Synthesis, Anti-Inflammatory, Analgesic, Molecular Modeling and Admet Studies of Novel Diclofenac Derivatives Containing Leucinyl Moiety

Elhenawy A.a, M. A El-Gazzar, H. M Mohmoud, W. I El-Eraky and S.A. W El-Awdan

International Journal of Chemistry and Materials Research, 2013, vol. 1, issue 1, 1-13

Abstract: The present work aims to synthesize novel diclofenac derivatives containing L-leucine moiety. The synthesized compounds docked into the active site to discover validated inhibitors of cyclooxygenases (COX-1 and COX-2). The calculations in-silico were predicted that, the compound with lowest energy of docked poses was interacted with residues of active site, perhaps could be making them possible selective inhibitors against (COX-2) and physiologically active. The binding score of compound compared with reference drug, and show extensive interactions with the targets, which may consider it a suitable selective inhibitor against (COX-2).

Keywords: Leucine; Diclofenac; Cox; Docking; Admet (search for similar items in EconPapers)
Date: 2013
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