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2025, volume 643, articles 8074

Protect the integrity of the US National Institutes of Health pp. 1191-1191

Kevin C. Kent Lloyd, Karen C. Johnston and Barbara Kelley

2025, volume 643, articles 8073

Experiments implementing small commuting models lack gravitational features pp. E17-E19

Bryce Kobrin, Thomas Schuster and Norman Y. Yao

Reply to: Experiments implementing small commuting models lack gravitational features pp. E20-E23

Daniel Jafferis, Alexander Zlokapa, Joseph D. Lykken, David K. Kolchmeyer, Samantha I. Davis, Hartmut Neven and Maria Spiropulu

Author Correction: Adipose tissue retains an epigenetic memory of obesity after weight loss pp. E24-E24

Laura C. Hinte, Daniel Castellano-Castillo, Adhideb Ghosh, Kate Melrose, Emanuel Gasser, Falko Noé, Lucas Massier, Hua Dong, Wenfei Sun, Anne Hoffmann, Christian Wolfrum, Mikael Rydén, Niklas Mejhert, Matthias Blüher and Ferdinand von Meyenn

Fund scholars who tackle urgent issues — from misinformation to error spotting pp. 881-881

James Smoliga

US senators poised to reject Trump’s proposed massive science cuts pp. 885-886

Dan Garisto and Alexandra Witze

Scientists hide messages in papers to game AI peer review pp. 887-888

Elizabeth Gibney

Monster black hole merger is biggest ever seen pp. 888-889

Jonathan O’Callaghan

‘Another DeepSeek moment’: Chinese AI model Kimi K2 stirs excitement pp. 889-890

Elizabeth Gibney

Birth of a solar system caught ‘on camera’ for first time pp. 890-890

Jenna Ahart

‘Landmark’ study: three-person IVF leads to eight healthy children pp. 891-891

Ewen Callaway

Mini hearts, lungs and livers made in lab now grow their own blood vessels pp. 892-892

Smriti Mallapaty

There’s a new acid in our rain — should we be worried? pp. 894-897

XiaoZhi Lim

How to avoid nuclear war in an era of AI and misinformation pp. 898-900

Alexandra Witze

Should we treat rivers as living things? pp. 901-903

Andrew Robinson

‘Controlled chaos’: how to create an environment that fosters genius pp. 903-905

Patrick Maynard

Rise of the planet of the zombie bugs: Books in brief pp. 905-905

Andrew Robinson

China’s fossil-fuel challenge — how to build a bridge to renewables pp. 907-910

Yihe Xu

Why evaluating the impact of AI needs to start now pp. 910-912

Oliver P. Hauser, Miriam Light, Lizzie Shelmerdine and Jack Blumenau

Scientists everywhere must be protected pp. 913-913

Ali Meghdari

Why publishing referee reports could backfire on public trust pp. 913-913

Ramit Debnath, R. Michael Alvarez and Danny Ebanks

Encouraging a ‘data sufficiency’ mindset is key for responsible research pp. 913-913

Alexandre Heeren

Brazil must not weaken environmental planning rules pp. 913-913

Jean Paul Metzger, Gabriela Marques di Giulio, Letícia Veras Costa-Lotufo and Simone Aparecida Vieira

Migratory moths navigate using the stars pp. 915-916

Kenneth J. Lohmann

Scientific jargon can be ‘satisfying’ — but misleading pp. 916-917

Todd Rogers and Hillary Shulman

Solid gold superheated to 14 times its melting temperature pp. 917-918

Artur Tamm

‘Place’ neurons recognize the same spot from close by and far away pp. 919-920

Uwe Mayer

Boys surpass girls in maths in the first year of school pp. 920-921

John A. List and Andrew Simon

Solving aviation’s climate-action conundrum pp. 921-923

Christiane Voigt

Integrated biotechnological and AI innovations for crop improvement pp. 925-937

Guotian Li, Linna An, Wanneng Yang, Lei Yang, Tong Wei, Jiawei Shi, Jianglin Wang, John H. Doonan, Kabin Xie, Alisdair R. Fernie, Evans S. Lagudah, Rod A. Wing and Caixia Gao

Silicate clouds and a circumplanetary disk in the YSES-1 exoplanet system pp. 938-942

K. K. W. Hoch, M. Rowland, S. Petrus, E. Nasedkin, C. Ingebretsen, J. Kammerer, M. Perrin, V. D’Orazi, W. O. Balmer, T. Barman, M. Bonnefoy, G. Chauvin, C. Chen, R. J. De Rosa, J. Girard, E. Gonzales, M. Kenworthy, Q. M. Konopacky, B. Macintosh, S. E. Moran, C. V. Morley, P. Palma-Bifani, L. Pueyo, B. Ren, E. Rickman, J.-B. Ruffio, C. A. Theissen, K. Ward-Duong and Y. Zhang

Single nuclear spin detection and control in a van der Waals material pp. 943-949

Xingyu Gao, Sumukh Vaidya, Kejun Li, Zhun Ge, Saakshi Dikshit, Shimin Zhang, Peng Ju, Kunhong Shen, Yuanbin Jin, Yuan Ping and Tongcang Li

Superheating gold beyond the predicted entropy catastrophe threshold pp. 950-954

Thomas G. White, Travis D. Griffin, Daniel Haden, Hae Ja Lee, Eric Galtier, Eric Cunningham, Dimitri Khaghani, Adrien Descamps, Lennart Wollenweber, Ben Armentrout, Carson Convery, Karen Appel, Luke B. Fletcher, Sebastian Goede, J. B. Hastings, Jeremy Iratcabal, Emma E. McBride, Jacob Molina, Giulio Monaco, Landon Morrison, Hunter Stramel, Sameen Yunus, Ulf Zastrau, Siegfried H. Glenzer, Gianluca Gregori, Dirk O. Gericke and Bob Nagler

Hybrid quantum network for sensing in the acoustic frequency range pp. 955-960

Valeriy Novikov, Jun Jia, Túlio Brito Brasil, Andrea Grimaldi, Maïmouna Bocoum, Mikhail Balabas, Jörg Helge Müller, Emil Zeuthen and Eugene Simon Polzik

Synthesis of deuterated acids and bases using bipolar membranes pp. 961-966

Junying Yan, Chenxiao Jiang, Xiongzhi Zeng, Wanjie Song, Jie Yang, Xiaolin Ge, Liang Wu, Zhengjin Yang, Zhenyu Li, Yaoming Wang and Tongwen Xu

Stereodivergent transformation of a natural polyester to enantiopure PHAs pp. 967-974

Jun-Jie Tian, Ruirui Li, Ethan C. Quinn, Jiyun Nam, Eswara Rao Chokkapu, Zhen Zhang, Li Zhou, Ravikumar R. Gowda and Eugene Y.-X. Chen

Boron-mediated modular assembly of tetrasubstituted alkenes pp. 975-982

Liang Wei, Mihai V. Popescu, Adam Noble, Robert S. Paton and Varinder K. Aggarwal

Decadal changes in atmospheric circulation detected in cloud motion vectors pp. 983-987

Larry Di Girolamo, Guangyu Zhao, Gan Zhang, Zhuo Wang, Jesse Loveridge and Arka Mitra

Trade-offs in aviation impacts on climate favour non-CO2 mitigation pp. 988-993

Michael J. Prather, Andrew Gettelman and Joyce E. Penner

Bogong moths use a stellar compass for long-distance navigation at night pp. 994-1000

David Dreyer, Andrea Adden, Hui Chen, Barrie Frost, Henrik Mouritsen, Jingjing Xu, Ken Green, Mary Whitehouse, Javaan Chahl, Jesse Wallace, Gao Hu, James Foster, Stanley Heinze and Eric Warrant

Domesticated cannabinoid synthases amid a wild mosaic cannabis pangenome pp. 1001-1010

Ryan C. Lynch, Lillian K. Padgitt-Cobb, Andrea R. Garfinkel, Brian J. Knaus, Nolan T. Hartwick, Nicholas Allsing, Anthony Aylward, Philip C. Bentz, Sarah B. Carey, Allen Mamerto, Justine K. Kitony, Kelly Colt, Emily R. Murray, Tiffany Duong, Heidi I. Chen, Aaron Trippe, Alex Harkess, Seth Crawford, Kelly Vining and Todd P. Michael

The spatiotemporal distribution of human pathogens in ancient Eurasia pp. 1011-1019

Martin Sikora, Elisabetta Canteri, Antonio Fernandez-Guerra, Nikolay Oskolkov, Rasmus Ågren, Lena Hansson, Evan K. Irving-Pease, Barbara Mühlemann, Sofie Holtsmark Nielsen, Gabriele Scorrano, Morten E. Allentoft, Frederik Valeur Seersholm, Hannes Schroeder, Charleen Gaunitz, Jesper Stenderup, Lasse Vinner, Terry C. Jones, Björn Nystedt, Karl-Göran Sjögren, Julian Parkhill, Lars Fugger, Fernando Racimo, Kristian Kristiansen, Astrid K. N. Iversen and Eske Willerslev

Rapid emergence of a maths gender gap in first grade pp. 1020-1029

P. Martinot, B. Colnet, T. Breda, J. Sultan, L. Touitou, P. Huguet, E. Spelke, G. Dehaene-Lambertz, P. Bressoux and S. Dehaene

Closed-loop vagus nerve stimulation aids recovery from spinal cord injury pp. 1030-1036

Michael P. Kilgard, Joseph D. Epperson, Emmanuel A. Adehunoluwa, Chad Swank, Amy L. Porter, David T. Pruitt, Holle L. Gallaway, Christi Stevens, Jaime Gillespie, Dannae Arnold, Mark B. Powers, Rita G. Hamilton, Richard C. Naftalis, Michael L. Foreman, Jane G. Wigginton, Seth A. Hays and Robert L. Rennaker

Remote activation of place codes by gaze in a highly visual animal pp. 1037-1043

Hannah L. Payne and Dmitriy Aronov

Prefrontal encoding of an internal model for emotional inference pp. 1044-1056

Xiaowei Gu and Joshua P. Johansen

CoQ imbalance drives reverse electron transport to disrupt liver metabolism pp. 1057-1065

Renata L. S. Goncalves, Zeqiu Branden Wang, Jillian K. Riveros, Güneş Parlakgül, Karen E. Inouye, Grace Yankun Lee, Xiaorong Fu, Jani Saksi, Clement Rosique, Sheng Tony Hui, Mar Coll, Ana Paula Arruda, Shawn C. Burgess, Isabel Graupera and Gökhan S. Hotamışlıgil

Developmental trajectory and evolutionary origin of thymic mimetic cells pp. 1066-1075

Anja Nusser, Oliver S. Thomas, Gaoqun Zhang, Daisuke Nagakubo, Laura Arrigoni, Brigitte Krauth and Thomas Boehm

CREM is a regulatory checkpoint of CAR and IL-15 signalling in NK cells pp. 1076-1086

Hind Rafei, Rafet Basar, Sunil Acharya, Yu-Sung Hsu, Pinghua Liu, Deqiang Zhang, Toszka Bohn, Qingnan Liang, Vakul Mohanty, Ranjan Upadhyay, Ping Li, Pravin Phadatare, Merve Dede, Donghai Xiong, Huihui Fan, Corry Mathew Jones, Sebastian Kunz, May Daher, Ana Karen Nunez Cortes, Mayra Shanley, Bin Liu, Sadie Mae Moseley, Chenyu Zhang, Dexing Fang, Pinaki Banerjee, Nadima Uprety, Ye Li, Rejeena Shrestha, Xinhai Wan, Hong Shen, Vernikka Woods, April Lamour Gilbert, Seema Rawal, Jinzhuang Dou, Yukun Tan, Jeong-Min Park, Francia Reyes Silva, Alexander Biederstädt, Mecit Kaplan, Xin Ru Jiang, Inci Biederstädt, Bijender Kumar, Silvia Tiberti, Madison Moore, Jingling Jin, Ryan Z. Yang, Luis Muniz-Feliciano, Samuel Rosemore, Paul Lin, Gary M. Deyter, Natalie Wall Fowlkes, Abhinav K. Jain, David Marin, Anirban Maitra, Ken Chen, Tobias Bopp, Elizabeth J. Shpall and Katayoun Rezvani

Interferon-γ orchestrates leptomeningeal anti-tumour response pp. 1087-1096

Jan Remsik, Xinran Tong, Russell Z. Kunes, Min Jun Li, Rachel Estrera, Jenna Snyder, Clark Thomson, Ahmed M. Osman, Kiana Chabot, Ugur T. Sener, Jessica A. Wilcox, Danielle Isakov, Helen Wang, Tejus A. Bale, Ronan Chaligné, Joseph C. Sun, Chrysothemis Brown, Dana Pe’er and Adrienne Boire

In vivo haemopoietic stem cell gene therapy enabled by postnatal trafficking pp. 1097-1106

Michela Milani, Anna Fabiano, Marta Perez-Rodriguez, Raisa Jofra Hernandez, Alessandra Zecchillo, Erika Zonari, Sofia Ottonello, Luca Basso-Ricci, Cesare Canepari, Monica Volpin, Valeria Iannello, Valentina Capo, Pamela Quaranta, Luca Seffin, Fabio Russo, Mauro Biffi, Leonardo Ormoli, Chiara Brombin, Filippo Carlucci, Antonella Forlino, Marta Filibian, Eugenio Montini, Serena Scala, Anna Villa, Juan Antonio Bueren, Paula Rio, Alessandro Aiuti, Alessio Cantore and Luigi Naldini

Probing condensate microenvironments with a micropeptide killswitch pp. 1107-1116

Yaotian Zhang, Ida Stöppelkamp, Pablo Fernandez-Pernas, Melanie Allram, Matthew Charman, Alexandre P. Magalhaes, Melanie Piedavent-Salomon, Gregor Sommer, Yu-Chieh Sung, Katrina Meyer, Nicholas Grams, Edwin Halko, Shivali Dongre, David Meierhofer, Michal Malszycki, Ibrahim A. Ilik, Tugce Aktas, Matthew L. Kraushar, Nadine Vastenhouw, Matthew D. Weitzman, Florian Grebien, Henri Niskanen and Denes Hnisz

Molecular basis of SIFI activity in the integrated stress response pp. 1117-1126

Zhi Yang, Diane L. Haakonsen, Michael Heider, Samuel R. Witus, Alex Zelter, Tobias Beschauner, Michael J. MacCoss and Michael Rapé

Structural insights into human Pol III transcription initiation in action pp. 1127-1134

Qianmin Wang, Yulei Ren, Qianwei Jin, Xizi Chen and Yanhui Xu

Naturally ornate RNA-only complexes revealed by cryo-EM pp. 1135-1142

Rachael C. Kretsch, Yuan Wu, Svetlana A. Shabalina, Hyunbin Lee, Grace Nye, Eugene V. Koonin, Alex Gao, Wah Chiu and Rhiju Das

Meet the biotech-company founders driven by their child’s rare disease pp. 1143-1145

Rachel Brazil

Made-to-order DNA goes big: new tech doubles size of custom genetic sequences pp. 1146-1147

Caroline Seydel

‘We have less than ten minutes’: how I communicate with spacecraft from the ground pp. 1150-1150

Dave Tacon

2025, volume 643, articles 8072

Author Correction: Targeting the SHOC2–RAS interaction in RAS-mutant cancers pp. E14-E14

Zachary J. Hauseman, Frédéric Stauffer, Kim S. Beyer, Sandra Mollé, Elena Cavicchioli, Jean-Remy Marchand, Michelle Fodor, Jessica Viscomi, Anxhela Dhembi, Stéphanie Katz, Beatrice Faggion, Mylene Lanter, Grainne Kerr, Daniela Schildknecht, Cornelia Handl, Danilo Maddalo, Carole Pissot Soldermann, Jacob Brady, Om Shrestha, Zachary Nguyen, Lukas Leder, Gregor Cremosnik, Sandra Lopez Romero, Ulrich Hassiepen, Travis Stams, Markus Linder, Giorgio G. Galli, Daniel A. Guthy, Daniel A. King, Sauveur-Michel Maira, Claudio R. Thoma, Veronika Ehmke and Luca Tordella

Publisher Correction: Metabolic adaptations direct cell fate during tissue regeneration pp. E15-E15

Almudena Chaves-Perez, Scott E. Millman, Sudha Janaki-Raman, Yu-Jui Ho, Clemens Hinterleitner, Valentin J. A. Barthet, John P. Morris, Francisco M. Barriga, Jose Reyes, Aye Kyaw, H. Amalia Pasolli, Dana Pe’er, Craig B. Thompson, Lydia W. S. Finley, Justin R. Cross and Scott W. Lowe

Addendum: Unravelling cysteine-deficiency-associated rapid weight loss pp. E16-E16

Alan Varghese, Ivan Gusarov, Begoña Gamallo-Lana, Daria Dolgonos, Yatin Mankan, Ilya Shamovsky, Mydia Phan, Rebecca Jones, Maria Gomez-Jenkins, Eileen White, Rui Wang, Drew R. Jones, Thales Papagiannakopoulos, Michael E. Pacold, Adam C. Mar, Dan R. Littman and Evgeny Nudler

How to de-Americanize global science pp. 609-609

João Conde

Bring science into business schools to train the leaders of tomorrow pp. 610-610

Matthew Agarwala

China pours money into brain chips that give paralysed people more control pp. 613-614

Smriti Mallapaty

Symbolic ‘science fair’ showcases research cut by Trump team pp. 614-615

Jenna Ahart

Research-integrity sleuths say their work is being ‘twisted’ to undermine science pp. 615-616

Miryam Naddaf

Turbocharged ‘killer’ cells show promise for autoimmune disease pp. 616-617

Heidi Ledford

OpenAI’s o3 tops new AI league table for answering scientific questions pp. 617-618

Rachel Fieldhouse

Giant map details nerves across a mouse’s body: see stunning pics pp. 618-619

Mariana Lenharo

Rare find: interstellar visitor seen blazing through our Solar System pp. 620-620

Nicola Jones

The breakthrough proof bringing mathematics closer to a grand unified theory pp. 622-624

Ananyo Bhattacharya

Smart brain-zapping implants could revolutionize Parkinson’s treatment pp. 625-627

Sally Adee

AI hype, crackling northern lights and more: take it all in with these holiday reads pp. 628-630

Leor Zmigrod, Nyalleng Moorosi, Farhana Sultana, Anna Abalkina, Candice L. Odgers, Renata Libonati, Àlex Gómez-Marín, Monica McLemore, Genevieve L. Wojcik and Tae Jung Park

China’s shift towards ‘organized research’: how can coordination and innovation co-exist? pp. 631-634

Shuangmiao Han and Jing Xie

Why the global economy is more uncertain than ever, and what to do about it pp. 634-637

Brian M. Lucey, Andrew Urquhart and Samuel A. Vigne

Invest in data resources to make FAIR a reality pp. 638-638

Christophe Dessimoz, Frances H. Arnold, Richard J. Roberts and Tim Hubbard

Critical commentaries such as ‘Matters arising’ have flawed formats pp. 638-638

Veli-Matti Karhulahti

Map endemic species before they vanish unrecorded pp. 638-638

Daniel B. Montesinos-Tubée

China’s journal ranking system stands up to scrutiny pp. 638-638

Liying Yang

Investigating the molecular ‘scars’ of PTSD in the human brain pp. 639-640

Arturo Marroquin Rivera and Benoit Labonté

Super-resolution spectroscopy with ‘spiky’ X-ray lasers pp. 640-642

Mizuho Fushitani

The origin of the oldest solid objects in the Solar System pp. 642-643

Fred Ciesla

Sex differences in skin-cancer risk are linked to oestrogen levels pp. 643-644

Svenja Meierjohann

Close-in planet induces flares on its host star pp. 645-648

Ekaterina Ilin, Harish K. Vedantham, Katja Poppenhäger, Sanne Bloot, Joseph R. Callingham, Alexis Brandeker and Hritam Chakraborty

Refractory solid condensation detected in an embedded protoplanetary disk pp. 649-653

M. K. McClure, Merel van’t Hoff, Logan Francis, Edwin Bergin, Will R. M. Rocha, J. A. Sturm, Daniel Harsono, Ewine F. van Dishoeck, John H. Black, J. A. Noble, D. Qasim and E. Dartois

Signatures of chiral superconductivity in rhombohedral graphene pp. 654-661

Tonghang Han, Zhengguang Lu, Zach Hadjri, Lihan Shi, Zhenghan Wu, Wei Xu, Yuxuan Yao, Armel A. Cotten, Omid Sharifi Sedeh, Henok Weldeyesus, Jixiang Yang, Junseok Seo, Shenyong Ye, Muyang Zhou, Haoyang Liu, Gang Shi, Zhenqi Hua, Kenji Watanabe, Takashi Taniguchi, Peng Xiong, Dominik M. Zumbühl, Liang Fu and Long Ju

Super-resolution stimulated X-ray Raman spectroscopy pp. 662-668

Kai Li, Christian Ott, Marcus Agåker, Phay J. Ho, Gilles Doumy, Alexander Magunia, Marc Rebholz, Marc Simon, Tommaso Mazza, Alberto Fanis, Thomas M. Baumann, Jacobo Montano, Nils Rennhack, Sergey Usenko, Yevheniy Ovcharenko, Kalyani Chordiya, Lan Cheng, Jan-Erik Rubensson, Michael Meyer, Thomas Pfeifer, Mette B. Gaarde and Linda Young

Optical nonlinearities in excess of 500 through sublattice reconstruction pp. 669-674

Jiaye Chen, Chang Liu, Shibo Xi, Shengdong Tan, Qian He, Liangliang Liang and Xiaogang Liu

Broadband transient full-Stokes luminescence spectroscopy pp. 675-682

Antti-Pekka M. Reponen, Marcel Mattes, Zachary A. VanOrman, Lilian Estaque, Grégory Pieters and Sascha Feldmann

A cation-exchange approach to tunable magnetic intercalation superlattices pp. 683-690

Jingxuan Zhou, Jingyuan Zhou, Zhong Wan, Qi Qian, Huaying Ren, Xingxu Yan, Boxuan Zhou, Ao Zhang, Xiaoqing Pan, Wuzhang Fang, Yuan Ping, Zdenek Sofer, Yu Huang and Xiangfeng Duan

Pt migration–lockup in zeolite for stable propane dehydrogenation catalyst pp. 691-698

Zhikang Xu, Mingbin Gao, Yao Wei, Yuanyuan Yue, Zhengshuai Bai, Pei Yuan, Paolo Fornasiero, Jean-Marie Basset, Bingbao Mei, Zhongmin Liu, Haibo Zhu, Mao Ye and Xiaojun Bao

Electricity-driven enzymatic dynamic kinetic oxidation pp. 699-704

Beibei Zhao, Yuanyuan Xu, Qin Zhu, Aokun Liu, Xichao Peng, Tianying Zhang, Lu Yu, Yan Zhang and Xiaoqiang Huang

Global terrestrial nitrogen fixation and its modification by agriculture pp. 705-711

Carla R. Reis Ely, Steven S. Perakis, Cory C. Cleveland, Duncan N. L. Menge, Sasha C. Reed, Benton N. Taylor, Sarah A. Batterman, Christopher M. Clark, Timothy E. Crews, Katherine A. Dynarski, Maga Gei, Michael J. Gundale, David F. Herridge, Sarah E. Jovan, Sian Kou-Giesbrecht, Mark B. Peoples, Johannes Piipponen, Emilio Rodríguez-Caballero, Verity G. Salmon, Fiona M. Soper, Anika P. Staccone, Bettina Weber, Christopher A. Williams and Nina Wurzburger

Eighteen million years of diverse enamel proteomes from the East African Rift pp. 712-718

Daniel R. Green, Kevin T. Uno, Ellen R. Miller, Craig S. Feibel, Eipa Emmanuel Aoron, Catherine C. Beck, Aryeh Grossman, Francis M. Kirera, Martin M. Kirinya, Louise N. Leakey, Cynthia Liutkus-Pierce, Fredrick K. Manthi, Emmanuel K. Ndiema, Isaiah O. Nengo, Cyprian Nyete, John Rowan, Gabrielle A. Russo, William J. Sanders, Tara M. Smiley, Patricia Princehouse, Natasha S. Vitek and Timothy P. Cleland

Phylogenetically informative proteins from an Early Miocene rhinocerotid pp. 719-724

Ryan S. Paterson, Meaghan Mackie, Alessio Capobianco, Nicola S. Heckeberg, Danielle Fraser, Beatrice Demarchi, Fazeelah Munir, Ioannis Patramanis, Jazmín Ramos-Madrigal, Shanlin Liu, Abigail D. Ramsøe, Marc R. Dickinson, Chloë Baldreki, Marisa Gilbert, Raffaele Sardella, Luca Bellucci, Gabriele Scorrano, Michela Leonardi, Andrea Manica, Fernando Racimo, Eske Willerslev, Kirsty E. H. Penkman, Jesper V. Olsen, Ross D. E. MacPhee, Natalia Rybczynski, Sebastian Höhna and Enrico Cappellini

Motor learning refines thalamic influence on motor cortex pp. 725-734

Assaf Ramot, Felix H. Taschbach, Yun C. Yang, Yuxin Hu, Qiyu Chen, Bobbie C. Morales, Xinyi C. Wang, An Wu, Kay M. Tye, Marcus K. Benna and Takaki Komiyama

Systems consolidation reorganizes hippocampal engram circuitry pp. 735-743

Sangyoon Y. Ko, Yiming Rong, Adam I. Ramsaran, Xiaoyu Chen, Asim J. Rashid, Andrew J. Mocle, Jagroop Dhaliwal, Ankit Awasthi, Axel Guskjolen, Sheena A. Josselyn and Paul W. Frankland

Single-cell transcriptomic and chromatin dynamics of the human brain in PTSD pp. 744-754

Ahyeon Hwang, Mario Skarica, Siwei Xu, Jensine Coudriet, Che Yu Lee, Lin Lin, Rosemarie Terwilliger, Alexa-Nicole Sliby, Jiawei Wang, Tuan Nguyen, Hongyu Li, Min Wu, Yi Dai, Ziheng Duan, Shushrruth Sai Srinivasan, Xiangyu Zhang, Yingxin Lin, Dianne Cruz, P. J. Michael Deans, Bertrand R. Huber, Daniel Levey, Jill R. Glausier, David A. Lewis, Joel Gelernter, Paul E. Holtzheimer, Matthew J. Friedman, Mark Gerstein, Nenad Sestan, Kristen J. Brennand, Ke Xu, Hongyu Zhao, John H. Krystal, Keith A. Young, Douglas E. Williamson, Alicia Che, Jing Zhang and Matthew J. Girgenti

Increased CSF drainage by non-invasive manipulation of cervical lymphatics pp. 755-767

Hokyung Jin, Jin-Hui Yoon, Seon Pyo Hong, Yu Seok Hwang, Myung Jin Yang, Jieun Choi, Hae Jin Kang, Seung Eun Baek, Cheolhwa Jin, Junho Jung, Hae Jin Kim, Jincheol Seo, Jinyoung Won, Kyung Seob Lim, Chang-Yeop Jeon, Youngjeon Lee, Michael J. Davis, Hyung-Soon Park, Donald M. McDonald and Gou Young Koh

A kinase mediator of rhizobial symbiosis and immunity in Medicago pp. 768-775

Dapeng Wang, Rui Jin, Xiaobao Shi, Haoran Guo, Xinhang Tan, Achen Zhao, Xinghua Lian, Huiling Dai, Shaozhuang Li, Kexu Xin, Changfu Tian, Jun Yang, Wansheng Chen, Alberto P. Macho and Ertao Wang

Unravelling cysteine-deficiency-associated rapid weight loss pp. 776-784

Alan Varghese, Ivan Gusarov, Begoña Gamallo-Lana, Daria Dolgonos, Yatin Mankan, Ilya Shamovsky, Mydia Phan, Rebecca Jones, Maria Gomez-Jenkins, Eileen White, Rui Wang, Drew R. Jones, Thales Papagiannakopoulos, Michael E. Pacold, Adam C. Mar, Dan R. Littman and Evgeny Nudler

In vivo screen of Plasmodium targets for mosquito-based malaria control pp. 785-793

Alexandra S. Probst, Douglas G. Paton, Federico Appetecchia, Selina Bopp, Kelsey L. Adams, Tasneem A. Rinvee, Sovitj Pou, Rolf Winter, Esrah W. Du, Sabrina Yahiya, Charles Vidoudez, Naresh Singh, Janneth Rodrigues, Pablo Castañeda-Casado, Chiara Tammaro, Daisy Chen, Karla P. Godinez-Macias, Jasmine L. Jaramillo, Giovanna Poce, Michael J. Rubal, Aaron Nilsen, Elizabeth A. Winzeler, Jake Baum, Jeremy N. Burrows, Michael K. Riscoe, Dyann F. Wirth and Flaminia Catteruccia

A DNA-gated molecular guard controls bacterial Hailong anti-phage defence pp. 794-800

Joel M. J. Tan, Sarah Melamed, Joshua C. Cofsky, Deepsing Syangtan, Samuel J. Hobbs, Josefina Mármol, Marco Jost, Andrew C. Kruse, Rotem Sorek and Philip J. Kranzusch

Targeting GRPR for sex hormone-dependent cancer after loss of E-cadherin pp. 801-809

Jérémy H. Raymond, Zackie Aktary, Marie Pouteaux, Valérie Petit, Flavie Luciani, Maria Wehbe, Patrick Gizzi, Claire Bourban, Didier Decaudin, Fariba Nemati, Igor Martianov, Irwin Davidson, Catherine-Laure Tomasetto, Richard M. White, Florence Mahuteau-Betzer, Béatrice Vergier, Lionel Larue and Véronique Delmas

Radiation-induced amphiregulin drives tumour metastasis pp. 810-819

András Piffkó, Kaiting Yang, Arpit Panda, Janna Heide, Krystyna Tesak, Chuangyu Wen, Katarzyna Zawieracz, Liangliang Wang, Emile Z. Naccasha, Jason Bugno, Yanbin Fu, Dapeng Chen, Leonhard Donle, Ernst Lengyel, Douglas G. Tilley, Matthias Mack, Ronald S. Rock, Steven J. Chmura, Everett E. Vokes, Chuan He, Sean P. Pitroda, Hua Laura Liang and Ralph R. Weichselbaum

Solid phase transitions as a solution to the genome folding paradox pp. 820-829

Joan Pulupa, Natalie G. McArthur, Olga Stathi, Miao Wang, Marianna Zazhytska, Isabella D. Pirozzolo, Ahana Nayar, Lawrence Shapiro and Stavros Lomvardas

Range extender mediates long-distance enhancer activity pp. 830-838

Grace Bower, Ethan W. Hollingsworth, Sandra H. Jacinto, Joshua A. Alcantara, Benjamin Clock, Kaitlyn Cao, Mandy Liu, Adam Dziulko, Ana Alcaina-Caro, Qianlan Xu, Dorota Skowronska-Krawczyk, Javier Lopez-Rios, Diane E. Dickel, Anaïs F. Bardet, Len A. Pennacchio, Axel Visel and Evgeny Z. Kvon

In vivo mapping of mutagenesis sensitivity of human enhancers pp. 839-846

Michael Kosicki, Boyang Zhang, Vivian Hecht, Anusri Pampari, Laura E. Cook, Neil Slaven, Jennifer A. Akiyama, Ingrid Plajzer-Frick, Catherine S. Novak, Momoe Kato, Stella Tran, Riana D. Hunter, Kianna Maydell, Sarah Barton, Erik Beckman, Yiwen Zhu, Diane E. Dickel, Anshul Kundaje, Axel Visel and Len A. Pennacchio

Dynamic assemblies and coordinated reactions of non-homologous end joining pp. 847-854

Lan Liu, Jun Li, Metztli Cisneros-Aguirre, Arianna Merkell, Jeremy M. Stark, Martin Gellert and Wei Yang

Stepwise ATP translocation into the endoplasmic reticulum by human SLC35B1 pp. 855-864

Ashutosh Gulati, Do-Hwan Ahn, Albert Suades, Yurie Hult, Gernot Wolf, So Iwata, Giulio Superti-Furga, Norimichi Nomura and David Drew

Africa’s chief diplomat for vaccine manufacturing pp. 865-867

Abdullahi Tsanni

Need to update your data? Follow these five tips pp. 868-869

Sarah Wild

A motorcycle ride through the forest: how I protect Nigeria’s wildlife pp. 872-872

Linda Nordling

2025, volume 643, articles 8071

Lack of evidence for the transitional cerebellar progenitor pp. E1-E8

Kyle S. Smith, Yiran Li, Parthiv Haldipur, Brian L. Gudenas, Kathleen J. Millen, Volker Hovestadt and Paul A. Northcott

Author Correction: RUNX2 promotes fibrosis via an alveolar-to-pathological fibroblast transition pp. E9-E9

Yinshan Fang, Sanny S. W. Chung, Le Xu, Chenyi Xue, Xue Liu, Dianhua Jiang, Rongbo Li, Yohei Korogi, Ke Yuan, Anjali Saqi, Hanina Hibshoosh, Yuefeng Huang, Chyuan-Sheng Lin, Takeshi Takarada, Tatsuya Tsukui, Dean Sheppard, Xin Sun and Jianwen Que

Author Correction: Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome pp. E10-E10

Hua Su, Fei Yang, Rao Fu, Brittney Trinh, Nina Sun, Junlai Liu, Avi Kumar, Jacopo Baglieri, Jeremy Siruno, Michelle Le, Yuhan Li, Stephen Dozier, Ajay Nair, Aveline Filliol, Nachanok Sinchai, Sara Brin Rosenthal, Jennifer Santini, Christian M. Metallo, Anthony Molina, Robert F. Schwabe, Andrew M. Lowy, David A. Brenner, Beicheng Sun and Michael Karin

Author Correction: Regulatory genomic circuitry of human disease loci by integrative epigenomics pp. E11-E11

Carles A. Boix, Benjamin T. James, Yongjin P. Park, Wouter Meuleman and Manolis Kellis

Publisher Correction: The P-loop NTPase RUVBL2 is a conserved clock component across eukaryotes pp. E12-E12

Meimei Liao, Yanqin Liu, Zhancong Xu, Mingxu Fang, Ziqing Yu, Yufan Cui, Zhengda Sun, Ran Huo, Jieyu Yang, Fusheng Huang, Mingming Liu, Qin Zhou, Xiaocui Song, Hui Han, She Chen, Xiaodong Xu, Ximing Qin, Qun He, Dapeng Ju, Tao Wang, Nirav Thakkar, Paul E. Hardin, Susan S. Golden and Eric Erquan Zhang

Editorial Expression of Concern: Transformation of primary human endothelial cells by Kaposi’s sarcoma-associated herpesvirus pp. E13-E13

Ornella Flore, Shahin Rafii, Scott Ely, John J. O’Leary, Elizabeth M. Hyjek and Ethel Cesarman

Deaf scientists hit by drastic NIH cuts — the research community must support them pp. 305-305

Wyatte C. Hall

How we’re rebuilding the Weizmann Institute — and our hopes for a better future pp. 306-306

Alon Chen

Turmoil at US science academy as Trump cuts force layoffs pp. 309-310

Jeff Tollefson and Dan Garisto

First independent survey of deaths in Gaza reports more than 80,000 fatalities pp. 311-312

Rachel Fieldhouse

Arrests of scientists over smuggled samples add to US border anxiety pp. 312-313

Humberto Basilio

How to speed up peer review: make applicants mark one another pp. 313-314

Helen Pearson

How fast are you ageing? Ordinary brain scans reveal the pace pp. 314-315

Heidi Ledford

Obesity drugs made in China could power next wave of treatments pp. 315-316

Rachel Fieldhouse

Stare into a whale’s colossal eye — June’s best science images pp. 316-316

Katie Kavanagh

Stress is wrecking your health: how can science help? pp. 318-320

Lynne Peeples

World’s most porous sponges: intricate carbon-trapping powders hit the market pp. 322-324

Katharine Sanderson

Science on the catwalk: Iris van Herpen gives gowns a glow up pp. 325-327

Laura Spinney

Will AI speed up literature reviews or derail them entirely? pp. 329-331

Sam A. Reynolds, Alec P. Christie, Lynn V. Dicks, Sadiq Jaffer, Anil Madhavapeddy, Rebecca K. Smith and William J. Sutherland

How to chart a moral future for space exploration pp. 332-335

Chelsea Haramia, Émilie A. Laflèche, Julia De Marines and Michael L. Wong

Support Sudan’s displaced young scientists pp. 336-336

Hisham Y. Hassan

Old CO₂ released from rivers complicates evaluations of fossil-fuel emissions pp. 336-336

Xiongwei Liang and Yingning Wang

Expand biobank sampling to three or more generations pp. 336-336

Shinichi Kuriyama, Taku Obara, Jochen Mierau and Harold Snieder

Address Colombia’s brain-health crisis pp. 336-336

Juan F. Cardona, Catalina Trujillo-Llano, Johnny Miller and Agustín Ibañez

First returned rock samples shine a light on the Moon’s ‘dark side’ pp. 337-338

Stephen M. Elardo

Biochemical breakthrough paves way to reliable supply of anticancer drug pp. 339-340

Jakob Franke

An open AI model could help medical experts to interpret chest X-rays pp. 340-341

Namkug Kim

Nanoplastics make up most of the plastic pollutants in the North Atlantic Ocean pp. 341-343

Katsiaryna Pabortsava

Mitochondrial molecule has unexpected role in tissue healing pp. 343-344

Ram P. Chakrabarty and Navdeep S. Chandel

Various cell types in tissues cooperate in networks that are disrupted in disease pp. 344-346

Mirjana Efremova

Mixed plastics turned into valuable chemicals pp. 346-347

Matthew Jones

Mapping the chemical complexity of plastics pp. 349-355

L. Monclús, H. P. H. Arp, K. J. Groh, A. Faltynkova, M. E. Løseth, J. Muncke, Z. Wang, R. Wolf, L. Zimmermann and M. Wagner

Lunar farside volcanism 2.8 billion years ago from Chang’e-6 basalts pp. 356-360

Qian W. L. Zhang, Mu-Han Yang, Qiu-Li Li, Yu Liu, Zong-Yu Yue, Qin Zhou, Liu-Yang Chen, Hong-Xia Ma, Sai-Hong Yang, Xu Tang, Guang-Liang Zhang, Xin Ren and Xian-Hua Li

A reinforced lunar dynamo recorded by Chang’e-6 farside basalt pp. 361-365

Shuhui Cai, Kaixian Qi, Saihong Yang, Jie Fang, Pingyuan Shi, Zhongshan Shen, Min Zhang, Huafeng Qin, Chi Zhang, Xiaoguang Li, Fangfang Chen, Yi Chen, Jinhua Li, Huaiyu He, Chenglong Deng, Chunlai Li, Yongxin Pan and Rixiang Zhu

Water abundance in the lunar farside mantle pp. 366-370

Huicun He, Linxi Li, Sen Hu, Yubing Gao, Liang Gao, Zhan Zhou, Mengfan Qiu, Disheng Zhou, Huanxin Liu, Ruiying Li, Jialong Hao, Hejiu Hui and Yangting Lin

Ultra-depleted mantle source of basalts from the South Pole–Aitken basin pp. 371-375

Qin Zhou, Wei Yang, Zhuyin Chu, Honggang Zhu, Saihong Yang, Xingguo Zeng, Ding-Shuai Xue, Li-Hui Jia, Guangliang Zhang, Hongbo Zhang, Yanhao Lin, Huijuan Zhang, Heng-Ci Tian, Peng Peng, Dan-Ping Zhang, Lixin Gu, Chunlai Li and Fu-Yuan Wu

Moiré materials based on M-point twisting pp. 376-381

Dumitru Călugăru, Yi Jiang, Haoyu Hu, Hanqi Pi, Jiabin Yu, Maia G. Vergniory, Jie Shan, Claudia Felser, Leslie M. Schoop, Dmitri K. Efetov, Kin Fai Mak and B. Andrei Bernevig

Spin-qubit control with a milli-kelvin CMOS chip pp. 382-387

Samuel K. Bartee, Will Gilbert, Kun Zuo, Kushal Das, Tuomo Tanttu, Chih Hwan Yang, Nard Dumoulin Stuyck, Sebastian J. Pauka, Rocky Y. Su, Wee Han Lim, Santiago Serrano, Christopher C. Escott, Fay E. Hudson, Kohei M. Itoh, Arne Laucht, Andrew S. Dzurak and David J. Reilly

Bioinspired capillary force-driven super-adhesive filter pp. 388-394

Junyong Park, Chan Sik Moon, Ji Min Lee, Sazzadul A. Rahat, Sang Moon Kim, Jonathan T. Pham, Michael Kappl, Hans-Jürgen Butt and Sanghyuk Wooh

In-line NMR guided orthogonal transformation of real-life plastics pp. 395-403

Mei-Qi Zhang, Yida Zhou, Ruochen Cao, Shuheng Tian, Yuchen Jiao, Zhenbo Guo, Maolin Wang, Hongpeng Peng, Bo Sun, Bingjun Xu, Meng Wang, Shutao Xu and Ding Ma

Control of toxicity of fine particulate matter emissions in China pp. 404-411

Haotian Zheng, Di Wu, Shuxiao Wang, Xiangdong Li, Ling N. Jin, Bin Zhao, Shengyue Li, Yisheng Sun, Zhaoxin Dong, Qingru Wu, Xiu Chen, Yuzhe Liu, Jianmin Chen, Hezhong Tian, Qian Liu, Jingkun Jiang, Haidong Kan, Kebin He, Hong He, Chuncheng Chen, Jincai Zhao, Scott Weichenthal, John S. Ji, Aaron J. Cohen, Jiming Hao and Qing Li

Nanoplastic concentrations across the North Atlantic pp. 412-416

Sophie Hietbrink, Dušan Materić, Rupert Holzinger, Sjoerd Groeskamp and Helge Niemann

Genome diversity and signatures of natural selection in mainland Southeast Asia pp. 417-426

Yaoxi He, Xiaoming Zhang, Min-Sheng Peng, Yu-Chun Li, Kai Liu, Yu Zhang, Leyan Mao, Yongbo Guo, Yujie Ma, Bin Zhou, Wangshan Zheng, Tian Yue, Yuwen Liao, Shen-Ao Liang, Lu Chen, Weijie Zhang, Xiaoning Chen, Bixia Tang, Xiaofei Yang, Kai Ye, Shenghan Gao, Yurun Lu, Yong Wang, Shijie Wan, Rushan Hao, Xuankai Wang, Yafei Mao, Shanshan Dai, Zongliang Gao, Li-Qin Yang, Jianxin Guo, Jiangguo Li, Chao Liu, Jianhua Wang, Tuot Sovannary, Long Bunnath, Jatupol Kampuansai, Angkhana Inta, Metawee Srikummool, Wibhu Kutanan, Huy Quang Ho, Khoa Dang Pham, Sommay Singthong, Somphad Sochampa, U. Win Kyaing, Wittaya Pongamornkul, Chutima Morlaeku, Kittisak Rattanakrajangsri, Qing-Peng Kong, Ya-Ping Zhang and Bing Su

Human de novo mutation rates from a four-generation pedigree reference pp. 427-436

David Porubsky, Harriet Dashnow, Thomas A. Sasani, Glennis A. Logsdon, Pille Hallast, Michelle D. Noyes, Zev N. Kronenberg, Tom Mokveld, Nidhi Koundinya, Cillian Nolan, Cody J. Steely, Andrea Guarracino, Egor Dolzhenko, William T. Harvey, William J. Rowell, Kirill Grigorev, Thomas J. Nicholas, Michael E. Goldberg, Keisuke K. Oshima, Jiadong Lin, Peter Ebert, W. Scott Watkins, Tiffany Y. Leung, Vincent C. T. Hanlon, Sean McGee, Brent S. Pedersen, Hannah C. Happ, Hyeonsoo Jeong, Katherine M. Munson, Kendra Hoekzema, Daniel D. Chan, Yanni Wang, Jordan Knuth, Gage H. Garcia, Cairbre Fanslow, Christine Lambert, Charles Lee, Joshua D. Smith, Shawn Levy, Christopher E. Mason, Erik Garrison, Peter M. Lansdorp, Deborah W. Neklason, Lynn B. Jorde, Aaron R. Quinlan, Michael A. Eberle and Evan E. Eichler

Heterogeneous pericoerulear neurons tune arousal and exploratory behaviours pp. 437-447

Andrew T. Luskin, Li Li, Xiaonan Fu, Madison M. Martin, Kelsey Barcomb, Kasey S. Girven, Taylor Blackburn, Bailey A. Wells, Sarah T. Thai, Esther M. Li, Akshay N. Rana, Rhiana C. Simon, Li Sun, Lei Gao, Alexandria D. Murry, Sam A. Golden, Garret D. Stuber, Christopher P. Ford, Liangcai Gu and Michael R. Bruchas

Dopamine D1–D2 signalling in hippocampus arbitrates approach and avoidance pp. 448-457

Arthur Godino, Marine Salery, Angelica M. Minier-Toribio, Vishwendra Patel, John F. Fullard, Veronika Kondev, Eric M. Parise, Freddyson J. Martinez-Rivera, Carole Morel, Panos Roussos, Robert D. Blitzer and Eric J. Nestler

Striatum supports fast learning but not memory recall pp. 458-467

Kimberly Reinhold, Marci Iadarola, Shi Tang, Annabel Chang, Whitney Kuwamoto, Madeline A. Albanese, Senmiao Sun, Richard Hakim, Joshua Zimmer, Wengang Wang and Bernardo L. Sabatini

Metabolic adaptations direct cell fate during tissue regeneration pp. 468-477

Almudena Chaves-Perez, Scott E. Millman, Sudha Janaki-Raman, Yu-Jui Ho, Clemens Hinterleitner, Valentin J. A. Barthet, John P. Morris, Francisco M. Barriga, Jose Reyes, Aye Kyaw, H. Amalia Pasolli, Dana Pe’er, Craig B. Thompson, Lydia W. S. Finley, Justin R. Cross and Scott W. Lowe

Clonal tracing with somatic epimutations reveals dynamics of blood ageing pp. 478-487

Michael Scherer, Indranil Singh, Martina Maria Braun, Chelsea Szu-Tu, Pedro Sanchez Sanchez, Dominik Lindenhofer, Niels Asger Jakobsen, Verena Körber, Michael Kardorff, Lena Nitsch, Pauline Kautz, Julia Rühle, Agostina Bianchi, Luca Cozzuto, Robert Frömel, Sergi Beneyto-Calabuig, Caleb Lareau, Ansuman T. Satpathy, Renée Beekman, Lars M. Steinmetz, Simon Raffel, Leif S. Ludwig, Paresh Vyas, Alejo Rodriguez-Fraticelli and Lars Velten

A fully open AI foundation model applied to chest radiography pp. 488-498

DongAo Ma, Jiaxuan Pang, Michael B. Gotway and Jianming Liang

The subfornical organ is a nucleus for gut-derived T cells that regulate behaviour pp. 499-508

Tomomi M. Yoshida, Mytien Nguyen, Le Zhang, Benjamin Y. Lu, Biqing Zhu, Katie N. Murray, Yann S. Mineur, Cuiling Zhang, Di Xu, Elizabeth Lin, Joseph Luchsinger, Sagar Bhatta, Daniel A. Waizman, Mackenzie E. Coden, Yifan Ma, Kavita Israni-Winger, Anthony Russo, Haowei Wang, Wenzhi Song, Jafar Al Souz, Hongyu Zhao, Joseph E. Craft, Marina R. Picciotto, Jaime Grutzendler, Marcello Distasio, Noah W. Palm, David A. Hafler and Andrew Wang

Gut inflammation promotes microbiota-specific CD4 T cell-mediated neuroinflammation pp. 509-518

Zachary White, Ivan Cabrera, Linghan Mei, Margarette Clevenger, Andrea Ochoa-Raya, Isabel Kapustka, Joseph R. Dominguez, Jinyan Zhou, Kevin P. Koster, Shehata Anwar, Qianxun Wang, Charles Ng, Shoko Sagoshi, Takashi Matsuo, Dulari Jayawardena, Seung Hyeon Kim, Takahiro Kageyama, Benjamin J. Mitchell, Dante Rivera, Pradeep K. Dudeja, Sarah E. Lutz, Ki-Wook Kim, Akira Yoshii, Nicolas Chevrier, Makoto Inoue and Teruyuki Sano

STAT5 and STAT3 balance shapes dendritic cell function and tumour immunity pp. 519-528

Jiajia Zhou, Kole Tison, Haibin Zhou, Longchuan Bai, Ranjan Kumar Acharyya, Donna McEachern, Hoda Metwally, Yu Wang, Michael Pitter, Jae Eun Choi, Linda Vatan, Peng Liao, Jiali Yu, Heng Lin, Long Jiang, Shuang Wei, Xue Gao, Sara Grove, Abhijit Parolia, Marcin Cieslik, Ilona Kryczek, Michael D. Green, Jian-Xin Lin, Arul M. Chinnaiyan, Warren J. Leonard, Shaomeng Wang and Weiping Zou

Cross-tissue multicellular coordination and its rewiring in cancer pp. 529-538

Qiang Shi, Yihan Chen, Yang Li, Shishang Qin, Yu Yang, Yang Gao, Linnan Zhu, Dongfang Wang and Zemin Zhang

Custom CRISPR–Cas9 PAM variants via scalable engineering and machine learning pp. 539-550

Rachel A. Silverstein, Nahye Kim, Ann-Sophie Kroell, Russell T. Walton, Justin Delano, Rossano M. Butcher, Martin Pacesa, Blaire K. Smith, Kathleen A. Christie, Leillani L. Ha, Ronald J. Meis, Aaron B. Clark, Aviv D. Spinner, Cicera R. Lazzarotto, Yichao Li, Azusa Matsubara, Elizabeth O. Urbina, Gary A. Dahl, Bruno E. Correia, Debora S. Marks, Shengdar Q. Tsai, Luca Pinello, Suk See Ravin, Qin Liu and Benjamin P. Kleinstiver

Oncogenic fusions converge on shared mechanisms in initiating astroblastoma pp. 551-561

Yixing Shi, Qianqian Sun, Fuchuan Jia, Xiangyu Xie, Xiangyu Zhou, Rong Guo, Yangfan Zeng, Shanshan Chen, Zhenzhen Guo, Wenli Sun, Tong Guo, Yu Xia, Wenlong Li, Li Zhang, Wei Shi and Yang Yu

Ku limits RNA-induced innate immunity to allow Alu expansion in primates pp. 562-571

Yimeng Zhu, Angelina Li, Suvrajit Maji, Brian J. Lee, Sophie M. Korn, Jake A. Gertie, Tyler J. Dorrity, Jianhua Wang, Kyle J. Wang, Amandine Pelletier, Daniel F. Moakley, Rachel D. Kelly, Antony B. Holmes, Raul Rabadan, David R. Edgell, Caroline Schild-Poulter, Mauro Modesti, Anna-Lena Steckelberg, Eric A. Hendrickson, Hachung Chung, Chaolin Zhang and Shan Zha

Native nucleosomes intrinsically encode genome organization principles pp. 572-581

Sangwoo Park, Raquel Merino-Urteaga, Violetta Karwacki-Neisius, Gustavo Ezequiel Carrizo, Advait Athreya, Alberto Marin-Gonzalez, Nils A. Benning, Jonghan Park, Michelle M. Mitchener, Natarajan V. Bhanu, Benjamin A. Garcia, Bin Zhang, Tom W. Muir, Erika L. Pearce and Taekjip Ha

Discovery of FoTO1 and Taxol genes enables biosynthesis of baccatin III pp. 582-592

Conor James McClune, Jack Chun-Ting Liu, Chloe Wick, Ricardo De La Peña, Bernd Markus Lange, Polly M. Fordyce and Elizabeth S. Sattely

Rubbish years: how to boost lab group morale when world events crash in pp. 593-595

N. G. Boeck

Will algorithms choose your next lab colleague? pp. 596-598

Linda Nordling

How monitoring a remote Finnish peatland helps climate science pp. 600-600

Francesco Martinelli

2025, volume 643, articles 8070

Why we need mandatory safeguards for emotionally responsive AI pp. 9-9

Ziv Ben-Zion

What we stand to lose when foreign students are seen as a threat pp. 10-10

Maia Chankseliani

Can AI build a virtual cell? Scientists race to model life’s smallest unit pp. 13-14

Ewen Callaway

These scientists re-enacted Stone Age voyage to Japan’s remote islands pp. 14-15

Katie Kavanagh

Does using ChatGPT change your brain activity? Study sparks debate pp. 15-16

Nicola Jones

How many PhDs does the world need? Doctoral graduates vastly outnumber jobs in academia pp. 16-17

Diana Kwon

DeepMind’s new AlphaGenome AI tackles the ‘dark matter’ in our DNA pp. 17-18

Ewen Callaway

First images from world’s largest digital camera leave astronomers in awe pp. 18-19

Davide Castelvecchi

Everyday painkiller made from plastic — by E. coli pp. 19-19

Rita Aksenfeld

Happy birthday Jaws! How the movie changed shark science pp. 20-20

Katie Kavanagh

AI ‘scientists’ joined these research teams: here’s what happened pp. 22-25

Nicola Jones

Harvard vs Trump: what this epic battle means for science pp. 26-27

Jeff Tollefson

What do dolphins talk about? One biologist is trying to listen in pp. 28-29

Laela Sayigh

Niède Guidon obituary: Brazilian archaeologist who upended ideas on early human migration pp. 30-30

Meghie Rodrigues

Human embryo research: how to move towards a 28-day limit pp. 31-34

Alejandro De Los Angeles, Nissim Benvenisty, Hongkui Deng, Jacob H. Hanna, Julian Koplin, Tianqing Li, Pentao Liu, Yuin-Han Loh, Duanqing Pei, Ryohichi Sugimura, Timothy Theodore Ka Ki Tam, Tan Tao, Alan Trounson, Shao Xu, Leqian Yu, Elias Zambidis, Magdalena Zernicka-Goetz and Robin Lovell-Badge

Protect Iran’s scientists from attacks pp. 35-35

Navid Madani

Human space travel risks contaminating Mars pp. 35-35

Alberto G. Fairén

Global pandemic agreement needs sustained pressure to succeed pp. 35-35

WooJung Jon

It should be free to apply to graduate school pp. 35-35

Benjamin Fernando, Michael Cassidy, Angela Russell and Aris Katzourakis

Tunnelling photons challenge interpretation of quantum mechanics pp. 37-38

Alessandro Fedrizzi and Fabio Biancalana

A bile acid could explain how calorie restriction slows ageing pp. 38-40

David A. Sinclair

Natural nappers: monitoring the sleeping patterns of wild orangutans pp. 39-39

Mary Abraham

Computer-vision research is hiding its role in creating ‘Big Brother’ technologies pp. 41-42

Jathan Sadowski

Deciphering how dog roses with an odd chromosome copy number sexually reproduce pp. 42-43

Adrián Gonzalo and Joiselle B. Fernandes

Sticky membranes of dead red blood cells obstruct small vessels pp. 44-45

Elizabeth Iffrig and Wilbur A. Lam

Iron deficiency in pregnant mice causes XY embryos to develop with female characteristics pp. 45-46

Shannon Dupont and Blanche Capel

The Somatic Mosaicism across Human Tissues Network pp. 47-59

Tim H. H. Coorens, Ji Won Oh, Yujin Angelina Choi, Nam Seop Lim, Boxun Zhao, Adam Voshall, Alexej Abyzov, Lucinda Antonacci-Fulton, Samuel Aparicio, Kristin G. Ardlie, Thomas J. Bell, James T. Bennett, Bradley E. Bernstein, Thomas G. Blanchard, Alan P. Boyle, Jason D. Buenrostro, Kathleen H. Burns, Fei Chen, Rui Chen, Sangita Choudhury, Harsha V. Doddapaneni, Evan E. Eichler, Gilad D. Evrony, Melissa A. Faith, Thomas G. Fazzio, Robert S. Fulton, Manuel Garber, Nils Gehlenborg, Soren Germer, Gad Getz, Richard A. Gibbs, Raquel G. Hernandez, Fulai Jin, Jan O. Korbel, Dan A. Landau, Heather A. Lawson, Niall J. Lennon, Heng Li, Yan Li, Po-Ru Loh, Gabor Marth, Michael J. McConnell, Ryan E. Mills, Stephen B. Montgomery, Pradeep Natarajan, Peter J. Park, Rahul Satija, Fritz J. Sedlazeck, Diane D. Shao, Hui Shen, Andrew B. Stergachis, Hunter R. Underhill, Alexander E. Urban, Melissa W. VonDran, Christopher A. Walsh, Ting Wang, Tao P. Wu, Chenghang Zong, Eunjung Alice Lee and Flora M. Vaccarino

Carbonate formation and fluctuating habitability on Mars pp. 60-66

Edwin S. Kite, Benjamin M. Tutolo, Madison L. Turner, Heather B. Franz, David G. Burtt, Thomas F. Bristow, Woodward W. Fischer, Ralph E. Milliken, Abigail A. Fraeman and Daniel Y. Zhou

Energy–speed relationship of quantum particles challenges Bohmian mechanics pp. 67-72

Violetta Sharoglazova, Marius Puplauskis, Charlie Mattschas, Chris Toebes and Jan Klaers

Computer-vision research powers surveillance technology pp. 73-79

Pratyusha Ria Kalluri, William Agnew, Myra Cheng, Kentrell Owens, Luca Soldaini and Abeba Birhane

Ultrabroadband and band-selective thermal meta-emitters by machine learning pp. 80-88

Chengyu Xiao, Mengqi Liu, Kan Yao, Yifan Zhang, Mengqi Zhang, Max Yan, Ya Sun, Xianghui Liu, Xuanyu Cui, Tongxiang Fan, Changying Zhao, Wansu Hua, Yinqiao Ying, Yuebing Zheng, Di Zhang, Cheng-Wei Qiu and Han Zhou

Controlling diverse robots by inferring Jacobian fields with deep networks pp. 89-95

Sizhe Lester Li, Annan Zhang, Boyuan Chen, Hanna Matusik, Chao Liu, Daniela Rus and Vincent Sitzmann

Weakly space-confined all-inorganic perovskites for light-emitting diodes pp. 96-103

Chenchen Peng, Haitao Yao, Othman Ali, Wenjing Chen, Yingguo Yang, Zongming Huang, Hui Liu, Jianyu Li, Tao Chen, Zhijian Li, Mei Sun, Hongmin Zhou, Xiangru Tao, Nana Wang, Jianpu Wang and Zhengguo Xiao

Efficient near-infrared harvesting in perovskite–organic tandem solar cells pp. 104-110

Zhenrong Jia, Xiao Guo, Xinxing Yin, Ming Sun, Jiawei Qiao, Xinyu Jiang, Xi Wang, Yuduan Wang, Zijing Dong, Zhuojie Shi, Chun-Hsiao Kuan, Jingcong Hu, Qilin Zhou, Xiangkun Jia, Jinxi Chen, Zhouyin Wei, Shunchang Liu, Haoming Liang, Nengxu Li, Ling Kai Lee, Renjun Guo, Stephan V. Roth, Peter Müller-Buschbaum, Xiaotao Hao, Xiaoyan Du and Yi Hou

A cost-effective all-in-one halide material for all-solid-state batteries pp. 111-118

Jiamin Fu, Changhong Wang, Shuo Wang, Joel W. Reid, Jianwen Liang, Jing Luo, Jung Tae Kim, Yang Zhao, Xiaofei Yang, Feipeng Zhao, Weihan Li, Bolin Fu, Xiaoting Lin, Yang Hu, Han Su, Xiaoge Hao, Yingjie Gao, Shutao Zhang, Ziqing Wang, Jue Liu, Hamid Abdolvand, Tsun-Kong Sham, Yifei Mo and Xueliang Sun

Machine-learning design of ductile FeNiCoAlTa alloys with high strength pp. 119-124

Yasir Sohail, Chongle Zhang, Dezhen Xue, Jinyu Zhang, Dongdong Zhang, Shaohua Gao, Yang Yang, Xiaoxuan Fan, Hang Zhang, Gang Liu, Jun Sun and En Ma

Soft magnetic hysteresis in a dysprosium amide–alkene complex up to 100 kelvin pp. 125-129

Jack Emerson-King, Gemma K. Gransbury, Benjamin E. Atkinson, William J. A. Blackmore, George F. S. Whitehead, Nicholas F. Chilton and David P. Mills

One-carbon homologation of alkenes pp. 130-138

Marcus C. Grocott and Matthew J. Gaunt

Punic people were genetically diverse with almost no Levantine ancestors pp. 139-147

Harald Ringbauer, Ayelet Salman-Minkov, Dalit Regev, Iñigo Olalde, Tomer Peled, Luca Sineo, Gioacchino Falsone, Peter Dommelen, Alissa Mittnik, Iosif Lazaridis, Davide Pettener, Maria Bofill, Ana Mezquida, Benjamí Costa, Helena Jiménez, Patricia Smith, Stefania Vai, Alessandra Modi, Arie Shaus, Kim Callan, Elizabeth Curtis, Aisling Kearns, Ann Marie Lawson, Matthew Mah, Adam Micco, Jonas Oppenheimer, Lijun Qiu, Kristin Stewardson, J. Noah Workman, Nicholas Márquez-Grant, Antonio M. Sáez Romero, María Luisa Lavado Florido, Juan Manuel Jiménez-Arenas, Isidro Jorge Toro Moyano, Enrique Viguera, José Suárez Padilla, Sonia López Chamizo, Tomas Marques-Bonet, Esther Lizano, Alicia Rodero Riaza, Francesca Olivieri, Pamela Toti, Valentina Giuliana, Alon Barash, Liran Carmel, Elisabetta Boaretto, Marina Faerman, Michaela Lucci, Francesco Pastina, Alessia Nava, Francesco Genchi, Carla Vais, Gabriele Lauria, Francesca Meli, Paola Sconzo, Giulio Catalano, Elisabetta Cilli, Anna Chiara Fariselli, Francesco Fontani, Donata Luiselli, Brendan J. Culleton, Swapan Mallick, Nadin Rohland, Lorenzo Nigro, Alfredo Coppa, David Caramelli, Ron Pinhasi, Carles Lalueza-Fox, Ilan Gronau and David Reich

Bimodal centromeres in pentaploid dogroses shed light on their unique meiosis pp. 148-157

V. Herklotz, M. Zhang, T. Nascimento, R. Kalfusová, J. Lunerová, J. Fuchs, D. Harpke, B. Huettel, U. Pfordt, V. Wissemann, A. Kovařík, A. Marques and C. M. Ritz

Comparative connectomics of Drosophila descending and ascending neurons pp. 158-172

Tomke Stürner, Paul Brooks, Laia Serratosa Capdevila, Billy J. Morris, Alexandre Javier, Siqi Fang, Marina Gkantia, Sebastian Cachero, Isabella R. Beckett, Elizabeth C. Marin, Philipp Schlegel, Andrew S. Champion, Ilina Moitra, Alana Richards, Finja Klemm, Leonie Kugel, Shigehiro Namiki, Han S. J. Cheong, Julie Kovalyak, Emily Tenshaw, Ruchi Parekh, Jasper S. Phelps, Brandon Mark, Sven Dorkenwald, Alexander S. Bates, Arie Matsliah, Szi-chieh Yu, Claire E. McKellar, Amy Sterling, H. Sebastian Seung, Mala Murthy, John C. Tuthill, Wei-Chung Allen Lee, Gwyneth M. Card, Marta Costa, Gregory S. X. E. Jefferis and Katharina Eichler

Regulation of PV interneuron plasticity by neuropeptide-encoding genes pp. 173-181

Martijn Selten, Clémence Bernard, Diptendu Mukherjee, Fursham Hamid, Alicia Hanusz-Godoy, Fazal Oozeer, Christoph Zimmer and Oscar Marín

Ischaemic endothelial necroptosis induces haemolysis and COVID-19 angiopathy pp. 182-191

Mike C. L. Wu, Ethan Italiano, Rocko Jarvis-Child, Imala Alwis, Rhyll Smythe, Eduardo A. Albornoz, Jonathan Noonan, Marie Portelli, Marissa Baptista, Jessica Maclean, Pashtana Noori, Jinglu Yang, John D. Lee, James D. McFadyen, Alexandra F. Sharland, Trent M. Woodruff, Andre L. Samson, Amy Rapkiewicz, Tessa J. Barrett, Alan Pham, Simone M. Schoenwaelder, Yuping Yuan and Shaun P. Jackson

Lithocholic acid phenocopies anti-ageing effects of calorie restriction pp. 192-200

Qi Qu, Yan Chen, Yu Wang, Shating Long, Weiche Wang, Heng-Ye Yang, Mengqi Li, Xiao Tian, Xiaoyan Wei, Yan-Hui Liu, Shengrong Xu, Cixiong Zhang, Mingxia Zhu, Sin Man Lam, Jianfeng Wu, Chuyu Yun, Junjie Chen, Shengye Xue, Baoding Zhang, Zhong-Zheng Zheng, Hai-Long Piao, Changtao Jiang, Hao Guo, Guanghou Shui, Xianming Deng, Chen-Song Zhang and Sheng-Cai Lin

Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing pp. 201-209

Qi Qu, Yan Chen, Yu Wang, Weiche Wang, Shating Long, Heng-Ye Yang, Jianfeng Wu, Mengqi Li, Xiao Tian, Xiaoyan Wei, Yan-Hui Liu, Shengrong Xu, Jinye Xiong, Chunyan Yang, Zhenhua Wu, Xi Huang, Changchuan Xie, Yaying Wu, Zheni Xu, Cixiong Zhang, Baoding Zhang, Jin-Wei Feng, Junjie Chen, Yuanji Feng, Huapan Fang, Liyun Lin, Xie Zk, Beibei Sun, Huayu Tian, Yong Yu, Hai-Long Piao, Xiao-Song Xie, Xianming Deng, Chen-Song Zhang and Sheng-Cai Lin

Targeting symbionts by apolipoprotein L proteins modulates gut immunity pp. 210-218

Tao Yang, Xiaohu Hu, Fei Cao, Fenglin Yun, Kaiwen Jia, Mingxiang Zhang, Gaohui Kong, Biyu Nie, Yuexing Liu, Haohao Zhang, Xiaoyu Li, Hongyan Gao, Jiantao Shi, Guanxiang Liang, Guohong Hu, Dennis L. Kasper, Xinyang Song and Youcun Qian

Glioblastoma-instructed astrocytes suppress tumour-specific T cell immunity pp. 219-229

Camilo Faust Akl, Brian M. Andersen, Zhaorong Li, Federico Giovannoni, Martin Diebold, Liliana M. Sanmarco, Michael Kilian, Luca Fehrenbacher, Florian Pernin, Joseph M. Rone, Hong-Gyun Lee, Gavin Piester, Jessica E. Kenison, Joon-Hyuk Lee, Tomer Illouz, Carolina M. Polonio, Léna Srun, Jazmin Martinez, Elizabeth N. Chung, Anton Schüle, Agustin Plasencia, Lucinda Li, Kylynne Ferrara, Mercedes Lewandrowski, Craig A. Strathdee, Lorena Lerner, Christophe Quéva, Iain C. Clark, Benjamin Deneen, Judy Lieberman, David H. Sherr, Jack P. Antel, Michael A. Wheeler, Keith L. Ligon, E. Antonio Chiocca, Marco Prinz, David A. Reardon and Francisco J. Quintana

Geographic and age variations in mutational processes in colorectal cancer pp. 230-240

Marcos Díaz-Gay, Wellington Santos, Sarah Moody, Mariya Kazachkova, Ammal Abbasi, Christopher D. Steele, Raviteja Vangara, Sergey Senkin, Jingwei Wang, Stephen Fitzgerald, Erik N. Bergstrom, Azhar Khandekar, Burçak Otlu, Behnoush Abedi-Ardekani, Ana Carolina Carvalho, Thomas Cattiaux, Ricardo Cortez Cardoso Penha, Valérie Gaborieau, Priscilia Chopard, Christine Carreira, Saamin Cheema, Calli Latimer, Jon W. Teague, Anush Mukeriya, David Zaridze, Riley Cox, Monique Albert, Larry Phouthavongsy, Steven Gallinger, Reza Malekzadeh, Ahmadreza Niavarani, Marko Miladinov, Katarina Erić, Sasa Milosavljevic, Suleeporn Sangrajrang, Maria Paula Curado, Samuel Aguiar, Rui Manuel Reis, Monise Tadin Reis, Luis Gustavo Romagnolo, Denise Peixoto Guimarães, Ivana Holcatova, Jaroslav Kalvach, Carlos Alberto Vaccaro, Tamara Alejandra Piñero, Beata Świątkowska, Jolanta Lissowska, Katarzyna Roszkowska-Purska, Antonio Huertas-Salgado, Tatsuhiro Shibata, Satoshi Shiba, Surasak Sangkhathat, Taned Chitapanarux, Gholamreza Roshandel, Patricia Ashton-Prolla, Daniel C. Damin, Francine Hehn Oliveira, Laura Humphreys, Trevor D. Lawley, Sandra Perdomo, Michael R. Stratton, Paul Brennan and Ludmil B. Alexandrov

Programmable control of spatial transcriptome in live cells and neurons pp. 241-251

Mengting Han, Maylin L. Fu, Yanyu Zhu, Alexander A. Choi, Emmy Li, Jon Bezney, Sa Cai, Leann Miles, Yitong Ma and Lei S. Qi

EndoMAP.v1 charts the structural landscape of human early endosome complexes pp. 252-261

Miguel A. Gonzalez-Lozano, Ernst W. Schmid, Enya Miguel Whelan, Yizhi Jiang, Joao A. Paulo, Johannes C. Walter and J. Wade Harper

Maternal iron deficiency causes male-to-female sex reversal in mouse embryos pp. 262-270

Naoki Okashita, Ryo Maeda, Shunsuke Kuroki, Kyona Sasaki, Yoko Uno, Peter Koopman and Makoto Tachibana

Substrate recognition and cleavage mechanism of the monkeypox virus core protease pp. 271-279

Yan Gao, Xiong Xie, Xiaoyu Zhang, Junyuan Cao, Weiqi Lan, Tian You, Dongxu Li, Xuxue Dong, Wenhao Dai, Yingchun Xiang, Shulei Hu, Weijuan Shang, Botao Wu, Yumin Zhang, Jin Xu, Xiaoce Liu, Haofeng Wang, Wanlong Hu, Mingjing Zhang, Yinkai Duan, Wen Cui, Hao Zhou, Shengjiang Mao, Handi Jia, Zhanqi Sun, Menghan Jia, Yue Yin, Henry C. Nguyen, Kailin Yang, Bei Yang, Xiuna Yang, Xiaoyun Ji, Gengfu Xiao, Wei Wang, Leike Zhang, Zihe Rao, Hong Liu and Haitao Yang

Effect of phosphorylation barcodes on arrestin binding to a chemokine receptor pp. 280-287

Qiuyan Chen, Christopher T. Schafer, Somnath Mukherjee, Kai Wang, Martin Gustavsson, James R. Fuller, Katelyn Tepper, Thomas D. Lamme, Yasmin Aydin, Parth Agrawal, Genki Terashi, Xin-Qiu Yao, Daisuke Kihara, Anthony A. Kossiakoff, Tracy M. Handel and John J. G. Tesmer

Some US researchers want to leave the country. Can Europe take them? pp. 289-291

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’We couldn’t live without it’: the UCSC Genome Browser turns 25 pp. 292-294

Michael Eisenstein

I pioneered my country’s newborn health-screening programme pp. 296-296

James Mitchell Crow