 Uncovering the Dynamics of Cardiac Systems Using Stochastic Pacing and Frequency Domain AnalysesMathieu Lemay, Enno de Lange and Jan P Kucera PLOS Computational Biology, 2012, vol. 8, issue 3, 1-14 Abstract: Alternans of cardiac action potential duration (APD) is a well-known arrhythmogenic mechanism which results from dynamical instabilities. The propensity to alternans is classically investigated by examining APD restitution and by deriving APD restitution slopes as predictive markers. However, experiments have shown that such markers are not always accurate for the prediction of alternans. Using a mathematical ventricular cell model known to exhibit unstable dynamics of both membrane potential and Ca2+ cycling, we demonstrate that an accurate marker can be obtained by pacing at cycle lengths (CLs) varying randomly around a basic CL (BCL) and by evaluating the transfer function between the time series of CLs and APDs using an autoregressive-moving-average (ARMA) model. The first pole of this transfer function corresponds to the eigenvalue (λalt) of the dominant eigenmode of the cardiac system, which predicts that alternans occurs when λalt≤−1. For different BCLs, control values of λalt were obtained using eigenmode analysis and compared to the first pole of the transfer function estimated using ARMA model fitting in simulations of random pacing protocols. In all versions of the cell model, this pole provided an accurate estimation of λalt. Furthermore, during slow ramp decreases of BCL or simulated drug application, this approach predicted the onset of alternans by extrapolating the time course of the estimated λalt. In conclusion, stochastic pacing and ARMA model identification represents a novel approach to predict alternans without making any assumptions about its ionic mechanisms. It should therefore be applicable experimentally for any type of myocardial cell. Author Summary: Cardiac arrhythmias are frequent complications of heart disease and an important cause of morbidity and mortality. The rhythmic activity of the heart relies on the action potential, a bioelectrical signal characterized by complex dynamics involving ion currents and intracellular calcium cycling. When these dynamics become unstable, arrhythmogenic patterns can emerge. A typical example is the beat-to-beat alternation of action potential parameters, a phenomenon called alternans, which represents a well known mechanism precipitating severe arrhythmias. Alternans results from the interaction of action potentials during consecutive beats. Classically, this interaction is investigated by describing the dependence of action potential parameters on previous diastolic intervals and action potential durations. However, experiments have shown that quantitative markers derived in this way are only approximate or even inappropriate to predict alternans. Here, we devised a novel procedure for the reliable prediction of alternans, based on introducing small random variations of pacing intervals followed by signal processing in the frequency domain. Using a biophysical model of the cardiac cell, we demonstrate that our algorithm accurately predicts the onset of alternans during pacing at an accelerating rate or during the application of a drug. Our approach may thus open new perspectives for the clinical evaluation of arrhythmias. Date: 2012 Downloads: (external link) Related works: Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text Persistent link: https://EconPapers.repec.org/RePEc:plo:pcbi00:1002399 DOI: 10.1371/journal.pcbi.1002399 Access Statistics for this article More articles in PLOS Computational Biology from Public Library of Science |
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