Lactic Acid as Spacer between Poly Acrylic Acid and 4-Aminoantipyrine

Fiyral Mohammad Ali, Taghreed Hashim AL-Noor and Saif Mohsin Ali

The International Journal of Biotechnology, 2015, vol. 4, issue 6, 36-45

Abstract: Due to many problems associated with drug release and side effects, we could design a novel drug delivery system through modification of poly acrylic acid (AA) with Lactic acid as a spacer between the polymer and 4-aminoantipyrine. In vitro drug release had been conducted successfully in basic medium in pH 7.4 and acidic medium in pH 1.1 at 37℃. The prepared prodrug polymer was characterized by FTIR and 1H−NMR spectra. Physical properties and intrinsic viscosity of drug polymer were determined. The good results were obtained in the presence of spacer unit with comparing without spacer unit.

Keywords: Poly acrylic acid; Lactic acid; Prodrug polymer (search for similar items in EconPapers)
Date: 2015
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