Effects of Vitamin B12 and E on Lipid Profile of Male Wistar Albino Rats Infected with Trypanosomabrucei Infection

Adebayo Olugbenga Adegoke (), Ibitoroko Maureen George Opuda () and Ifunaya B Ekweozoh ()

The International Journal of Biotechnology, 2021, vol. 10, issue 1, 23-30

Abstract: This study was carried out to determine the effect of vitamin B12 and E on the lipid profile of male Wistar albino rats infected with Trypanosomabruceibrucei. 72 male Wistar albino rats were divided into Control, Trypanosome infected, Diamenazene treated, vitamin E, vitamin B12 and various combinations of vitamin B12 and vitamin E. The lipid profile indicators like Triglycerides, Total cholesterol, High Density Lipoprotein and Low Density Lipoprotein were determined using enzymatic methods while Low Density Lipoprotein was determined using Friedewald formula. The data was subjected to statistical analysis using Statistical Package for Social Science (SPSS) version 20. There was a significant decrease (p<0.05) in the Triglycerides (mg/dl), Cholesterol (mg/dl), HDL (mg/dl) and LDL (mg/dl) in trypanosome infected group (52.93±2.76, 51.88±2.20, 37.31±0.81 and 28.85±1.78) and diamenazene treated group (77.55±2.42, 56.18±0.89, 35.26±1.00 and 38.38±0.86) respectively when compared to the respective control concentrations (99.03±6.66, 64.83±2.41, 39.87±0.27 and 38.03±2.81).Vitamin B12 (68.08±5.25, 59.44±2.40, 36.61±0.30 and 38.51±2.89), Vitamin E (68.45 + 3.67, 75.19 + 5.27, 39.91 + 1.47 and 45.42 + 3.74) and Vitamin B12 and E combination (73.17 + 1.94, 79.14+ 2.56, 40.57 + 0.97 and 58.96 + 2.25) showed a significant increase (p<0.05) in the mean concentrations of Triglycerides (mg/dl), Cholesterol (mg/dl), HDL (mg/dl) and a significant increase in LDL (mg/dl) respectively when compared to the trypanosome infected group (52.93±2.76, 51.88±2.20, 37.31±0.81 and 28.85±1.78).The result suggested that oral administration of vitamin B12 and E reversed the changes induced by Trypanosoma brucei brucei infection in Triglycerides, Cholesterol, High Density Lipoprotein and Low Density Lipoprotein.

Keywords: Vitamin B12; Vitamin E; Lipid; Trypanosomiasis (search for similar items in EconPapers)
Date: 2021
References: Add references at CitEc
Citations:

Downloads: (external link)
https://archive.conscientiabeam.com/index.php/57/article/view/1576/2191 (application/pdf)
https://archive.conscientiabeam.com/index.php/57/article/view/1576/4619 (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:pkp:tijobi:v:10:y:2021:i:1:p:23-30:id:1576

Access Statistics for this article

More articles in The International Journal of Biotechnology from Conscientia Beam
Bibliographic data for series maintained by Dim Michael ().