PLOS Biology

2003 - 2025

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Volume 23, issue 12, 2025

Aging-related peroxisomal dysregulation disrupts intestinal stem cell differentiation through alterations of very long-chain fatty acid oxidation pp. 1-25

Xiaoxin Guo, Gang Du, Juanyu Zhou, Fang Fu, Yu Yuan, Xingzhu Liu, Haiou Chen, Qianyi Wan, Bo Gong and Haiyang Chen

From pipeline to network: We need to redefine scientific success pp. 1-5

Alexandra A-T Weber

Prolonged starvation deepens quiescence in Vasa2/Piwi1-expressing cells of a sea anemone pp. 1-30

Eudald Pascual-Carreras, Kathrin Garschall and Patrick R H Steinmetz

Most researchers would receive more recognition if assessed by article-level metrics than by journal-level metrics pp. 1-18

Salsabil Arabi, Chaoqun Ni and B Ian Hutchins

A metabolic atlas of the Klebsiella pneumoniae species complex reveals lineage-specific metabolism and capacity for intra-species co-operation pp. 1-22

Ben Vezina, Helena B Cooper, Christopher K Barlow, Martin Rethoret-Pasty, Sylvain Brisse, Jonathan M Monk, Kathryn E Holt and Kelly L Wyres

Structures of G-protein coupled receptor HCAR3 in complex with selective agonists reveal the basis for ligand recognition and selectivity pp. 1-20

Fang Ye, Zhiyi Zhang, Binghao Zhang, Xinyu Li, Jiaxi Deng, Qian Miao, Peiruo Ning, Yunlin Chi, Geng Chen, Zhangsong Wu, Qian Wang, Lezhi Xu, Ningjie Gong, Bangning Cheng, Zhigang Ma, Chungen Qian, Lizhe Zhu, Xin Pan and Yang Du

The transcription factor SKN-1 drives lysosomal enlargement during aging to maintain function pp. 1-20

Xinyu Wang, Huimin Liu, Xiaoman Wang, Ben Zhou, Haiqing Tang and Shanshan Pang

Control of mitochondrial dynamics by the metabolic regulator dPGC1 limits Yorkie-induced oncogenic growth in Drosophila pp. 1-34

Wei Qi Guinevere Sew, Maria Molano-Fernández, Zhiquan Li, Artim Lange, Nahia Pérez de Ciriza, Lene Juel Rasmussen and Hector Herranz

Volume 23, issue 11, 2025

Environmental noise-induced changes to the IC-SNc circuit promotes motor deficits and neuronal vulnerability in a mouse model of Parkinson’s Disease pp. 1-28

Chi Cui, Yibo Yao, Yulong Shi, Jie Lei, Kun Ren, Kexing Wan, Tongxia Li, Gangan Luo, Qian Xu, Ming Li, Xiang Peng, Xueke Yang, Jian Yang, Junsong Du, Sitong Chen, Bo Tian and Pei Zhang

Efficient and reliable spike sorting from neural recordings with UMAP-based unsupervised nonlinear dimensionality reduction pp. 1-28

Daniel Suárez-Barrera, Lucas Bayones, Norberto Encinas-Rodríguez, Sergio Parra, Viktor Monroy, Sebastián Pujalte, Bernardo Andrade-Ortega, Héctor Díaz, Manuel Alvarez, Antonio Zainos, Alessio Franci and Román Rossi-Pool

The blood–brain barrier regulates brain tumor growth through the SLC36 amino acid transporter Pathetic in Drosophila pp. 1-31

Qian Dong, Edel Alvarez-Ochoa, Phuong-Khanh Nguyen, Paul Orih, Natasha Fahey-Lozano, Hina Kosakamoto, Fumiaki Obata, Cyrille Alexandre and Louise Y Cheng

Volume 23, issue 10, 2025

eDNA surveys substantially expand known geographic and ecological niche boundaries of marine fishes pp. 1-22

Loïc Sanchez, Nicolas Loiseau, Camille Albouy, Morgane Bruno, Adèle Barroil, Alicia Dalongeville, Julie Deter, Jean-Dominique Durand, Nadia Faure, Fabian Fopp, Régis Hocdé, Mélissa Jaquier, Narriman S Jiddawi, Meret Jucker, Jean-Baptiste Juhel, Kadarusman, Virginie Marques, Laëtitia Mathon, David Mouillot, Marie Orblin, Loïc Pellissier, Raphaël Seguin, Hagi Yulia Sugeha, Alice Valentini, Laure Velez, Indra Bayu Vimono, Fabien Leprieur and Stéphanie Manel

Human brain integrates both unconditional and conditional timing statistics to guide expectation and behavior pp. 1-22

Yiyuan Teresa Huang and Zenas C Chao

Identification of five sleep-biopsychosocial profiles with specific neural signatures linking sleep variability with health, cognition, and lifestyle factors pp. 1-26

Aurore A Perrault, Valeria Kebets, Nicole M Y Kuek, Nathan E Cross, Rackeb Tesfaye, Florence B Pomares, Jingwei Li, Michael W L Chee, Thien Thanh Dang-Vu and B T Thomas Yeo

Nicotine induces abnormal motor coupling through sensitization of a mechanosensory circuit in Caenorhabditis elegans pp. 1-27

Yuting Liu, Leiru Huang, Ruipeng Wang, Fukang Qi, Yiwen Liu, Qingyuan Chen, Morgane Mialon, Lili Chen, Berangere Pinan-Lucarre and Shangbang Gao

When goodbye comes too soon: How to wrap up science projects quickly pp. 1-5

Megan Hastings Hagenauer, Stacey J Winham, Alexandra L J Freeman, Paul W Sternberg and Benedict J Kolber

Distinct alpha networks modulate different aspects of perceptual decision-making pp. 1-16

Ying Joey Zhou, Mats W J van Es and Saskia Haegens

Volume 23, issue 9, 2025

The mTORC2 subunit RICTOR drives breast cancer progression by promoting ganglioside biosynthesis through transcriptional and epigenetic mechanisms pp. 1-35

Mohammad Nafees Ansari, Somesh K Jha, Ali Khan, Kajal Rajput, Nishant Pandey, Dolly Jain, Rajeshwari Tripathi, Nihal Medatwal, Pankaj Sharma, Sudeshna Datta, Animesh Kar, Trishna Pani, Sk Asif Ali, Kaushavi Cholke, Kajal Rana, Valiya P Snijesh, Geetashree Mukherjee, Suryanarayana V S Deo, Soumen Basak, Ashutosh Mishra, Jyothi S Prabhu, Arnab Mukhopadhyay, Avinash Bajaj and Ujjaini Dasgupta

Ending publication bias: A values-based approach to surface null and negative results pp. 1-10

Stephen Curry, Eunice Mercado-Lara, Virginia Arechavala-Gomeza, C Glenn Begley, Christophe Bernard, René Bernard, Stefano Bertuzzi, Needhi Bhalla, Dawn Bowers, Samuel Brod, Christopher Chambers, Michael R Dougherty, Yensi Flores Bueso, Stefânia Forner, Alexandra L J Freeman, Magali Haas, Darla P Henderson, Kanika Khanna, Rebecca Lawrence, Kif Liakath-Ali, Christine Liu, Neil Malhotra, José G Merino, Edward Miguel, Rachel Miles, Mary Munson, Shinichi Nakagawa, Robert Nobles, Joy Owango, Michel Tuan Pham, Gina Poe, Alexandra N Ramirez, Sarvenaz Sarabipour, Jill L Silverman, Laura N Smith, P Sriramarao, Paul W Sternberg, Geeta K Swamy, Malú Gámez Tansey, Gonzalo E Torres, Erick H Turner, Lauren von Klinggraeff and Frances Weis-Garcia

Extinction and subsequent updating of innate fear responses to a visual looming stimulus rely on hippocampus-dependent mechanisms pp. 1-19

Paul B Conway, Livia Autore, Andrea Muñoz Zamora, Antoine Harel, Zijun Wang, Armn A Tavallaei, Stephen M Winston, Clara Ortega- de San Luis, James D O’Leary, Mark A Brimble, Gisella Vetere and Tomás J Ryan

Recent extinctions of plant and animal genera are rare, localized, and decelerated pp. 1-17

John J Wiens and Kristen E Saban

Transformative change to address biodiversity loss is urgent and possible pp. 1-4

Anne Larigauderie, Karen O’Brien, Lucas A Garibaldi and Arun Agrawal

Developmental auditory deprivation in one ear impairs brainstem binaural processing and reduces spatial hearing acuity pp. 1-34

Kelsey L Anbuhl, Alexander T Ferber, Andrew D Brown, Victor Benichoux, Nathaniel T Greene and Daniel J Tollin

Continuous monitoring and machine vision reveals that developing gerbils exhibit structured social behaviors prior to the emergence of autonomy pp. 1-22

Catalin Mitelut, Marielisa Diez Castro, Ralph E Peterson, Maria Gonçalves, Jennifer Li, Madeline Gamer, Simon RO Nilsson, Talmo D Pereira and Dan H Sanes

Short-term memory errors are strongly associated with a drift in neural activity in the posterior parietal cortex pp. 1-32

Joon Ho Choi, Sungwon Bae, Jiho Park, Minsu Yoo, Chul Hoon Kim, Lukas Ian Schmitt, Youngbin Tchoe, Dongil Chung, Ji-Woong Choi and Jong-Cheol Rah

Language, economic and gender disparities widen the scientific productivity gap pp. 1-13

Tatsuya Amano, Valeria Ramírez-Castañeda, Violeta Berdejo-Espinola, Israel Borokini, Shawan Chowdhury, Marina Golivets, Juan David González-Trujillo, Flavia Montaño-Centellas, Kumar Paudel, Rachel L White and Diogo Veríssimo

Quantitative modeling of multi-signal quorum-sensing maps environment to bacterial regulatory responses pp. 1-18

Stephen Thomas, Ayatollah S El-Zayat, James Gurney, Jennifer Rattray and Sam P Brown

Volume 23, issue 8, 2025

Mitochondrial ROS and HIF-1α signaling mediate synaptic plasticity in the critical period pp. 1-26

Daniel Sobrido-Cameán, Bramwell Coulson, Michael Miller, Matthew C W Oswald, Tom Pettini, David M D Bailey, Richard A Baines and Matthias Landgraf

Recurrence affects the geometry of visual representations across the ventral visual stream in the human brain pp. 1-30

Siying Xie, Johannes Singer, Bati Yilmaz, Daniel Kaiser and Radoslaw M Cichy

The prefrontal cortex encodes task-identity information and flexibly adjusts its sensory processes as a function of the specific ongoing task pp. 1-25

A Mouille, C Gaillard, E Astrand, C Wardak, Amengual Jl and S Ben Hamed

Compare first, evaluate later: Upending the neuroscience of choice pp. 1-4

Benjamin Y Hayden

Flexible competency framework: A tool for optimizing life science training pp. 1-6

Xiuqi Li, Jelena Patrnogić and David Van Vactor

Active DNA demethylation upstream of rod-photoreceptor fate determination is required for retinal development pp. 1-36

Ismael Hernández-Núñez, Alaina Urman, Xiaodong Zhang, William Jacobs, Christy Hoffmann, Ellen G Harding, Shiming Chen, Meelad M Dawlaty, Philip A Ruzycki, John R Edwards and Brian S Clark

Volume 23, issue 7, 2025

Goal-directed navigation in humans and deep reinforcement learning agents relies on an adaptive mix of vector-based and transition-based strategies pp. 1-33

Denis C L Lan, Laurence T Hunt and Christopher Summerfield

Mediator complex subunit MED23 dampens antiviral innate immunity by restricting RIG-I expression pp. 1-21

Xiong De-fei, Yi-yang Zhang, Zhi-chao Wang, Yuan-ming Zheng, Han-qing Zhang and Gang Wang

Wakefulness can be distinguished from general anesthesia and sleep in flies using a massive library of univariate time series analyses pp. 1-32

Angus Leung, Ahmed Mahmoud, Travis Jeans, Ben D Fulcher, Bruno van Swinderen and Naotsugu Tsuchiya

Mapping cerebral blood perfusion and its links to multi-scale brain organization across the human lifespan pp. 1-43

Asa Farahani, Zhen-Qi Liu, Eric G Ceballos, Justine Y Hansen, Karl Wennberg, Yashar Zeighami, Mahsa Dadar, Claudine J Gauthier, Alain Dagher and Bratislav Misic

Personalised regional modelling predicts tau progression in the human brain pp. 1-25

Pavanjit Chaggar, Jacob Vogel, Alexa Pichet Binette, Travis B Thompson, Olof Strandberg, Niklas Mattsson-Carlgren, Linda Karlsson, Erik Stomrud, Saad Jbabdi, Stefano Magon, Gregory Klein, with the Alzheimer’s Disease Neuroimaging Initiative, Oskar Hansson and Alain Goriely

Challenges and opportunities for the next generation of computational tumor models pp. 1-4

Lance L Munn and Rakesh K Jain

Omics datasets can bridge the gap between tumor biology and patient care pp. 1-4

Ji-Ting Huang, Lei-Jie Dai, Ding Ma and Zhi-Ming Shao

H3K4me2 distinguishes a distinct class of enhancers during the maternal-to-zygotic transition pp. 1-27

Matthew D Hurton, Jennifer M Miller and Miler T Lee

Volume 23, issue 6, 2025

Human attention-guided visual perception is governed by rhythmic oscillations and aperiodic timescales pp. 1-18

Isabel Raposo, Ian C Fiebelkorn, Jack J Lin, Josef Parvizi, Sabine Kastner, Robert T Knight, Assaf Breska and Randolph F Helfrich

The fifth era of science: Artificial scientific intelligence pp. 1-4

Nina Miolane

Too poor to science: How wealth determines who succeeds in STEM pp. 1-4

Craig R McClain

Adaptive landscapes unveil the complex evolutionary path from sprawling to upright forelimb function and posture in mammals pp. 1-27

Robert J Brocklehurst, Magdalen Mercado, Kenneth D Angielczyk and Stephanie E Pierce

Precise spike-timing information in the brainstem is well aligned with the needs of communication and the perception of environmental sounds pp. 1-33

Chris Scholes, Stephen Coombes, Alan R Palmer, William S Rhode, Rob Mill and Christian J Sumner

Using anti-DEI policies to dismantle education: A new front in a really old battle pp. 1-3

Cissy J Ballen, Terry McGlynn and Kelly R Zamudio

Gnb5 is a negative regulator of the BACE1-mediated Aβ generation and ameliorates cognitive deficits in a mouse model of Alzheimer’s disease pp. 1-21

Shaokun Chen, Jiechao Zhou, Shuzhong Wang, Erqu Chen, Kai Zhuang, Raozhou Lin, Chensi Liang, Dan Can, Huifang Li, Jing Li and Jie Zhang

Volume 23, issue 5, 2025

Predictable motion is progressively extrapolated across temporally distinct processing stages in the human visual cortex pp. 1-23

William Turner, Charlie Sexton, Philippa A Johnson, Ella Wilson and Hinze Hogendoorn

Is pathogen prediction possible? pp. 1-4

Arturo Casadevall

More science friction for less science fiction pp. 1-4

Jennifer A Byrne and Stefan Stender

Rewarding animals based on their subjective percepts is enabled by online Bayesian estimation of perceptual biases pp. 1-37

Yelin Dong, Gabor Lengyel, Sabyasachi Shivkumar, Akiyuki Anzai, Grace F DiRisio, Ralf M Haefner and Gregory C DeAngelis

Loss of neuropeptidergic regulation of cholinergic transmission induces homeostatic compensation in muscle cells to preserve synaptic strength pp. 1-29

Jiajie Shao, Jana F Liewald, Wagner Steuer Costa, Christiane Ruse, Jens Gruber, Mohammad S Djamshedzad, Wulf Gebhardt and Alexander Gottschalk

Explosion of formulaic research articles, including inappropriate study designs and false discoveries, based on the NHANES US national health database pp. 1-15

Tulsi Suchak, Anietie E Aliu, Charlie Harrison, Reyer Zwiggelaar, Nophar Geifman and Matt Spick

Volume 23, issue 4, 2025

Removing facial features from structural MRI images biases visual quality assessment pp. 1-19

Céline Provins, Élodie Savary, Thomas Sanchez, Emeline Mullier, Jaime Barranco, Elda Fischi-Gómez, Yasser Alemán-Gómez, Jonas Richiardi, Russell A Poldrack, Patric Hagmann and Oscar Esteban

Werner syndrome exonuclease promotes gut regeneration and causes age-associated gut hyperplasia in Drosophila pp. 1-34

Kun Wu, Juanyu Zhou, Yiming Tang, Qiaoqiao Zhang, Lishou Xiong, Xiaorong Li, Zhangpeng Zhuo, Mei Luo, Yu Yuan, Xingzhu Liu, Zhendong Zhong, XiaoXin Guo, Zihua Yu, Xiao Sheng, Guanzheng Luo and Haiyang Chen

Autophagy-related protein Atg11 is essential for microtubule-mediated chromosome segregation pp. 1-38

Md Hashim Reza, Rashi Aggarwal, Jigyasa Verma, Nitesh Kumar Podh, Ratul Chowdhury, Gunjan Mehta, Ravi Manjithaya and Kaustuv Sanyal

Volume 23, issue 3, 2025

On improving the sustainability of peer review pp. 1-3

Daniel Routledge, Nonia Pariente and On Behalf of the PLOS Biology Staff Editors

The IBEX Knowledge-Base: A central resource for multiplexed imaging techniques pp. 1-7

Andrea J Radtke, Ifeanyichukwu U Anidi, Leanne Arakkal, Armando J Arroyo-Mejias, Rebecca T Beuschel, Katy Börner, Colin J Chu, Beatrice Clark, Menna R Clatworthy, Jake Colautti, Fabian Coscia, Joshua Croteau, Saven Denha, Rose Dever, Walderez O Dutra, Sonja Fritzsche, Spencer Fullam, Michael Y Gerner, Anita Gola, Kenneth J Gollob, Jonathan M Hernandez, Jyh Liang Hor, Hiroshi Ichise, Zhixin Jing, Danny Jonigk, Evelyn Kandov, Wolfgang Kastenmüller, Joshua F E Koenig, Rosa K Kortekaas, Aanandita Kothurkar, Alexandra Y Kreins, Ian T Lamborn, Yuri Lin, Katia Luciano Pereira Morais, Aleksandra Lunich, Jean C S Luz, Ryan B MacDonald, Chen Makranz, Vivien I Maltez, John E McDonough, Ryan V Moriarty, Juan M Ocampo-Godinez, Vitoria M Olyntho, Annette Oxenius, Kartika Padhan, Kirsten Remmert, Nathan Richoz, Edward C Schrom, Wanjing Shang, Lihong Shi, Rochelle M Shih, Emily Speranza, Salome Stierli, Sarah A Teichmann, Tibor Z Veres, Megan Vierhout, Brianna T Wachter, Adam K Wade-Vallance, Margaret Williams, Nathan Zangger, Ronald N Germain and Ziv Yaniv

Navigating your US bioscience career into the 2030s pp. 1-4

Peter J Hotez

Navigation strategies in Caenorhabditis elegans are differentially altered by learning pp. 1-24

Kevin S Chen, Anuj K Sharma, Jonathan W Pillow and Andrew M Leifer

Volume 23, issue 2, 2025

New solutions for antibiotic discovery: Prioritizing microbial biosynthetic space using ecology and machine learning pp. 1-3

Marnix H Medema and Gilles P van Wezel

vmTracking enables highly accurate multi-animal pose tracking in crowded environments pp. 1-44

Hirotsugu Azechi and Susumu Takahashi

Volume 23, issue 1, 2025

How can modeling responsibly inform decision-making in malaria? pp. 1-5

Jaline Gerardin and Melissa A Penny

Cost-benefit tradeoff mediates the transition from rule-based to memory-based processing during practice pp. 1-24

Guochun Yang and Jiefeng Jiang

Spontaneous slow cortical potentials and brain oscillations independently influence conscious visual perception pp. 1-33

Lua Koenig and Biyu J He