PLOS Biology

2003 - 2025

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Volume 23, issue 8, 2025

Active DNA demethylation upstream of rod-photoreceptor fate determination is required for retinal development pp. 1-36

Ismael Hernández-Núñez, Alaina Urman, Xiaodong Zhang, William Jacobs, Christy Hoffmann, Ellen G Harding, Shiming Chen, Meelad M Dawlaty, Philip A Ruzycki, John R Edwards and Brian S Clark

Mitochondrial ROS and HIF-1α signaling mediate synaptic plasticity in the critical period pp. 1-26

Daniel Sobrido-Cameán, Bramwell Coulson, Michael Miller, Matthew C W Oswald, Tom Pettini, David M D Bailey, Richard A Baines and Matthias Landgraf

Compare first, evaluate later: Upending the neuroscience of choice pp. 1-4

Benjamin Y Hayden

Volume 23, issue 7, 2025

Challenges and opportunities for the next generation of computational tumor models pp. 1-4

Lance L Munn and Rakesh K Jain

Omics datasets can bridge the gap between tumor biology and patient care pp. 1-4

Ji-Ting Huang, Lei-Jie Dai, Ding Ma and Zhi-Ming Shao

Mapping cerebral blood perfusion and its links to multi-scale brain organization across the human lifespan pp. 1-43

Asa Farahani, Zhen-Qi Liu, Eric G Ceballos, Justine Y Hansen, Karl Wennberg, Yashar Zeighami, Mahsa Dadar, Claudine J Gauthier, Alain Dagher and Bratislav Misic

Goal-directed navigation in humans and deep reinforcement learning agents relies on an adaptive mix of vector-based and transition-based strategies pp. 1-33

Denis C L Lan, Laurence T Hunt and Christopher Summerfield

Personalised regional modelling predicts tau progression in the human brain pp. 1-25

Pavanjit Chaggar, Jacob Vogel, Alexa Pichet Binette, Travis B Thompson, Olof Strandberg, Niklas Mattsson-Carlgren, Linda Karlsson, Erik Stomrud, Saad Jbabdi, Stefano Magon, Gregory Klein, with the Alzheimer’s Disease Neuroimaging Initiative, Oskar Hansson and Alain Goriely

H3K4me2 distinguishes a distinct class of enhancers during the maternal-to-zygotic transition pp. 1-27

Matthew D Hurton, Jennifer M Miller and Miler T Lee

Mediator complex subunit MED23 dampens antiviral innate immunity by restricting RIG-I expression pp. 1-21

Xiong De-fei, Yi-yang Zhang, Zhi-chao Wang, Yuan-ming Zheng, Han-qing Zhang and Gang Wang

Wakefulness can be distinguished from general anesthesia and sleep in flies using a massive library of univariate time series analyses pp. 1-32

Angus Leung, Ahmed Mahmoud, Travis Jeans, Ben D Fulcher, Bruno van Swinderen and Naotsugu Tsuchiya

Volume 23, issue 6, 2025

Gnb5 is a negative regulator of the BACE1-mediated Aβ generation and ameliorates cognitive deficits in a mouse model of Alzheimer’s disease pp. 1-21

Shaokun Chen, Jiechao Zhou, Shuzhong Wang, Erqu Chen, Kai Zhuang, Raozhou Lin, Chensi Liang, Dan Can, Huifang Li, Jing Li and Jie Zhang

Human attention-guided visual perception is governed by rhythmic oscillations and aperiodic timescales pp. 1-18

Isabel Raposo, Ian C Fiebelkorn, Jack J Lin, Josef Parvizi, Sabine Kastner, Robert T Knight, Assaf Breska and Randolph F Helfrich

Precise spike-timing information in the brainstem is well aligned with the needs of communication and the perception of environmental sounds pp. 1-33

Chris Scholes, Stephen Coombes, Alan R Palmer, William S Rhode, Rob Mill and Christian J Sumner

Adaptive landscapes unveil the complex evolutionary path from sprawling to upright forelimb function and posture in mammals pp. 1-27

Robert J Brocklehurst, Magdalen Mercado, Kenneth D Angielczyk and Stephanie E Pierce

Using anti-DEI policies to dismantle education: A new front in a really old battle pp. 1-3

Cissy J Ballen, Terry McGlynn and Kelly R Zamudio

The fifth era of science: Artificial scientific intelligence pp. 1-4

Nina Miolane

Too poor to science: How wealth determines who succeeds in STEM pp. 1-4

Craig R McClain

Volume 23, issue 5, 2025

Loss of neuropeptidergic regulation of cholinergic transmission induces homeostatic compensation in muscle cells to preserve synaptic strength pp. 1-29

Jiajie Shao, Jana F Liewald, Wagner Steuer Costa, Christiane Ruse, Jens Gruber, Mohammad S Djamshedzad, Wulf Gebhardt and Alexander Gottschalk

Predictable motion is progressively extrapolated across temporally distinct processing stages in the human visual cortex pp. 1-23

William Turner, Charlie Sexton, Philippa A Johnson, Ella Wilson and Hinze Hogendoorn

Rewarding animals based on their subjective percepts is enabled by online Bayesian estimation of perceptual biases pp. 1-37

Yelin Dong, Gabor Lengyel, Sabyasachi Shivkumar, Akiyuki Anzai, Grace F DiRisio, Ralf M Haefner and Gregory C DeAngelis

Is pathogen prediction possible? pp. 1-4

Arturo Casadevall

More science friction for less science fiction pp. 1-4

Jennifer A Byrne and Stefan Stender

Explosion of formulaic research articles, including inappropriate study designs and false discoveries, based on the NHANES US national health database pp. 1-15

Tulsi Suchak, Anietie E Aliu, Charlie Harrison, Reyer Zwiggelaar, Nophar Geifman and Matt Spick

Volume 23, issue 4, 2025

Werner syndrome exonuclease promotes gut regeneration and causes age-associated gut hyperplasia in Drosophila pp. 1-34

Kun Wu, Juanyu Zhou, Yiming Tang, Qiaoqiao Zhang, Lishou Xiong, Xiaorong Li, Zhangpeng Zhuo, Mei Luo, Yu Yuan, Xingzhu Liu, Zhendong Zhong, XiaoXin Guo, Zihua Yu, Xiao Sheng, Guanzheng Luo and Haiyang Chen

Removing facial features from structural MRI images biases visual quality assessment pp. 1-19

Céline Provins, Élodie Savary, Thomas Sanchez, Emeline Mullier, Jaime Barranco, Elda Fischi-Gómez, Yasser Alemán-Gómez, Jonas Richiardi, Russell A Poldrack, Patric Hagmann and Oscar Esteban

Autophagy-related protein Atg11 is essential for microtubule-mediated chromosome segregation pp. 1-38

Md Hashim Reza, Rashi Aggarwal, Jigyasa Verma, Nitesh Kumar Podh, Ratul Chowdhury, Gunjan Mehta, Ravi Manjithaya and Kaustuv Sanyal

Volume 23, issue 3, 2025

Navigation strategies in Caenorhabditis elegans are differentially altered by learning pp. 1-24

Kevin S Chen, Anuj K Sharma, Jonathan W Pillow and Andrew M Leifer

The IBEX Knowledge-Base: A central resource for multiplexed imaging techniques pp. 1-7

Andrea J Radtke, Ifeanyichukwu U Anidi, Leanne Arakkal, Armando J Arroyo-Mejias, Rebecca T Beuschel, Katy Börner, Colin J Chu, Beatrice Clark, Menna R Clatworthy, Jake Colautti, Fabian Coscia, Joshua Croteau, Saven Denha, Rose Dever, Walderez O Dutra, Sonja Fritzsche, Spencer Fullam, Michael Y Gerner, Anita Gola, Kenneth J Gollob, Jonathan M Hernandez, Jyh Liang Hor, Hiroshi Ichise, Zhixin Jing, Danny Jonigk, Evelyn Kandov, Wolfgang Kastenmüller, Joshua F E Koenig, Rosa K Kortekaas, Aanandita Kothurkar, Alexandra Y Kreins, Ian T Lamborn, Yuri Lin, Katia Luciano Pereira Morais, Aleksandra Lunich, Jean C S Luz, Ryan B MacDonald, Chen Makranz, Vivien I Maltez, John E McDonough, Ryan V Moriarty, Juan M Ocampo-Godinez, Vitoria M Olyntho, Annette Oxenius, Kartika Padhan, Kirsten Remmert, Nathan Richoz, Edward C Schrom, Wanjing Shang, Lihong Shi, Rochelle M Shih, Emily Speranza, Salome Stierli, Sarah A Teichmann, Tibor Z Veres, Megan Vierhout, Brianna T Wachter, Adam K Wade-Vallance, Margaret Williams, Nathan Zangger, Ronald N Germain and Ziv Yaniv

On improving the sustainability of peer review pp. 1-3

Daniel Routledge, Nonia Pariente and On Behalf of the PLOS Biology Staff Editors

Navigating your US bioscience career into the 2030s pp. 1-4

Peter J Hotez

Volume 23, issue 2, 2025

vmTracking enables highly accurate multi-animal pose tracking in crowded environments pp. 1-44

Hirotsugu Azechi and Susumu Takahashi

New solutions for antibiotic discovery: Prioritizing microbial biosynthetic space using ecology and machine learning pp. 1-3

Marnix H Medema and Gilles P van Wezel

Volume 23, issue 1, 2025

How can modeling responsibly inform decision-making in malaria? pp. 1-5

Jaline Gerardin and Melissa A Penny

Cost-benefit tradeoff mediates the transition from rule-based to memory-based processing during practice pp. 1-24

Guochun Yang and Jiefeng Jiang

Spontaneous slow cortical potentials and brain oscillations independently influence conscious visual perception pp. 1-33

Lua Koenig and Biyu J He

Volume 22, issue 12, 2024

Distinct patterns of connectivity with the motor cortex reflect different components of sensorimotor learning pp. 1-33

Corson N Areshenkoff, Anouk J de Brouwer, Daniel J Gale, Joseph Y Nashed, Jonathan Smallwood, J Randall Flanagan and Jason P Gallivan

Hyperspectral imaging in animal coloration research: A user-friendly pipeline for image generation, analysis, and integration with 3D modeling pp. 1-27

Benedict G Hogan and Mary Caswell Stoddard

The thalamus encodes and updates context representations during hierarchical cognitive control pp. 1-28

Xitong Chen, Stephanie C Leach, Juniper Hollis, Dillan Cellier and Kai Hwang

Postingestive reward acts through behavioral reinforcement and is conserved in obesity and after bariatric surgery pp. 1-23

Gabriela Ribeiro, Ana B Fernandes, Francisco P M Oliveira, João S Duarte, Manuela Oliveira, Clotilde Limbert, Rui M Costa, Durval C Costa and Albino J Oliveira-Maia

Meta-analysis of single-cell RNA sequencing co-expression in human neural organoids reveals their high variability in recapitulating primary tissue pp. 1-34

Jonathan M Werner and Jesse Gillis

Volume 22, issue 11, 2024

Reconstructing the last common ancestor of all eukaryotes pp. 1-24

Thomas A Richards, Laura Eme, John M Archibald, Guy Leonard, Susana M Coelho, Alex de Mendoza, Christophe Dessimoz, Pavel Dolezal, Lillian K Fritz-Laylin, Toni Gabaldón, Vladimír Hampl, Geert J P L Kops, Michelle M Leger, Purificacion Lopez-Garcia, James O McInerney, David Moreira, Sergio A Muñoz-Gómez, Daniel J Richter, Iñaki Ruiz-Trillo, Alyson E Santoro, Arnau Sebé-Pedrós, Berend Snel, Courtney W Stairs, Eelco C Tromer, Jolien J E van Hooff, Bill Wickstead, Tom A Williams, Andrew J Roger, Joel B Dacks and Jeremy G Wideman

Stochastic models allow improved inference of microbiome interactions from time series data pp. 1-25

Román Zapién-Campos, Florence Bansept and Arne Traulsen

A call for research to address the threat of paper mills pp. 1-5

Jennifer A Byrne, Anna Abalkina, Olufolake Akinduro-Aje, Jana Christopher, Sarah E Eaton, Nitin Joshi, Ulf Scheffler, Nick H Wise and Jennifer Wright

Biofilm dispersal patterns revealed using far-red fluorogenic probes pp. 1-21

Jojo A Prentice, Sandhya Kasivisweswaran, Robert van de Weerd and Andrew A Bridges

Volume 22, issue 10, 2024

Evolution of sex differences in cooperation can be explained by trade-offs with dispersal pp. 1-27

Pablo Capilla-Lasheras, Nina Bircher, Antony M Brown, Xavier Harrison, Thomas Reed, Jennifer E York, Dominic L Cram, Christian Rutz, Lindsay Walker, Marc Naguib and Andrew J Young

Reviving collapsed plant–pollinator networks from a single species pp. 1-32

Gaurav Baruah and Meike J Wittmann

Unifying approaches from statistical genetics and phylogenetics for mapping phenotypes in structured populations pp. 1-30

Joshua G Schraiber, Michael D Edge and Matt Pennell

Volume 22, issue 9, 2024

A dystroglycan–laminin–integrin axis coordinates cell shape remodeling in the developing Drosophila retina pp. 1-31

Rhian F Walther, Courtney Lancaster, Jemima J Burden and Franck Pichaud

Human brain state dynamics are highly reproducible and associated with neural and behavioral features pp. 1-34

Kangjoo Lee, Jie Lisa Ji, Clara Fonteneau, Lucie Berkovitch, Masih Rahmati, Lining Pan, Grega Repovš, John H Krystal, John D Murray and Alan Anticevic

Functional network modules overlap and are linked to interindividual connectome differences during human brain development pp. 1-30

Tianyuan Lei, Xuhong Liao, Xinyuan Liang, Lianglong Sun, Mingrui Xia, Yunman Xia, Tengda Zhao, Xiaodan Chen, Weiwei Men, Yanpei Wang, Leilei Ma, Ningyu Liu, Jing Lu, Gai Zhao, Yuyin Ding, Yao Deng, Jiali Wang, Rui Chen, Haibo Zhang, Shuping Tan, Jia-Hong Gao, Shaozheng Qin, Sha Tao, Qi Dong and Yong He

Volume 22, issue 8, 2024

The ion channel Anoctamin 10/TMEM16K coordinates organ morphogenesis across scales in the urochordate notochord pp. 1-57

Zonglai Liang, Daniel Christiaan Dondorp and Marios Chatzigeorgiou

A rigorous and versatile statistical test for correlations between stationary time series pp. 1-26

Alex E Yuan and Wenying Shou

Metabolic specialization drives reduced pathogenicity in Pseudomonas aeruginosa isolates from cystic fibrosis patients pp. 1-26

Bjarke Haldrup Pedersen, Filipa Bica Simões, Ivan Pogrebnyakov, Martin Welch, Helle Krogh Johansen, Søren Molin and Ruggero La Rosa

Rationalizing risk aversion in science: Why incentives to work hard clash with incentives to take risks pp. 1-15

Kevin Gross and Carl T Bergstrom

State-dependent connectivity in auditory-reward networks predicts peak pleasure experiences to music pp. 1-30

Kazuma Mori and Robert Zatorre

Volume 22, issue 7, 2024

“Best Paper” awards lack transparency, inclusivity, and support for Open Science pp. 1-20

Malgorzata Lagisz, Joanna Rutkowska, Upama Aich, Robert M Ross, Manuela S Santana, Joshua Wang, Nina Trubanová, Matthew J Page, Andrew Adrian Yu Pua, Yefeng Yang, Bawan Amin, April Robin Martinig, Adrian Barnett, Aswathi Surendran, Ju Zhang, David N Borg, Jafsia Elisee, James G Wrightson and Shinichi Nakagawa

Dominant activities of fear engram cells in the dorsal dentate gyrus underlie fear generalization in mice pp. 1-30

Kun Cui, Xuetao Qi, Zilong Liu, Weiqi Sun, Peijie Jiao, Chang Liu, Jifu Tong, Xiaoyan Sun, Haojie Sun, Su Fu, Jiaxin Wang, Yawen Zheng, Tianyu Liu, Shuang Cui, Fengyu Liu, Jian Mao, Jie Zheng, You Wan and Ming Yi

Volume 22, issue 6, 2024

How will better data (and better use of data) enable us to save the planet? pp. 1-14

Frank Hawkins

Analysis of animal-to-human translation shows that only 5% of animal-tested therapeutic interventions obtain regulatory approval for human applications pp. 1-19

Benjamin V Ineichen, Eva Furrer, Servan L Grüninger, Wolfgang E Zürrer and Malcolm R Macleod

Costs in conservation: Common costly mistakes and how to avoid them pp. 1-17

Vanessa M Adams

Now is the time for conservationists to stand up for social justice pp. 1-4

E J Milner-Gulland

Enabling usable science takes a community: Using our roles as funders to catalyze change pp. 1-4

Kayla J Ripple, Charlotte Hudson, Emily Knight, Jason P Landrum, Victoria Bell and Sarah L Close

Aligning data with decisions to address the biodiversity crisis pp. 1-3

Leah R Gerber and Gwenllian D Iacona

Humans can infer social preferences from decision speed alone pp. 1-27

Sophie Bavard, Erik Stuchlý, Arkady Konovalov and Sebastian Gluth

Morphometric brain organization across the human lifespan reveals increased dispersion linked to cognitive performance pp. 1-24

Jiao Li, Chao Zhang, Yao Meng, Siqi Yang, Jie Xia, Huafu Chen and Wei Liao

Volume 22, issue 5, 2024

Assessing the evolution of research topics in a biological field using plant science as an example pp. 1-27

Shin-Han Shiu and Melissa D Lehti-Shiu

Loss of Katnal2 leads to ependymal ciliary hyperfunction and autism-related phenotypes in mice pp. 1-33

Ryeonghwa Kang, Kyungdeok Kim, Yewon Jung, Sang-Han Choi, Chanhee Lee, Geun Ho Im, Miram Shin, Kwangmin Ryu, Subin Choi, Esther Yang, Wangyong Shin, Seungjoon Lee, Suho Lee, Zachary Papadopoulos, Ji Hoon Ahn, Gou Young Koh, Jonathan Kipnis, Hyojin Kang, Hyun Kim, Won-Ki Cho, Soochul Park, Seong-Gi Kim and Eunjoon Kim

Volume 22, issue 4, 2024

Modeling endosymbioses: Insights and hypotheses from theoretical approaches pp. 1-14

Lucas Santana Souza, Josephine Solowiej-Wedderburn, Adriano Bonforti and Eric Libby

Blik is an extensible 3D visualisation tool for the annotation and analysis of cryo-electron tomography data pp. 1-18

Lorenzo Gaifas, Moritz A Kirchner, Joanna Timmins and Irina Gutsche

A host-directed oxadiazole compound potentiates antituberculosis treatment via zinc poisoning in human macrophages and in a mouse model of infection pp. 1-32

Alexandra Maure, Emeline Lawarée, Francesco Fiorentino, Alexandre Pawlik, Saideep Gona, Alexandre Giraud-Gatineau, Matthew J G Eldridge, Anne Danckaert, David Hardy, Wafa Frigui, Camille Keck, Claude Gutierrez, Olivier Neyrolles, Nathalie Aulner, Antonello Mai, Mélanie Hamon, Luis B Barreiro, Priscille Brodin, Roland Brosch, Dante Rotili and Ludovic Tailleux

Neural populations within macaque early vestibular pathways are adapted to encode natural self-motion pp. 1-34

Mohammad Mohammadi, Jerome Carriot, Isabelle Mackrous, Kathleen E Cullen and Maurice J Chacron

A response to “Realism and robustness require increased sample size when studying both sexes” pp. 1-2

Benjamin Phillips, Timo N Haschler and Natasha A Karp

Realism and robustness require increased sample size when studying both sexes pp. 1-6

Szymon M Drobniak, Malgorzata Lagisz, Yefeng Yang and Shinichi Nakagawa

Mitofusin-mediated contacts between mitochondria and peroxisomes regulate mitochondrial fusion pp. 1-37

Cynthia Alsayyah, Manish K Singh, Maria Angeles Morcillo-Parra, Laetitia Cavellini, Nadav Shai, Christine Schmitt, Maya Schuldiner, Einat Zalckvar, Adeline Mallet, Naïma Belgareh-Touzé, Christophe Zimmer and Mickaël M Cohen

Volume 22, issue 3, 2024

GALDAR: A genetically encoded galactose sensor for visualizing sugar metabolism in vivo pp. 1-19

Uğurcan Sakizli, Tomomi Takano and Sa Kan Yoo

Specification of distinct cell types in a sensory-adhesive organ important for metamorphosis in tunicate larvae pp. 1-31

Christopher J Johnson, Florian Razy-Krajka, Fan Zeng, Katarzyna M Piekarz, Shweta Biliya, Ute Rothbächer and Alberto Stolfi

Volume 22, issue 2, 2024

The principle of uncertainty in biology: Will machine learning/artificial intelligence lead to the end of mechanistic studies? pp. 1-4

Victor de Lorenzo

The more, the healthier: Tree diversity reduces forest pests and pathogens pp. 1-3

Felicia Keesing and Richard S Ostfeld

Promoting research quality pp. 1-3

Ulrich Dirnagl and Nonia Pariente

Recommendations for accelerating open preprint peer review to improve the culture of science pp. 1-13

Michele Avissar-Whiting, Frédérique Belliard, Stefano M Bertozzi, Amy Brand, Katherine Brown, Géraldine Clément-Stoneham, Stephanie Dawson, Gautam Dey, Daniel Ecer, Scott C Edmunds, Ashley Farley, Tara D Fischer, Maryrose Franko, James S Fraser, Kathryn Funk, Clarisse Ganier, Melissa Harrison, Anna Hatch, Haley Hazlett, Samantha Hindle, Daniel W Hook, Phil Hurst, Sophien Kamoun, Robert Kiley, Michael M Lacy, Marcel LaFlamme, Rebecca Lawrence, Thomas Lemberger, Maria Leptin, Elliott Lumb, Catriona J MacCallum, Christopher Steven Marcum, Gabriele Marinello, Alex Mendonça, Sara Monaco, Kleber Neves, Damian Pattinson, Jessica K Polka, Iratxe Puebla, Martyn Rittman, Stephen J Royle, Daniela Saderi, Richard Sever, Kathleen Shearer, John E Spiro, Bodo Stern, Dario Taraborelli, Ron Vale, Claudia G Vasquez, Ludo Waltman, Fiona M Watt, Zara Y Weinberg and Mark Williams

Volume 22, issue 1, 2024

Bridging gaps in traditional research training with iBiology Courses pp. 1-5

Alexandra M Schnoes, Noah H Green, Thi A Nguyen, Ronald D Vale, Sarah S Goodwin and Shannon L Behrman

Finding the right power balance: Better study design and collaboration can reduce dependence on statistical power pp. 1-17

Shinichi Nakagawa, Malgorzata Lagisz, Yefeng Yang and Szymon M Drobniak

Thermal optima in the hypoxia tolerance of marine ectotherms: Physiological causes and biogeographic consequences pp. 1-17

Martin-Georg A Endress, Justin L Penn, Thomas H Boag, Benjamin P Burford, Erik A Sperling and Curtis A Deutsch

The parietal cortex has a causal role in ambiguity computations in humans pp. 1-30

Gabriela Valdebenito-Oyarzo, María Paz Martínez-Molina, Patricia Soto-Icaza, Francisco Zamorano, Alejandra Figueroa-Vargas, Josefina Larraín-Valenzuela, Ximena Stecher, César Salinas, Julien Bastin, Antoni Valero-Cabré, Rafael Polania and Pablo Billeke