Gene Expression during the Cell Cycle: Obfuscation of Original Cell-Cycle Gene Expression Data by Normalization

Stephen Cooper

Journal of Cells, 2015, vol. 1, issue 1, 1-7

Abstract: Normalization of raw data on gene expression during the cell cycle obscures the original experimental data and makes it appear as if all genes have the same numerical level of cyclical expression. Results that would not support gene expression because of minimal variations thus appear, after normalization, to be stronger than they actually are. Consideration of the effect of normalization raises critical questions about many experiments on the cell cycle dependent variation of gene expression—that is, proposed cyclical changes in mRNA content—during the cell cycle.

Keywords: Cell-cycle; Normalization; Gene expression; mRNA synthesis (search for similar items in EconPapers)
Date: 2015
References: Add references at CitEc
Citations:

Downloads: (external link)
https://archive.conscientiabeam.com/index.php/97/article/view/2399/3628 (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:pkp:joucel:v:1:y:2015:i:1:p:1-7:id:2399

Access Statistics for this article

More articles in Journal of Cells from Conscientia Beam
Bibliographic data for series maintained by Dim Michael ().