage that drive protein degradation pp. 330-332

Alfred Freeberg and Michael Rapé

The neuroimmune connectome in health and disease pp. 333-342

Michael A. Wheeler and Francisco J. Quintana

Geological Net Zero and the need for disaggregated accounting for carbon sinks pp. 343-350

Myles R. Allen, David J. Frame, Pierre Friedlingstein, Nathan P. Gillett, Giacomo Grassi, Jonathan M. Gregory, William Hare, Jo House, Chris Huntingford, Stuart Jenkins, Chris D. Jones, Reto Knutti, Jason A. Lowe, H. Damon Matthews, Malte Meinshausen, Nicolai Meinshausen, Glen P. Peters, Gian-Kasper Plattner, Sarah Raper, Joeri Rogelj, Peter A. Stott, Susan Solomon, Thomas F. Stocker, Andrew J. Weaver and Kirsten Zickfeld

MorPhiC Consortium: towards functional characterization of all human genes pp. 351-359

Mazhar Adli, Laralynne Przybyla, Tony Burdett, Paul W. Burridge, Pilar Cacheiro, Howard Y. Chang, Jesse M. Engreitz, Luke A. Gilbert, William J. Greenleaf, Li Hsu, Danwei Huangfu, Ling-Hong Hung, Anshul Kundaje, Sheng Li, Helen Parkinson, Xiaojie Qiu, Paul Robson, Stephan C. Schürer, Ali Shojaie, William C. Skarnes, Damian Smedley, Lorenz Studer, Wei Sun, Dušica Vidović, Thomas Vierbuchen, Brian S. White, Ka Yee Yeung, Feng Yue and Ting Zhou

Directly imaging the cooling flow in the Phoenix cluster pp. 360-364

Michael Reefe, Michael McDonald, Marios Chatzikos, Jerome Seebeck, Richard Mushotzky, Sylvain Veilleux, Steven W. Allen, Matthew Bayliss, Michael Calzadilla, Rebecca Canning, Benjamin Floyd, Massimo Gaspari, Julie Hlavacek-Larrondo, Brian McNamara, Helen Russell, Keren Sharon and Taweewat Somboonpanyakul

Millihertz oscillations near the innermost orbit of a supermassive black hole pp. 370-375

Megan Masterson, Erin Kara, Christos Panagiotou, William N. Alston, Joheen Chakraborty, Kevin Burdge, Claudio Ricci, Sibasish Laha, Iair Arcavi, Riccardo Arcodia, S. Bradley Cenko, Andrew C. Fabian, Javier A. García, Margherita Giustini, Adam Ingram, Peter Kosec, Michael Loewenstein, Eileen T. Meyer, Giovanni Miniutti, Ciro Pinto, Ronald A. Remillard, Dev R. Sadaula, Onic I. Shuvo, Benny Trakhtenbrot and Jingyi Wang

Distributed quantum computing across an optical network link pp. 383-388

D. Main, P. Drmota, D. P. Nadlinger, E. M. Ainley, A. Agrawal, B. C. Nichol, R. Srinivas, G. Araneda and D. M. Lucas

Polytype switching by super-lubricant van der Waals cavity arrays pp. 389-393

Youngki Yeo, Yoav Sharaby, Nirmal Roy, Noam Raab, Kenji Watanabe, Takashi Taniguchi and Moshe Ben Shalom

Topological water-wave structures manipulating particles pp. 394-400

Bo Wang, Zhiyuan Che, Cheng Cheng, Caili Tong, Lei Shi, Yijie Shen, Konstantin Y. Bliokh and Jian Zi

H-bonded organic frameworks as ultrasound-programmable delivery platform pp. 401-410

Wenliang Wang, Yanshu Shi, Wenrui Chai, Kai Wing Kevin Tang, Ilya Pyatnitskiy, Yi Xie, Xiangping Liu, Weilong He, Jinmo Jeong, Ju-Chun Hsieh, Anakaren Romero Lozano, Brinkley Artman, Xi Shi, Nicole Hoefer, Binita Shrestha, Noah B. Stern, Wei Zhou, David W. McComb, Tyrone Porter, Graeme Henkelman, Banglin Chen and Huiliang Wang

Two-dimensional polyaniline crystal with metallic out-of-plane conductivity pp. 411-417

Tao Zhang, Shu Chen, Petko St. Petkov, Peng Zhang, Haoyuan Qi, Nguyen Ngan Nguyen, Wenjie Zhang, Jiho Yoon, Peining Li, Thomas Brumme, Alexey Alfonsov, Zhongquan Liao, Mike Hambsch, Shunqi Xu, Lars Mester, Vladislav Kataev, Bernd Büchner, Stefan C. B. Mannsfeld, Ehrenfried Zschech, Stuart S. P. Parkin, Ute Kaiser, Thomas Heine, Renhao Dong, Rainer Hillenbrand and Xinliang Feng

Metal-halide porous framework superlattices pp. 418-424

Wenqiang Zhang, Hong Jiang, Yikuan Liu, Yue Hu, Athulya Surendran Palakkal, Yujie Zhou, Meng Sun, Enping Du, Wei Gong, Qun Zhang, Jianwen Jiang, Jinqiao Dong, Yan Liu, Dehui Li, Yihan Zhu, Yong Cui and Xiangfeng Duan

Transforming US agriculture for carbon removal with enhanced weathering pp. 425-434

David J. Beerling, Euripides P. Kantzas, Mark R. Lomas, Lyla L. Taylor, Shuang Zhang, Yoshiki Kanzaki, Rafael M. Eufrasio, Phil Renforth, Jean-Francois Mecure, Hector Pollitt, Philip B. Holden, Neil R. Edwards, Lenny Koh, Dimitar Z. Epihov, Adam Wolf, James E. Hansen, Steven A. Banwart, Nick F. Pidgeon, Christopher T. Reinhard, Noah J. Planavsky and Maria Val Martin

Meta-analysis reveals global variations in plant diversity effects on productivity pp. 435-440

Chen Chen, Wenya Xiao and Han Y. H. Chen

Earliest short-tailed bird from the Late Jurassic of China pp. 441-448

Runsheng Chen, Min Wang, Liping Dong, Guowu Zhou, Xing Xu, Ke Deng, Liming Xu, Chi Zhang, Linchang Wang, Honggang Du, Ganmin Lin, Min Lin and Zhonghe Zhou

Bat genomes illuminate adaptations to viral tolerance and disease resistance pp. 449-458

Ariadna E. Morales, Yue Dong, Thomas Brown, Kaushal Baid, Dimitrios - Georgios Kontopoulos, Victoria Gonzalez, Zixia Huang, Alexis-Walid Ahmed, Arkadeb Bhuinya, Leon Hilgers, Sylke Winkler, Graham Hughes, Xiaomeng Li, Ping Lu, Yixin Yang, Bogdan M. Kirilenko, Paolo Devanna, Tanya M. Lama, Yomiran Nissan, Martin Pippel, Liliana M. Dávalos, Sonja C. Vernes, Sebastien J. Puechmaille, Stephen J. Rossiter, Yossi Yovel, Joseph B. Prescott, Andreas Kurth, David A. Ray, Burton K. Lim, Eugene Myers, Emma C. Teeling, Arinjay Banerjee, Aaron T. Irving and Michael Hiller

Regional and institutional trends in assessment for academic promotion pp. 459-468

B. H. Lim, C. D’Ippoliti, M. Dominik, A. C. Hernández-Mondragón, K. Vermeir, K. K. Chong, H. Hussein, V. S. Morales-Salgado, K. J. Cloete, J. N. Kimengsi, L. Balboa, S. Mondello, T. E. Cruz, S. Lopez-Verges, I. Sidi Zakari, A. Simonyan, I. Palomo, A. Režek Jambrak, J. Germo Nzweundji, A. Molnar, A. M. I. Saktiawati, S. Elagroudy, P. Kumar, S. Enany, V. Narita, M. Backes, V. Siciliano, D. Egamberdieva and Y. Flores Bueso

Specification of claustro-amygdalar and palaeocortical neurons and circuits pp. 469-478

Navjot Kaur, Rothem Kovner, Forrest O. Gulden, Mihovil Pletikos, David Andrijevic, Tianjia Zhu, John Silbereis, Mikihito Shibata, Akemi Shibata, Yuting Liu, Shaojie Ma, Nikkita Salla, Xabier Martin, Thomas S. Klarić, Megan Burke, Daniel Franjic, Hyesun Cho, Matthew Yuen, Ipsita Chatterjee, Paula Soric, Devippriya Esakkimuthu, Markus Moser, Gabriel Santpere, Yann S. Mineur, Kartik Pattabiraman, Marina R. Picciotto, Hao Huang and Nenad Sestan

Cationic peptides cause memory loss through endophilin-mediated endocytosis pp. 479-489

Eric G. Stokes, Jose J. Vasquez, Ghalia Azouz, Megan Nguyen, Alexa Tierno, Yinyin Zhuang, Vivienne Mae Galinato, May Hui, Michael Toledano, Isabella Tyler, Xiaoyu Shi, Robert F. Hunt, Jason Aoto and Kevin T. Beier

GZMK-expressing CD8+ T cells promote recurrent airway inflammatory diseases pp. 490-498

Feng Lan, Jizhou Li, Wenxuan Miao, Fei Sun, Su Duan, Yabing Song, Jiacheng Yao, Xiangdong Wang, Chengshuo Wang, Xin Liu, Jianbin Wang, Luo Zhang and Hai Qi

Gliomagenesis mimics an injury response orchestrated by neural crest-like cells pp. 499-509

Akram A. Hamed, Kui Hua, Quang M. Trinh, Benjamin D. Simons, John C. Marioni, Lincoln D. Stein and Peter B. Dirks

Complex rearrangements fuel ER+ and HER2+ breast tumours pp. 510-518

Kathleen E. Houlahan, Lise Mangiante, Cristina Sotomayor-Vivas, Alvina Adimoelja, Seongyeol Park, Aziz Khan, Sophia J. Pribus, Zhicheng Ma, Jennifer L. Caswell-Jin and Christina Curtis

C-terminal amides mark proteins for degradation via SCF–FBXO31 pp. 519-527

Matthias F. Muhar, Jakob Farnung, Martina Cernakova, Raphael Hofmann, Lukas T. Henneberg, Moritz M. Pfleiderer, Annina Denoth-Lippuner, Filip Kalčic, Ajse S. Nievergelt, Marwa Peters Al-Bayati, Nikolaos D. Sidiropoulos, Viola Beier, Matthias Mann, Sebastian Jessberger, Martin Jinek, Brenda A. Schulman, Jeffrey W. Bode and Jacob E. Corn

Functional evaluation and clinical classification of BRCA2 variants pp. 528-537

Huaizhi Huang, Chunling Hu, Jie Na, Steven N. Hart, Rohan David Gnanaolivu, Mohamed Abozaid, Tara Rao, Yohannes A. Tecleab, Tina Pesaran, Paulo Cilas Morais Lyra, Rachid Karam, Siddhartha Yadav, Katherine L. Nathanson, Susan M. Domchek, Miguel Hoya, Mark Robson, Miika Mehine, Chaitanya Bandlamudi, Diana Mandelker, Alvaro N. A. Monteiro, Edwin S. Iversen, Nicholas Boddicker, Wenan Chen, Marcy E. Richardson and Fergus J. Couch

Saturation genome editing-based clinical classification of BRCA2 variants pp. 538-545

Sounak Sahu, Melissa Galloux, Eileen Southon, Dylan Caylor, Teresa Sullivan, Matteo Arnaudi, Maria Zanti, Josephine Geh, Raj Chari, Kyriaki Michailidou, Elena Papaleo and Shyam K. Sharan

Four-component protein nanocages designed by programmed symmetry breaking pp. 546-552

Sangmin Lee, Ryan D. Kibler, Green Ahn, Yang Hsia, Andrew J. Borst, Annika Philomin, Madison A. Kennedy, Buwei Huang, Barry Stoddard and David Baker

Hierarchical design of pseudosymmetric protein nanocages pp. 553-561

Quinton M. Dowling, Young-Jun Park, Chelsea N. Fries, Neil C. Gerstenmaier, Sebastian Ols, Erin C. Yang, Adam J. Wargacki, Annie Dosey, Yang Hsia, Rashmi Ravichandran, Carl D. Walkey, Anika L. Burrell, David Veesler, David Baker and Neil P. King

Resolving native GABAA receptor structures from the human brain pp. 562-568

Jia Zhou, Colleen M. Noviello, Jinfeng Teng, Haley Moore, Bradley Lega and Ryan E. Hibbs

How hosting Ukrainian scientists offers a template for supporting other scholars at risk pp. 569-571

Benjamin Plackett

I grow medicinal mushrooms in my renewable-energy laboratory pp. 574-574

Gemma Conroy

2025, volume 638, articles 8049

Author Correction: R-loop-dependent promoter-proximal termination ensures genome stability pp. E1-E1

Congling Xu, Chengyu Li, Jiwei Chen, Yan Xiong, Zhibin Qiao, Pengyu Fan, Conghui Li, Shuangyu Ma, Jin Liu, Aixia Song, Bolin Tao, Tao Xu, Wei Xu, Yayun Chi, Jingyan Xue, Pu Wang, Dan Ye, Hongzhou Gu, Peng Zhang, Qiong Wang, Ruijing Xiao, Jingdong Cheng, Hai Zheng, Xiaoli Yu, Zhen Zhang, Jiong Wu, Kaiwei Liang, Yan-Jun Liu, Huasong Lu and Fei Xavier Chen

‘Despair is not an option’ — how scientists can help protect federal research pp. 9-9

Gretchen T. Goldman

China’s cheap, open AI model DeepSeek thrills scientists pp. 13-14

Elizabeth Gibney

What went wrong at 23andMe? Why the genetic-data giant risks collapse pp. 14-15

Diana Kwon

Will bird flu spark a human pandemic? Scientists say the risk is rising pp. 16-17

Max Kozlov

Extreme heat will kill millions of people in Europe without rapid action pp. 17-18

Humberto Basilio

‘Breakthrough’ stem-cell patches strengthened a woman’s failing heart pp. 18-18

Miryam Naddaf

Four lessons COVID taught us about the immune system pp. 19-20

Heidi Ledford

Microplastics block blood flow in the brain, mouse study reveals pp. 20-20

Smriti Mallapaty

Can this revolutionary plastics-recycling plant help solve the pollution crisis? pp. 22-25

Mark Peplow

Are the Internet and AI affecting our memory? What the science says pp. 26-28

Helen Pearson

‘Taung Child’ fossil offers clues about the evolution of childhood pp. 29-31

Dean Falk

Why even physicists still don’t understand quantum theory 100 years on pp. 31-34

Sean Carroll

NASA’s ‘most prolific planet hunter so far’ — the story of the Kepler Space Telescope pp. 34-36

Elizabeth Tasker

Can you ever experience true silence? Intimate exhibition offers insight pp. 36-37

Laura Spinney

James Fraser Stoddart obituary: chemist and nanotechnology pioneer who built molecular machines pp. 38-38

David A. Leigh

The world must move forwards with plastics treaty pp. 39-39

Chengjun Li and Huan Zhong

Guerilla rewilding undermines evidence-based conservation pp. 39-39

Chris Sutherland, Xavier Lambin, Darragh Hare and Kenny Kortland

Net-zero emissions commitments are more threatened than ever pp. 39-39

Cássio Cardoso Pereira

Report both positive and negative effects of gene changes on crops pp. 39-39

Shujun Meng, Guan Zhang and Qingyu Wu

Crowds start to spin when their densities hit a threshold pp. 41-42

Antoine Tordeux

Mitochondrial swap from cancer to immune cells thwarts anti-tumour defences pp. 42-43

Jonathan R. Brestoff

‘Unconventional’ superconductivity probed in twisted graphene pp. 44-45

Paritosh Karnatak and Christian Schönenberger

X chromosome passed from mother to daughter influences brain ageing pp. 45-47

Daniel M. Snell and James M. A. Turner

A scalable system using mini-organs to test personalized RNA therapy pp. 47-48

Ronald A. M. Buijsen

Fungal impacts on Earth’s ecosystems pp. 49-57

Nicola T. Case, Sarah J. Gurr, Matthew C. Fisher, David S. Blehert, Charles Boone, Arturo Casadevall, Anuradha Chowdhary, Christina A. Cuomo, Cameron R. Currie, David W. Denning, Iuliana V. Ene, Lillian K. Fritz-Laylin, Aleeza C. Gerstein, Neil A. R. Gow, Asiya Gusa, Iliyan D. Iliev, Timothy Y. James, Hailing Jin, Regine Kahmann, Bruce S. Klein, James W. Kronstad, Kyla S. Ost, Kabir G. Peay, Rebecca S. Shapiro, Donald C. Sheppard, Neta Shlezinger, Jason E. Stajich, Eva H. Stukenbrock, John W. Taylor, Gerard D. Wright, Leah E. Cowen, Joseph Heitman and Julia A. Segre

Two-Eyed Seeing and other Indigenous perspectives for neuroscience pp. 58-68

J. Illes, M. L. Perreault, K. Bassil, J. G. Bjaalie, R. L. Taylor-Bragge, H. Chneiweiss, T. R. Gregory, B. N. Kumar, O. P. Matshabane, A. L. Svalastog and M. R. Velarde

Io’s tidal response precludes a shallow magma ocean pp. 69-73

R. S. Park, R. A. Jacobson, L. Gomez Casajus, F. Nimmo, A. I. Ermakov, J. T. Keane, W. B. McKinnon, D. J. Stevenson, R. Akiba, B. Idini, D. R. Buccino, A. Magnanini, M. Parisi, P. Tortora, M. Zannoni, A. Mura, D. Durante, L. Iess, J. E. P. Connerney, S. M. Levin and S. J. Bolton

JWST sighting of decametre main-belt asteroids and view on meteorite sources pp. 74-78

Artem Y. Burdanov, Julien Wit, Miroslav Brož, Thomas G. Müller, Tobias Hoffmann, Marin Ferrais, Marco Micheli, Emmanuel Jehin, Daniel Parrott, Samantha N. Hasler, Richard P. Binzel, Elsa Ducrot, Laura Kreidberg, Michaël Gillon, Thomas P. Greene, Will M. Grundy, Theodore Kareta, Pierre-Olivier Lagage, Nicholas Moskovitz, Audrey Thirouin, Cristina A. Thomas and Sebastian Zieba

Thermalization and criticality on an analogue–digital quantum simulator pp. 79-85

T. I. Andersen, N. Astrakhantsev, A. H. Karamlou, J. Berndtsson, J. Motruk, A. Szasz, J. A. Gross, A. Schuckert, T. Westerhout, Y. Zhang, E. Forati, D. Rossi, B. Kobrin, A. Di Paolo, A. R. Klots, I. Drozdov, V. Kurilovich, A. Petukhov, L. B. Ioffe, A. Elben, A. Rath, V. Vitale, B. Vermersch, R. Acharya, L. A. Beni, K. Anderson, M. Ansmann, F. Arute, K. Arya, A. Asfaw, J. Atalaya, B. Ballard, J. C. Bardin, A. Bengtsson, A. Bilmes, G. Bortoli, A. Bourassa, J. Bovaird, L. Brill, M. Broughton, D. A. Browne, B. Buchea, B. B. Buckley, D. A. Buell, T. Burger, B. Burkett, N. Bushnell, A. Cabrera, J. Campero, H.-S. Chang, Z. Chen, B. Chiaro, J. Claes, A. Y. Cleland, J. Cogan, R. Collins, P. Conner, W. Courtney, A. L. Crook, S. Das, D. M. Debroy, L. De Lorenzo, A. Del Toro Barba, S. Demura, P. Donohoe, A. Dunsworth, C. Earle, A. Eickbusch, A. M. Elbag, M. Elzouka, C. Erickson, L. Faoro, R. Fatemi, V. S. Ferreira, L. Flores Burgos, A. G. Fowler, B. Foxen, S. Ganjam, R. Gasca, W. Giang, C. Gidney, D. Gilboa, M. Giustina, R. Gosula, A. Grajales Dau, D. Graumann, A. Greene, S. Habegger, M. C. Hamilton, M. Hansen, M. P. Harrigan, S. D. Harrington, S. Heslin, P. Heu, G. Hill, M. R. Hoffmann, H.-Y. Huang, T. Huang, A. Huff, W. J. Huggins, S. V. Isakov, E. Jeffrey, Z. Jiang, C. Jones, S. Jordan, C. Joshi, P. Juhas, D. Kafri, H. Kang, K. Kechedzhi, T. Khaire, T. Khattar, M. Khezri, M. Kieferová, S. Kim, A. Kitaev, P. Klimov, A. N. Korotkov, F. Kostritsa, J. M. Kreikebaum, D. Landhuis, B. W. Langley, P. Laptev, K.-M. Lau, L. Le Guevel, J. Ledford, J. Lee, K. W. Lee, Y. D. Lensky, B. J. Lester, W. Y. Li, A. T. Lill, W. Liu, W. P. Livingston, A. Locharla, D. Lundahl, A. Lunt, S. Madhuk, A. Maloney, S. Mandrà, L. S. Martin, O. Martin, S. Martin, C. Maxfield, J. R. McClean, M. McEwen, S. Meeks, K. C. Miao, A. Mieszala, S. Molina, S. Montazeri, A. Morvan, R. Movassagh, C. Neill, A. Nersisyan, M. Newman, A. Nguyen, M. Nguyen, C.-H. Ni, M. Y. Niu, W. D. Oliver, K. Ottosson, A. Pizzuto, R. Potter, O. Pritchard, L. P. Pryadko, C. Quintana, M. J. Reagor, D. M. Rhodes, G. Roberts, C. Rocque, E. Rosenberg, N. C. Rubin, N. Saei, K. Sankaragomathi, K. J. Satzinger, H. F. Schurkus, C. Schuster, M. J. Shearn, A. Shorter, N. Shutty, V. Shvarts, V. Sivak, J. Skruzny, S. Small, W. Clarke Smith, S. Springer, G. Sterling, J. Suchard, M. Szalay, A. Sztein, D. Thor, A. Torres, M. M. Torunbalci, A. Vaishnav, S. Vdovichev, B. Villalonga, C. Vollgraff Heidweiller, S. Waltman, S. X. Wang, T. White, K. Wong, B. W. K. Woo, C. Xing, Z. Jamie Yao, P. Yeh, B. Ying, J. Yoo, N. Yosri, G. Young, A. Zalcman, N. Zhu, N. Zobrist, H. Neven, R. Babbush, S. Boixo, J. Hilton, E. Lucero, A. Megrant, J. Kelly, Y. Chen, V. Smelyanskiy, G. Vidal, P. Roushan, A. M. Läuchli, D. A. Abanin and X. Mi

Quantum coarsening and collective dynamics on a programmable simulator pp. 86-92

Tom Manovitz, Sophie H. Li, Sepehr Ebadi, Rhine Samajdar, Alexandra A. Geim, Simon J. Evered, Dolev Bluvstein, Hengyun Zhou, Nazli Ugur Koyluoglu, Johannes Feldmeier, Pavel E. Dolgirev, Nishad Maskara, Marcin Kalinowski, Subir Sachdev, David A. Huse, Markus Greiner, Vladan Vuletić and Mikhail D. Lukin

Superfluid stiffness of twisted trilayer graphene superconductors pp. 93-98

Abhishek Banerjee, Zeyu Hao, Mary Kreidel, Patrick Ledwith, Isabelle Phinney, Jeong Min Park, Andrew Zimmerman, Marie E. Wesson, Kenji Watanabe, Takashi Taniguchi, Robert M. Westervelt, Amir Yacoby, Pablo Jarillo-Herrero, Pavel A. Volkov, Ashvin Vishwanath, Kin Chung Fong and Philip Kim

Superfluid stiffness of magic-angle twisted bilayer graphene pp. 99-105

Miuko Tanaka, Joel Î-j. Wang, Thao H. Dinh, Daniel Rodan-Legrain, Sameia Zaman, Max Hays, Aziza Almanakly, Bharath Kannan, David K. Kim, Bethany M. Niedzielski, Kyle Serniak, Mollie E. Schwartz, Kenji Watanabe, Takashi Taniguchi, Terry P. Orlando, Simon Gustavsson, Jeffrey A. Grover, Pablo Jarillo-Herrero and William D. Oliver

Signatures of longitudinal spin pumping in a magnetic phase transition pp. 106-111

Taekhyeon Lee, Min Tae Park, Hye-Won Ko, Jung Hyun Oh, San Ko, Seongmun Hwang, Jae Gwang Jang, Geon-Woo Baek, Se Kwon Kim, Hyun-Woo Lee, Myung-Hwa Jung, Kab-Jin Kim and Kyung-Jin Lee

Emergence of collective oscillations in massive human crowds pp. 112-119

François Gu, Benjamin Guiselin, Nicolas Bain, Iker Zuriguel and Denis Bartolo

Degradable thermosets via orthogonal polymerizations of a single monomer pp. 120-125

Reagan J. Dreiling, Kathleen Huynh and Brett P. Fors

Copper-dependent halogenase catalyses unactivated C−H bond functionalization pp. 126-132

Chen-Yu Chiang, Masao Ohashi, Jessie Le, Pan-Pan Chen, Qingyang Zhou, Songrong Qu, Undramaa Bat-Erdene, Shabnam Hematian, Jose A. Rodriguez, K. N. Houk, Yisong Guo, Joseph A. Loo and Yi Tang

The Ronne Ice Shelf survived the last interglacial pp. 133-137

Eric W. Wolff, Robert Mulvaney, Mackenzie M. Grieman, Helene M. Hoffmann, Jack Humby, Christoph Nehrbass-Ahles, Rachael H. Rhodes, Isobel F. Rowell, Louise C. Sime, Hubertus Fischer, Thomas F. Stocker, Amaelle Landais, Frédéric Parrenin, Eric J. Steig, Marina Dütsch and Nicholas R. Golledge

One-quarter of freshwater fauna threatened with extinction pp. 138-145

Catherine A. Sayer, Eresha Fernando, Randall R. Jimenez, Nicholas B. W. Macfarlane, Giovanni Rapacciuolo, Monika Böhm, Thomas M. Brooks, Topiltzin Contreras-MacBeath, Neil A. Cox, Ian Harrison, Michael Hoffmann, Richard Jenkins, Kevin G. Smith, Jean-Christophe Vié, John C. Abbott, David J. Allen, Gerald R. Allen, Violeta Barrios, Jean-Pierre Boudot, Savrina F. Carrizo, Patricia Charvet, Viola Clausnitzer, Leonardo Congiu, Keith A. Crandall, Neil Cumberlidge, Annabelle Cuttelod, James Dalton, Adam G. Daniels, Sammy Grave, Geert Knijf, Klaas-Douwe B. Dijkstra, Rory A. Dow, Jörg Freyhof, Nieves García, Joern Gessner, Abebe Getahun, Claudine Gibson, Matthew J. Gollock, Michael I. Grant, Alice E. R. Groom, Michael P. Hammer, Geoffrey A. Hammerson, Craig Hilton-Taylor, Laurel Hodgkinson, Robert A. Holland, Rima W. Jabado, Diego Juffe Bignoli, Vincent J. Kalkman, Bakhtiyor K. Karimov, Jens Kipping, Maurice Kottelat, Philippe A. Lalèyè, Helen K. Larson, Mark Lintermans, Federico Lozano, Arne Ludwig, Timothy J. Lyons, Laura Máiz-Tomé, Sanjay Molur, Heok Hee Ng, Catherine Numa, Amy F. Palmer-Newton, Charlotte Pike, Helen E. Pippard, Carla N. M. Polaz, Caroline M. Pollock, Rajeev Raghavan, Peter S. Rand, Tsilavina Ravelomanana, Roberto E. Reis, Cassandra L. Rigby, Janet A. Scott, Paul H. Skelton, Matthew R. Sloat, Jos Snoeks, Melanie L. J. Stiassny, Heok Hui Tan, Yoshinori Taniguchi, Eva B. Thorstad, Marcelo F. Tognelli, Armi G. Torres, Yan Torres, Denis Tweddle, Katsutoshi Watanabe, James R. S. Westrip, Emma G. E. Wright, E Zhang and William R. T. Darwall

Cretaceous Antarctic bird skull elucidates early avian ecological diversity pp. 146-151

Christopher R. Torres, Julia A. Clarke, Joseph R. Groenke, Matthew C. Lamanna, Ross D. E. MacPhee, Grace M. Musser, Eric M. Roberts and Patrick M. O’Connor

The maternal X chromosome affects cognition and brain ageing in female mice pp. 152-159

Samira Abdulai-Saiku, Shweta Gupta, Dan Wang, Francesca Marino, Arturo J. Moreno, Yu Huang, Deepak Srivastava, Barbara Panning and Dena B. Dubal

Spatial transcriptomic clocks reveal cell proximity effects in brain ageing pp. 160-171

Eric D. Sun, Olivia Y. Zhou, Max Hauptschein, Nimrod Rappoport, Lucy Xu, Paloma Navarro Negredo, Ling Liu, Thomas A. Rando, James Zou and Anne Brunet

Dysregulation of mTOR signalling is a converging mechanism in lissencephaly pp. 172-181

Ce Zhang, Dan Liang, A. Gulhan Ercan-Sencicek, Aybike S. Bulut, Joelly Cortes, Iris Q. Cheng, Octavian Henegariu, Sayoko Nishimura, Xinyuan Wang, A. Buket Peksen, Yutaka Takeo, Caner Caglar, TuKiet T. Lam, Merve Nur Koroglu, Anand Narayanan, Francesc Lopez-Giraldez, Danielle F. Miyagishima, Ketu Mishra-Gorur, Tanyeri Barak, Katsuhito Yasuno, E. Zeynep Erson-Omay, Cengiz Yalcinkaya, Guilin Wang, Shrikant Mane, Hande Kaymakcalan, Aslan Guzel, A. Okay Caglayan, Beyhan Tuysuz, Nenad Sestan, Murat Gunel, Angeliki Louvi and Kaya Bilguvar

Brain-wide cell-type-specific transcriptomic signatures of healthy ageing in mice pp. 182-196

Kelly Jin, Zizhen Yao, Cindy T. J. Velthoven, Eitan S. Kaplan, Katie Glattfelder, Samuel T. Barlow, Gabriella Boyer, Daniel Carey, Tamara Casper, Anish Bhaswanth Chakka, Rushil Chakrabarty, Michael Clark, Max Departee, Marie Desierto, Amanda Gary, Jessica Gloe, Jeff Goldy, Nathan Guilford, Junitta Guzman, Daniel Hirschstein, Changkyu Lee, Elizabeth Liang, Trangthanh Pham, Melissa Reding, Kara Ronellenfitch, Augustin Ruiz, Josh Sevigny, Nadiya Shapovalova, Lyudmila Shulga, Josef Sulc, Amy Torkelson, Herman Tung, Boaz Levi, Susan M. Sunkin, Nick Dee, Luke Esposito, Kimberly A. Smith, Bosiljka Tasic and Hongkui Zeng

A rare PRIMER cell state in plant immunity pp. 197-205

Tatsuya Nobori, Alexander Monell, Travis A. Lee, Yuka Sakata, Shoma Shirahama, Jingtian Zhou, Joseph R. Nery, Akira Mine and Joseph R. Ecker

Bone marrow niches orchestrate stem-cell hierarchy and immune tolerance pp. 206-215

Kazuhiro Furuhashi, Miwako Kakiuchi, Ryosuke Ueda, Hiroko Oda, Simone Ummarino, Alexander K. Ebralidze, Mahmoud A. Bassal, Chen Meng, Tatsuyuki Sato, Jing Lyu, Min-guk Han, Shoichi Maruyama, Yu Watanabe, Yuriko Sawa, Daisuke Kato, Hiroaki Wake, Boris Reizis, John A. Frangos, David M. Owens, Daniel G. Tenen, Ionita C. Ghiran, Simon C. Robson and Joji Fujisaki

Host metabolism balances microbial regulation of bile acid signalling pp. 216-224

Tae Hyung Won, Mohammad Arifuzzaman, Christopher N. Parkhurst, Isabella C. Miranda, Bingsen Zhang, Elin Hu, Sanchita Kashyap, Jeffrey Letourneau, Wen-Bing Jin, Yousi Fu, Douglas V. Guzior, Robert A. Quinn, Chun-Jun Guo, Lawrence A. David, David Artis and Frank C. Schroeder

Immune evasion through mitochondrial transfer in the tumour microenvironment pp. 225-236

Hideki Ikeda, Katsushige Kawase, Tatsuya Nishi, Tomofumi Watanabe, Keizo Takenaga, Takashi Inozume, Takamasa Ishino, Sho Aki, Jason Lin, Shusuke Kawashima, Joji Nagasaki, Youki Ueda, Shinichiro Suzuki, Hideki Makinoshima, Makiko Itami, Yuki Nakamura, Yasutoshi Tatsumi, Yusuke Suenaga, Takao Morinaga, Akiko Honobe-Tabuchi, Takehiro Ohnuma, Tatsuyoshi Kawamura, Yoshiyasu Umeda, Yasuhiro Nakamura, Yukiko Kiniwa, Eiki Ichihara, Hidetoshi Hayashi, Jun-ichiro Ikeda, Toyoyuki Hanazawa, Shinichi Toyooka, Hiroyuki Mano, Takuji Suzuki, Tsuyoshi Osawa, Masahito Kawazu and Yosuke Togashi

Rapid and scalable personalized ASO screening in patient-derived organoids pp. 237-243

John C. Means, Anabel L. Martinez-Bengochea, Daniel A. Louiselle, Jacqelyn M. Nemechek, John M. Perry, Emily G. Farrow, Tomi Pastinen and Scott T. Younger

Aspartate signalling drives lung metastasis via alternative translation pp. 244-250

Ginevra Doglioni, Juan Fernández-García, Sebastian Igelmann, Patricia Altea-Manzano, Arnaud Blomme, Rita Rovere, Xiao-Zheng Liu, Yawen Liu, Tine Tricot, Max Nobis, Ning An, Marine Leclercq, Sarah El Kharraz, Panagiotis Karras, Yu-Heng Hsieh, Fiorella A. Solari, Luiza Martins Nascentes Melo, Gabrielle Allies, Annalisa Scopelliti, Matteo Rossi, Ines Vermeire, Dorien Broekaert, Ana Margarida Ferreira Campos, Patrick Neven, Marion Maetens, Karen Baelen, H. Furkan Alkan, Mélanie Planque, Giuseppe Floris, Albert Sickmann, Alpaslan Tasdogan, Jean-Christophe Marine, Colinda L. G. J. Scheele, Christine Desmedt, Geert Bultynck, Pierre Close and Sarah-Maria Fendt

Nucleosome fibre topology guides transcription factor binding to enhancers pp. 251-260

Michael R. O’Dwyer, Meir Azagury, Katharine Furlong, Amani Alsheikh, Elisa Hall-Ponsele, Hugo Pinto, Dmitry V. Fyodorov, Mohammad Jaber, Eleni Papachristoforou, Hana Benchetrit, James Ashmore, Kirill Makedonski, Moran Rahamim, Marta Hanzevacki, Hazar Yassen, Samuel Skoda, Adi Levy, Steven M. Pollard, Arthur I. Skoultchi, Yosef Buganim and Abdenour Soufi

Crosslinking intermodular condensation in non-ribosomal peptide biosynthesis pp. 261-269

Graham W. Heberlig, James J. Clair and Michael D. Burkart

Structures and mechanism of condensation in non-ribosomal peptide synthesis pp. 270-278

Angelos Pistofidis, Pengchen Ma, Zihao Li, Kim Munro, K. N. Houk and T. Martin Schmeing

‘Research that touches the heart’: the scientists who study sex and love pp. 279-281

Emily Sohn

Microbes in space: how bacteria could help sustain long-distance space travel pp. 282-284

Amber Dance

Researching endangered animals in the Sahara has its own dangers pp. 286-286

Christine Ro