New solutions for antibiotic discovery: Prioritizing microbial biosynthetic space using ecology and machine learning

Marnix H Medema and Gilles P van Wezel

PLOS Biology, 2025, vol. 23, issue 2, 1-3

Abstract: With the explosive increase in genome sequence data, perhaps the major challenge in natural-product-based drug discovery is the identification of gene clusters most likely to specify new chemistry and bioactivities. We discuss the challenges and state-of-the-art of antibiotic discovery based on ecological principles, genome mining and artificial intelligence.A major challenge in natural-product-based drug discovery is the identification of gene clusters most likely to specify new chemistry and bioactivities. This Perspective discusses the challenges and state of the art of antibiotic discovery.

Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pbio00:3003058

DOI: 10.1371/journal.pbio.3003058

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