A Dynamical Systems Hypothesis of Schizophrenia

Marco Loh, Edmund T Rolls and Gustavo Deco

PLOS Computational Biology, 2007, vol. 3, issue 11, 1-11

Abstract: We propose a top-down approach to the symptoms of schizophrenia based on a statistical dynamical framework. We show that a reduced depth in the basins of attraction of cortical attractor states destabilizes the activity at the network level due to the constant statistical fluctuations caused by the stochastic spiking of neurons. In integrate-and-fire network simulations, a decrease in the NMDA receptor conductances, which reduces the depth of the attractor basins, decreases the stability of short-term memory states and increases distractibility. The cognitive symptoms of schizophrenia such as distractibility, working memory deficits, or poor attention could be caused by this instability of attractor states in prefrontal cortical networks. Lower firing rates are also produced, and in the orbitofrontal and anterior cingulate cortex could account for the negative symptoms, including a reduction of emotions. Decreasing the GABA as well as the NMDA conductances produces not only switches between the attractor states, but also jumps from spontaneous activity into one of the attractors. We relate this to the positive symptoms of schizophrenia, including delusions, paranoia, and hallucinations, which may arise because the basins of attraction are shallow and there is instability in temporal lobe semantic memory networks, leading thoughts to move too freely round the attractor energy landscape. : One of the hallmarks of schizophrenia is the complexity and heterogeneity of the illness. We propose that part of the reason for the inconsistent symptoms may be a reduced signal-to-noise ratio and increased statistical fluctuations in different cortical brain networks. The novelty of the approach described here is that instead of basing our hypothesis purely on biological mechanisms, we develop a top-down approach based on the different types of symptoms and relate them to instabilities in attractor neural networks. Schizophrenia is characterized by cognitive, negative, and positive symptoms. We propose which characteristic effects in a dynamical system could cause these symptoms, and investigate our hypothesis in a computational model. We implement an integrate-and-fire network model and focus on the alterations of synaptic channels activated via NMDA and GABA receptors. We found that a decrease in the NMDA receptor conductance could contribute to both the cognitive and negative symptoms by reducing the neuronal firing rates and the stability of the attractor states. A reduction of both NMDA and GABA conductance causes an instability of the attractor states related to the positive symptoms. Overall, we provide a framework to discuss schizophrenia in a dynamical system framework.

Date: 2007
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pcbi00:0030228

DOI: 10.1371/journal.pcbi.0030228

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