Synthesis and Antibacterial Activity of Some Novel N,N-Di-Oxalamide Derivatives

Maha Habash, Mohammad Yasin Mohammad, Manal Ayyash and Mutasem O Taha

International Journal of Chemistry and Materials Research, 2015, vol. 3, issue 12, 165-175

Abstract: Novel N,N-di-oxalamide derivatives 1-6 were synthesized and characterized by the spectroscopic techniques. These derivatives showed good antibacterial activities against Gram-negative organism Escherichia coli and Gram-positive organisms Staphylococcus aureus and Bacillus subtilus. However, compounds 3 and 4 showed potent antibacterial activity against Gram-negative organism Escherichia coliand Gram-positive organism Staphylococcus aureus. In addition to that, we compared their antibacterial profiles with previously synthesized N,N-di-oxalamide derivatives 7-9. The new compounds showed superior antibacterial activities compared to moderate activities for 7-9.

Keywords: N; N-Di-oxalamide derivatives. Escherichia coli; Staphylococcus aureus; Bacillus subtilus; Antibacterial activity; Sulfonamide derivatives (search for similar items in EconPapers)
Date: 2015
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